[{"id":137,"uid":"NPDI-1wiJBw","name":"Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines.","napdiIdentifier":null,"overallSummary":"<p>Objectives.Marijuana is the most commonly used illicit drug during pregnancy. Due</p>\r\n<p>to high lipophilicity, cannabinoids can easily penetrate physiological barriers like</p>\r\n<p>the human placenta and jeopardize the developing fetus.We evaluated the impact</p>\r\n<p>of cannabidiol (CBD), a major non-psychoactive cannabinoid, on P-glycoprotein</p>\r\n<p>(P-gp) and Breast Cancer Resistance Protein (BCRP) expression, and P-gp function</p>\r\n<p>in a placental model, BeWo and Jar choriocarcinoma cell lines (using P-gp induced</p>\r\n<p>MCF7 cells (MCF7/P-gp) for comparison).</p>\r\n<p>Study design. Following the establishment of the basal expression of these transporters</p>\r\n<p>in the membrane fraction of all three cell lines, P-gp and BCRP protein</p>\r\n<p>and mRNA levels were determined following chronic (24–72 h) exposure to CBD,</p>\r\n<p>by Western Blot and qPCR. CBD impact on P-gp efflux function was examined</p>\r\n<p>by uptake of specific P-gp fluorescent substrates (calcein-AM, DiOC2(3) and rhodamine123(</p>\r\n<p>rh123)). Cyclosporine A (CsA) served as a positive control.</p>\r\n<p>Results. Chronic exposure to CBD resulted in significant changes in the protein and</p>\r\n<p>mRNA levels of both transporters. While P-gp was down-regulated, BCRP levels</p>\r\n<p>were up-regulated in the choriocarcinoma cell lines. CBD had a remarkably different</p>\r\n<p>influence on P-gp and BCRP expression in MCF7/P-gp cells, demonstrating that</p>\r\n<p>these are cell type specific effects. P-gp dependent efflux (of calcein, DiOC2(3) and</p>\r\n<p>rh123) was inhibited upon short-termexposure to CBD.</p>\r\n<p>Conclusions. Our study shows that CBD might alter P-gp and BCRP expression in</p>\r\n<p>the human placenta, and inhibit P-gp efflux function.We conclude that marijuana</p>\r\n<p>use during pregnancy may reduce placental protective functions and change its</p>\r\n<p>morphological and physiological characteristics.</p>","pubmedId":24058883,"embaseId":null,"croIdentifier":"Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev , Israel","croInformation":"Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev , Israel","dateStart":null,"dateEnd":null,"internalComment":"A published report from the literature. Data entered by CB and review by RB.","status":"published","compoundId":null,"naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","naturalProductSampleId":null,"studySourceTypeId":1,"naturalProduct":{"uid":"NP-0162af79-839e-40e2-af47-361c659061e9","binomial":"Cannabis sativa","name":"Cannabis","itis":null,"srs":"4495dd37-943e-434d-bf30-ea9172d543c8","source_id":"","conceptId":null},"compound":null,"studySourceType":{"id":1,"name":"Published report"},"experiments":[{"id":733,"uid":"NPDI-2LIXDQ","name":"Down regulation of P-gp transporter (protein) by Cannabidiol","overallEffect":-1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>N/A</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":"figure 3","internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":115,"cytochromeB5Id":null,"studyId":137,"experimentTypeId":6,"testSystemId":41,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":6,"name":"In Vitro Transporter Induction","isInVitro":true,"isTransporter":true,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00005002"},"objectCompound":null,"precipitantCompound":{"id":115,"name":"cannabidiol","unii":null,"inChIKey":"QHMBSVQNZZTUGM-ZWKOTPCHSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[{"id":11,"name":"P-gp (ABCB1)","conceptId":null,"experiment_transporter_xref":{"experiment":733,"transporte":11}}],"quantifiedMetabolites":[]},{"id":727,"uid":"NPDI-spUvqw","name":"Induction of BCRP transporter (mRNA) by Cannabidiol","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>N/A</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":"figure 5","internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":115,"cytochromeB5Id":null,"studyId":137,"experimentTypeId":6,"testSystemId":41,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":6,"name":"In Vitro Transporter