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Data was entered by JY and reviewed by JS.","status":"published","compoundId":null,"naturalProductUid":"NP-028bf4b2-0bc6-458f-b86f-6930ce40efc6","naturalProductSampleId":null,"studySourceTypeId":1,"naturalProduct":{"uid":"NP-028bf4b2-0bc6-458f-b86f-6930ce40efc6","binomial":"Camellia sinensis","name":"Green tea","itis":null,"srs":"e9698137-24da-46f8-a70e-43e27691491f","source_id":"","conceptId":null},"compound":null,"studySourceType":{"id":1,"name":"Published report"},"experiments":[{"id":30,"uid":"NPDI-xsuAIg","name":null,"overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":null,"experimentalConditionsComment":"Total voided urine was collected for 8 h after probe drug administration.<br />Eligible subjects underwent a 4-week washout period, in which they were required to refrain from tea or its related products and herbal/botanical supplement, and to minimize the consumption of cruciferous vegetables. Subjects were required to abstain from caffeine-containing products and food items that have been reported to affect drug-metabolizing enzymes (e.g., grapefruit juice, cruciferous vegetables, and food cooked over charcoal), and over-the-counter medications beginning 72 h before and until 8 h after the probe drug administration. Study subjects were instructed to fast overnight for 8 h before and until 4 h after the administration of the probes.","resultsComment":"The unit presented in the article for AUC is ng/mL*min, which is currently not listed as an option. So it has been converted to ng/mL*h by the data curator. The P value was 0.01 (no such selection, so selected &lt; 0.05). Analysis from 41 subjects is presented.","internalComment":null,"objectCompoundId":59,"objectMetaboliteCompoundId":null,"precipitantCompoundId":35,"cytochromeB5Id":null,"studyId":14,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo Interaction","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000071"},"objectCompound":{"id":59,"name":"buspirone","unii":null,"inChIKey":"QWCRAEMEVRGPNT-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"precipitantCompound":{"id":35,"name":"green tea leaf","unii":"W2ZU1RY8B0","inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[{"id":13,"name":"CYP3A4","conceptId":4306811,"experiment_enzyme_xref":{"enzymeId":13,"experimentId":30}}],"transporters":[],"quantifiedMetabolites":[]},{"id":31,"uid":"NPDI-4v_54A","name":null,"overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":null,"experimentalConditionsComment":"Total voided urine was collected for 8 h after probe drug administration.<br />Eligible subjects underwent a 4-week washout period, in which they were required to refrain from tea or its related products and herbal/botanical supplement, and to minimize the consumption of cruciferous vegetables. Subjects were required to abstain from caffeine-containing products and food items that have been reported to affect drug-metabolizing enzymes (e.g., grapefruit juice, cruciferous vegetables, and food cooked over charcoal), and over-the-counter medications beginning 72 h before and until 8 h after the probe drug administration. Study subjects were instructed to fast overnight for 8 h before and until 4 h after the administration of the probes.","resultsComment":null,"internalComment":null,"objectCompoundId":7,"objectMetaboliteCompoundId":null,"precipitantCompoundId":35,"cytochromeB5Id":null,"studyId":14,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo Interaction","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000071"},"objectCompound":{"id":7,"name":"caffeine","unii":null,"inChIKey":"RYYVLZVUVIJVGH-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":1134439,"enantiomerOfId":null},"precipitantCompound":{"id":35,"name":"green tea leaf","unii":"W2ZU1RY8B0","inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[{"id":4,"name":"CYP1A2","conceptId":4312402,"experiment_enzyme_xref":{"enzymeId":4,"experimentId":31}}],"transporters":[],"quantifiedMetabolites":[]},{"id":32,"uid":"NPDI-FBHH1Q","name":null,"overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":null,"experimentalConditionsComment":"Total voided urine was collected for 8 h after probe drug administration.<br />Eligible subjects underwent a 4-week washout period, in which they were required to refrain from tea or its related products and herbal/botanical supplement, and to minimize the consumption of cruciferous vegetables. Subjects were required to abstain from caffeine-containing products and food items that have been reported to affect drug-metabolizing enzymes (e.g., grapefruit juice, cruciferous vegetables, and food cooked over charcoal), and over-the-counter medications beginning 72 h before and until 8 h after the probe drug administration. Study subjects were instructed to fast overnight for 8 h before and until 4 h after the administration of the probes.","resultsComment":null,"internalComment":null,"objectCompoundId":12,"objectMetaboliteCompoundId":null,"precipitantCompoundId":35,"cytochromeB5Id":null,"studyId":14,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo Interaction","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000071"},"objectCompound":{"id":12,"name":"dextromethorphan","unii":"7355X3ROTS","inChIKey":"MKXZASYAUGDDCJ-NJAFHUGGSA-N","publicDescription":null,"internalComment":null,"conceptId":1119510,"enantiomerOfId":null},"precipitantCompound":{"id":35,"name":"green tea leaf","unii":"W2ZU1RY8B0","inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[{"id":10,"name":"CYP2D6","conceptId":4173631,"experiment_enzyme_xref":{"enzymeId":10,"experimentId":32}}],"transporters":[],"quantifiedMetabolites":[]},{"id":34,"uid":"NPDI-H8eoWA","name":null,"overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":null,"experimentalConditionsComment":"Total voided urine was collected for 8 h after probe drug administration.<br />Eligible subjects underwent a 4-week washout period, in which they were required to refrain from tea or its related products and herbal/botanical supplement, and to minimize the consumption of cruciferous vegetables. Subjects were required to abstain from caffeine-containing products and food items that have been reported to affect drug-metabolizing enzymes (e.g., grapefruit juice, cruciferous vegetables, and food cooked over charcoal), and over-the-counter medications beginning 72 h before and until 8 h after the probe drug administration. Study subjects were instructed to fast overnight for 8 h before and until 4 h after the administration of the probes.","resultsComment":null,"internalComment":null,"objectCompoundId":61,"objectMetaboliteCompoundId":null,"precipitantCompoundId":35,"cytochromeB5Id":null,"studyId":14,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo Interaction","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000071"},"objectCompound":{"id":61,"name":"losartan","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"precipitantCompound":{"id":35,"name":"green tea leaf","unii":"W2ZU1RY8B0","inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[{"id":8,"name":"CYP2C9","conceptId":4309227,"experiment_enzyme_xref":{"enzymeId":8,"experimentId":34}}],"transporters":[],"quantifiedMetabolites":[]}]}]