Experiment #NPDI-5_pf-w CSV JSON

In Vitro Enzyme Induction Experiment

Induction was detected.  Cutoff used — Not specified

mitragynine

  • CYP3A4 4306811

Cell system HepG2 cell line

(Figure 2)
The expression of CYP3A4 was only slightly induced by mitragynine at all concentrations tested. Although this induction was statistically significant within the range of 1–5 uM of mitragynine, the induction relative to dexamethasone was generally less than 20% (18.1% and 17.5%, respectively)

Results

Sample Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

mRNA expression

0.1, 0.5, 1, 5, 10, 25 uM

48 hours

Control Experiment