Induction","isInVitro":true,"isTransporter":true,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00005002"},"objectCompound":null,"precipitantCompound":{"id":115,"name":"cannabidiol","unii":null,"inChIKey":"QHMBSVQNZZTUGM-ZWKOTPCHSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[{"id":1,"name":"BCRP (ABCG2)","conceptId":null,"experiment_transporter_xref":{"experiment":727,"transporte":1}}],"quantifiedMetabolites":[]},{"id":729,"uid":"NPDI-mbNW9A","name":"Induction of P-gp transporter (protein) by Cannabidiol","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>N/A</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":"figure 4","internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":115,"cytochromeB5Id":null,"studyId":137,"experimentTypeId":6,"testSystemId":42,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":6,"name":"In Vitro Transporter Induction","isInVitro":true,"isTransporter":true,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00005002"},"objectCompound":null,"precipitantCompound":{"id":115,"name":"cannabidiol","unii":null,"inChIKey":"QHMBSVQNZZTUGM-ZWKOTPCHSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[{"id":11,"name":"P-gp (ABCB1)","conceptId":null,"experiment_transporter_xref":{"experiment":729,"transporte":11}}],"quantifiedMetabolites":[]},{"id":730,"uid":"NPDI-PaO28A","name":"Non-induction of BCRP transporter  (protein) by Cannabiodiol","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>N/A</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":"figure 4","internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":115,"cytochromeB5Id":null,"studyId":137,"experimentTypeId":6,"testSystemId":42,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":6,"name":"In Vitro Transporter Induction","isInVitro":true,"isTransporter":true,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00005002"},"objectCompound":null,"precipitantCompound":{"id":115,"name":"cannabidiol","unii":null,"inChIKey":"QHMBSVQNZZTUGM-ZWKOTPCHSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[{"id":1,"name":"BCRP (ABCG2)","conceptId":null,"experiment_transporter_xref":{"experiment":730,"transporte":1}}],"quantifiedMetabolites":[]},{"id":737,"uid":"NPDI-Aasqdw","name":"Induction of BCRP transporter (protein) by Cannabidiol","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>N/A</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":"FIGURE 2","internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":115,"cytochromeB5Id":null,"studyId":137,"experimentTypeId":6,"testSystemId":40,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":6,"name":"In Vitro Transporter Induction","isInVitro":true,"isTransporter":true,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00005002"},"objectCompound":null,"precipitantCompound":{"id":115,"name":"cannabidiol","unii":null,"inChIKey":"QHMBSVQNZZTUGM-ZWKOTPCHSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[{"id":1,"name":"BCRP (ABCG2)","conceptId":null,"experiment_transporter_xref":{"experiment":737,"transporte":1}}],"quantifiedMetabolites":[]},{"id":728,"uid":"NPDI-E7xthw","name":"Down regulation of P-gp (mRNA) by Cannabidiol","overallEffect":-1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>N/A</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":"figure 5","internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":115,"cytochromeB5Id":null,"studyId":137,"experimentTypeId":6,"testSystemId":41,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":6,"name":"In Vitro Transporter Induction","isInVitro":true,"isTransporter":true,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00005002"},"objectCompound":null,"precipitantCompound":{"id":115,"name":"cannabidiol","unii":null,"inChIKey":"QHMBSVQNZZTUGM-ZWKOTPCHSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[{"id":11,"name":"P-gp (ABCB1)","conceptId":null,"experiment_transporter_xref":{"experiment":728,"transporte":11}}],"quantifiedMetabolites":[]},{"id":725,"uid":"NPDI-jHdxpA","name":"Induction (mRNA) of BCRP transporter with Cannabidiol","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>N/A</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":"figure 5","internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":115,"cytochromeB5Id":null,"studyId":137,"experimentTypeId":6,"testSystemId":40,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":6,"name":"In