[{"id":57,"uid":"NPDI-2mUT0A","name":"Testing Green Tea as a Precipitant of Natural Product-Drug Interactions Using Raloxifene as the Object Drug","napdiIdentifier":null,"overallSummary":"Green tea administration resulted in decreased exposure to raloxifene and its two glucuronide metabolites.","pubmedId":null,"embaseId":null,"croIdentifier":"DPS-WSU-003","croInformation":"Washington State University","dateStart":null,"dateEnd":null,"internalComment":null,"status":"published","compoundId":null,"naturalProductUid":"NP-028bf4b2-0bc6-458f-b86f-6930ce40efc6","naturalProductSampleId":"NPS-G8hk_A","studySourceTypeId":3,"naturalProduct":{"uid":"NP-028bf4b2-0bc6-458f-b86f-6930ce40efc6","binomial":"Camellia sinensis","name":"Green tea","itis":null,"srs":"e9698137-24da-46f8-a70e-43e27691491f","source_id":"","conceptId":null},"compound":null,"studySourceType":{"id":3,"name":"Unpublished data submitted through a NaPDI form"},"experiments":[{"id":270,"uid":"NPDI-ukqA9Q","name":"Chronic Phase","overallEffect":-1,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":"<ul>\r\n<li>A pharmacokinetic interaction was observed between a well-characterized green tea and the intestinal UGT substrate raloxifene, as reflected by the geometric mean raloxifene AUC<sub>0-96h </sub>and C<sub>max</sub> decreasing to below the pre-defined no effect range (0.75-1.33).</li>\r\n<li>The unaltered raloxifene and glucuronide terminal half-lives, combined with unaltered ratios of glucuronide-to-raloxifene AUC<sub>0-96h</sub>, in the presence of green tea, suggested inhibition of intestinal UGT activity was not responsible for the observed interaction, different from the IVIVE prediction.</li>\r\n<li>The greater decrease in raloxifene geometric mean C<sub>max</sub> relative to AUC<sub>0-96h</sub> further suggested that green tea alters primarily processes in the intestine, which could include permeability, transport and/or physicochemical processes involved in raloxifene absorption.</li>\r\n<li>Note: all means are geometric and ratios are geometric mean ratios</li>\r\n<li> </li>\r\n</ul>","internalComment":null,"objectCompoundId":75,"objectMetaboliteCompoundId":null,"precipitantCompoundId":35,"cytochromeB5Id":null,"studyId":57,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo Interaction","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000071"},"objectCompound":{"id":75,"name":"raloxifene","unii":null,"inChIKey":"GZUITABIAKMVPG-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":1513103,"enantiomerOfId":null},"precipitantCompound":{"id":35,"name":"green tea leaf","unii":"W2ZU1RY8B0","inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[],"quantifiedMetabolites":[]},{"id":268,"uid":"NPDI-Y9AiTw","name":"Acute Phase","overallEffect":-1,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":"<ul>\r\n<li>A pharmacokinetic interaction was observed between a well-characterized green tea and the intestinal UGT substrate raloxifene, as reflected by the geometric mean raloxifene AUC<sub>0-96h </sub>and C<sub>max</sub> decreasing to below the pre-defined no effect range (0.75-1.33).</li>\r\n<li>The unaltered raloxifene and glucuronide terminal half-lives, combined with unaltered ratios of glucuronide-to-raloxifene AUC<sub>0-96h</sub>, in the presence of green tea, suggested inhibition of intestinal UGT activity was not responsible for the observed interaction, different from the IVIVE prediction.</li>\r\n<li>The greater decrease in raloxifene geometric mean C<sub>max</sub> relative to AUC<sub>0-96h</sub> further suggested that green tea alters primarily processes in the intestine, which could include permeability, transport and/or physicochemical processes involved in raloxifene absorption.</li>\r\n<li>Note: all means are geometric and ratios are geometric mean ratios</li>\r\n</ul>","internalComment":null,"objectCompoundId":75,"objectMetaboliteCompoundId":null,"precipitantCompoundId":35,"cytochromeB5Id":null,"studyId":57,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo Interaction","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000071"},"objectCompound":{"id":75,"name":"raloxifene","unii":null,"inChIKey":"GZUITABIAKMVPG-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":1513103,"enantiomerOfId":null},"precipitantCompound":{"id":35,"name":"green tea leaf","unii":"W2ZU1RY8B0","inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[],"quantifiedMetabolites":[]}]}]