Vitro Transporter Induction","isInVitro":true,"isTransporter":true,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00005002"},"objectCompound":null,"precipitantCompound":{"id":115,"name":"cannabidiol","unii":null,"inChIKey":"QHMBSVQNZZTUGM-ZWKOTPCHSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[{"id":1,"name":"BCRP (ABCG2)","conceptId":null,"experiment_transporter_xref":{"experiment":725,"transporte":1}}],"quantifiedMetabolites":[]},{"id":732,"uid":"NPDI-Ix-KKg","name":"Induction of BCRP transporter (protein) by Cannabidiol","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>N/A</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":"FIGURE 3","internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":115,"cytochromeB5Id":null,"studyId":137,"experimentTypeId":6,"testSystemId":41,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":6,"name":"In Vitro Transporter Induction","isInVitro":true,"isTransporter":true,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00005002"},"objectCompound":null,"precipitantCompound":{"id":115,"name":"cannabidiol","unii":null,"inChIKey":"QHMBSVQNZZTUGM-ZWKOTPCHSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[{"id":1,"name":"BCRP (ABCG2)","conceptId":null,"experiment_transporter_xref":{"experiment":732,"transporte":1}}],"quantifiedMetabolites":[]},{"id":669,"uid":"NPDI-IoxesQ","name":"Inhibition of P-gp by Cannabidiol 10 µM","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>N/A</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":"<div><span lang=\"EN-US\">the accumulation measurement is intracellular accumulation as measured by fluorescence</span></div>","internalComment":null,"objectCompoundId":110,"objectMetaboliteCompoundId":null,"precipitantCompoundId":115,"cytochromeB5Id":null,"studyId":137,"experimentTypeId":5,"testSystemId":40,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":5,"name":"In Vitro Transporter Inhibition","isInVitro":true,"isTransporter":true,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000060"},"objectCompound":{"id":110,"name":"calcein-am","unii":null,"inChIKey":"XKFSBWQWNMZWFA-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"precipitantCompound":{"id":115,"name":"cannabidiol","unii":null,"inChIKey":"QHMBSVQNZZTUGM-ZWKOTPCHSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[{"id":11,"name":"P-gp (ABCB1)","conceptId":null,"experiment_transporter_xref":{"experiment":669,"transporte":11}}],"quantifiedMetabolites":[]},{"id":670,"uid":"NPDI-mLsAbQ","name":"Inhibition of P-gp by Cannabidiol 25 µM","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>N/A</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":"<div><span lang=\"EN-US\">the accumulation measurement is intracellular accumulation as measured by fluorescence</span></div>","internalComment":null,"objectCompoundId":95,"objectMetaboliteCompoundId":null,"precipitantCompoundId":115,"cytochromeB5Id":null,"studyId":137,"experimentTypeId":5,"testSystemId":42,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":5,"name":"In Vitro Transporter Inhibition","isInVitro":true,"isTransporter":true,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000060"},"objectCompound":{"id":95,"name":"rhodamine 123","unii":null,"inChIKey":"MYFATKRONKHHQL-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"precipitantCompound":{"id":115,"name":"cannabidiol","unii":null,"inChIKey":"QHMBSVQNZZTUGM-ZWKOTPCHSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[{"id":11,"name":"P-gp (ABCB1)","conceptId":null,"experiment_transporter_xref":{"experiment":670,"transporte":11}}],"quantifiedMetabolites":[]},{"id":735,"uid":"NPDI-DZj9Zg","name":"Down regulation of P-gp transporter (protein) by Cannabidiol","overallEffect":-1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>N/A</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":115,"cytochromeB5Id":null,"studyId":137,"experimentTypeId":6,"testSystemId":40,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":6,"name":"In Vitro Transporter Induction","isInVitro":true,"isTransporter":true,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00005002"},"objectCompound":null,"precipitantCompound":{"id":115,"name":"cannabidiol","unii":null,"inChIKey":"QHMBSVQNZZTUGM-ZWKOTPCHSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[{"id":11,"name":"P-gp (ABCB1)","conceptId":null,"experiment_transporter_xref":{"experiment":735,"transporte":11}}],"quantifiedMetabolites":[]},{"id":734,"uid":"NPDI-29ER6A","name":"Down regulation of P-gp transporter (protein) by Cannabidiol","overallEffect":-1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>N/A</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":"figure 2","internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":115,"cytochromeB5Id":null,"studyId":137,"experimentTypeId":6,"testSystemId":40,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":6,"name":"In Vitro Transporter Induction","isInVitro":true,"isTransporter":true,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00005002"},"objectCompound":null,"precipitantCompound":{"id":115,"name":"cannabidiol","unii":null,"inChIKey":"QHMBSVQNZZTUGM-ZWKOTPCHSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[{"id":11,"name":"P-gp (ABCB1)","conceptId":null,"experiment_transporter_xref":{"experiment":734,"transporte":11}}],"quantifiedMetabolites":[]},{"id":671,"uid":"NPDI-cqaAMA","name":"Inhibition of P-gp by Cannabidiol 10µM","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>N/A</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":"<div><span lang=\"EN-US\">the accumulation measurement is intracellular accumulation as measured by fluorescence</span></div>","internalComment":null,"objectCompoundId":213,"objectMetaboliteCompoundId":null,"precipitantCompoundId":115,"cytochromeB5Id":null,"studyId":137,"experimentTypeId":5,"testSystemId":40,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":5,"name":"In Vitro Transporter Inhibition","isInVitro":true,"isTransporter":true,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000060"},"objectCompound":{"id":213,"name":"3,3′-diethyloxacarbocyanine iodide","unii":null,"inChIKey":"FIZZUEJIOKEFFZ-UHFFFAOYSA-M","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"precipitantCompound":{"id":115,"name":"cannabidiol","unii":null,"inChIKey":"QHMBSVQNZZTUGM-ZWKOTPCHSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[{"id":11,"name":"P-gp (ABCB1)","conceptId":null,"experiment_transporter_xref":{"experiment":671,"transporte":11}}],"quantifiedMetabolites":[]},{"id":668,"uid":"NPDI-oZGcUg","name":"Inhibition of P-gp by Cannabidiol 25 µM","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>N/A</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":"<div><span lang=\"EN-US\">the accumulation measurement is intracellular accumulation as measured by fluorescence</span></div>","internalComment":null,"objectCompoundId":110,"objectMetaboliteCompoundId":null,"precipitantCompoundId":115,"cytochromeB5Id":null,"studyId":137,"experimentTypeId":5,"testSystemId":40,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":5,"name":"In Vitro Transporter Inhibition","isInVitro":true,"isTransporter":true,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000060"},"objectCompound":{"id":110,"name":"calcein-am","unii":null,"inChIKey":"XKFSBWQWNMZWFA-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"precipitantCompound":{"id":115,"name":"cannabidiol","unii":null,"inChIKey":"QHMBSVQNZZTUGM-ZWKOTPCHSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[{"id":11,"name":"P-gp (ABCB1)","conceptId":null,"experiment_transporter_xref":{"experiment":668,"transporte":11}}],"quantifiedMetabolites":[]},{"id":731,"uid":"NPDI-olqNRw","name":"Induction of BCRP transporter (protein) by Cannabidiol","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>N/A</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":"figure 3","internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":115,"cytochromeB5Id":null,"studyId":137,"experimentTypeId":6,"testSystemId":41,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":6,"name":"In Vitro Transporter Induction","isInVitro":true,"isTransporter":true,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00005002"},"objectCompound":null,"precipitantCompound":{"id":115,"name":"cannabidiol","unii":null,"inChIKey":"QHMBSVQNZZTUGM-ZWKOTPCHSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[{"id":1,"name":"BCRP (ABCG2)","conceptId":null,"experiment_transporter_xref":{"experiment":731,"transporte":1}}],"quantifiedMetabolites":[]}]}]