[{"id":147,"uid":"NPDI-8SkM4A","name":"Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents","napdiIdentifier":null,"overallSummary":"The potential of licorice dietary supplements to interact with drug metabolism was evaluated by testing extracts of botanically identified licorice species <em>Glycyrrhiza glabra L.</em> and 14 isolated licorice compounds for inhibition of 9 cytochrome P450 enzymes using a UHPLC-MS/MS cocktail assay. <em>G. glabra </em>showed moderate inhibitory effects against CYP2B6, CYP2C8, CYP2C9, and CYP2C19, and weak inhibition against CYP3A4 (testosterone). The licorice compounds isoliquiritigenin, licoricidin, licochalcone A, 18β-glycyrrhetinic acid, and glycycoumarin inhibited one or more members of the CYP2C family of enzymes. Glycycoumarin and licochalcone A inhibited CYP1A2, but only glycycoumarin inhibited CYP2B6. Isoliquiritigenin, glabridin and licoricidin competitively inhibited CYP3A4. Licorice species commonly used in botanical dietary supplements have varying potential for drug-botanical interactions as inhibitors of cytochrome P450 isoforms. Each species of licorice displays a unique profile of constituents with potential for drug interactions.","pubmedId":28774812,"embaseId":null,"croIdentifier":"UIC","croInformation":"UIC","dateStart":"2017-03-22T00:00:00.000Z","dateEnd":"2017-07-30T00:00:00.000Z","internalComment":null,"status":"published","compoundId":null,"naturalProductUid":"NP-0241e87e-3900-4b1a-9dfa-70f7a06bbb15","naturalProductSampleId":null,"studySourceTypeId":1,"naturalProduct":{"uid":"NP-0241e87e-3900-4b1a-9dfa-70f7a06bbb15","binomial":"Glycyrrhiza glabra","name":"Licorice","itis":null,"srs":"b005d419-55e7-42a8-aacc-b110d6f9d37d","source_id":"","conceptId":null},"compound":null,"studySourceType":{"id":1,"name":"Published report"},"experiments":[{"id":708,"uid":"NPDI-DVoeXQ","name":"Inhibition of CYP2B6 by G. glabra Licorice extract","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>&gt; 100 &micro;g/mL</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":"<p>cocktail assay, IC50 values were determined according to the method of Li et al. (2015).</p>\r\n<p>Li, G., Huang, K., Nikolic, D., van Breemen, R.B., 2015. High-throughput cytochrome P450 cocktail inhibition assay for assessing drug-drug and drug-botanical interactions. Drug Metab. Dispos. 43, 1670–1678.</p>","resultsComment":null,"internalComment":null,"objectCompoundId":6,"objectMetaboliteCompoundId":24,"precipitantCompoundId":244,"cytochromeB5Id":null,"studyId":147,"experimentTypeId":1,"testSystemId":6,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":1,"name":"In Vitro Enzyme Inhibition","isInVitro":true,"isTransporter":false,"isEnzyme":true,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000058"},"objectCompound":{"id":6,"name":"bupropion","unii":"01ZG3TPX31","inChIKey":"SNPPWIUOZRMYNY-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":750982,"enantiomerOfId":null},"precipitantCompound":{"id":244,"name":"ethanolic extract of licorice g. glabra","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":{"id":24,"name":"hydroxybupropion","unii":null,"inChIKey":"AKOAEVOSDHIVFX-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":4037950,"enantiomerOfId":null},"enzymes":[{"id":6,"name":"CYP2B6","conceptId":4308333,"experiment_enzyme_xref":{"enzymeId":6,"experimentId":708}}],"transporters":[],"quantifiedMetabolites":[]},{"id":709,"uid":"NPDI-TGg2kA","name":"Inhibition of CYP2C8 by G. glabra Licorice extract","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>&gt; 100 &micro;g/mL</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":47,"objectMetaboliteCompoundId":48,"precipitantCompoundId":244,"cytochromeB5Id":null,"studyId":147,"experimentTypeId":1,"testSystemId":6,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":1,"name":"In Vitro Enzyme Inhibition","isInVitro":true,"isTransporter":false,"isEnzyme":true,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000058"},"objectCompound":{"id":47,"name":"amodiaquine","unii":null,"inChIKey":"OVCDSSHSILBFBN-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"precipitantCompound":{"id":244,"name":"ethanolic extract of licorice g. glabra","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":{"id":48,"name":"n-desethylamodiaquine","unii":null,"inChIKey":"VRXFDHAGFYWGHT-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"enzymes":[{"id":7,"name":"CYP2C8","conceptId":4306333,"experiment_enzyme_xref":{"enzymeId":7,"experimentId":709}}],"transporters":[],"quantifiedMetabolites":[]},{"id":710,"uid":"NPDI-1ZgdSQ","name":"Inhibition of CYP2C9 by G. glabra Licorice extract","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>&gt; 100 &micro;g/mL</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":174,"objectMetaboliteCompoundId":175,"precipitantCompoundId":244,"cytochromeB5Id":null,"studyId":147,"experimentTypeId":1,"testSystemId":6,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":1,"name":"In Vitro Enzyme Inhibition","isInVitro":true,"isTransporter":false,"isEnzyme":true,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000058"},"objectCompound":{"id":174,"name":"tolbutamide","unii":null,"inChIKey":"JLRGJRBPOGGCBT-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"precipitantCompound":{"id":244,"name":"ethanolic extract of licorice g. glabra","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":{"id":175,"name":"hydroxymethyltolbutamide","unii":null,"inChIKey":"SJRHYONYKZIRPM-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"enzymes":[{"id":8,"name":"CYP2C9","conceptId":4309227,"experiment_enzyme_xref":{"enzymeId":8,"experimentId":710}}],"transporters":[],"quantifiedMetabolites":[]},{"id":711,"uid":"NPDI-DtSHuA","name":"Inhibition of CYP2C19 by G. glabra Licorice extract","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>&gt; 100 &micro;g/mL</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":25,"objectMetaboliteCompoundId":3,"precipitantCompoundId":244,"cytochromeB5Id":null,"studyId":147,"experimentTypeId":1,"testSystemId":6,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":1,"name":"In Vitro Enzyme Inhibition","isInVitro":true,"isTransporter":false,"isEnzyme":true,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000058"},"objectCompound":{"id":25,"name":"mephenytoin, (s)-","unii":"D9818430MW","inChIKey":"GMHKMTDVRCWUDX-LBPRGKRZSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"precipitantCompound":{"id":244,"name":"ethanolic extract of licorice g. glabra","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":{"id":3,"name":"4-hydroxymephenytoin, (s)-","unii":null,"inChIKey":"OQPLORUDZLXXPD-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"enzymes":[{"id":9,"name":"CYP2C19","conceptId":4311137,"experiment_enzyme_xref":{"enzymeId":9,"experimentId":711}}],"transporters":[],"quantifiedMetabolites":[]},{"id":712,"uid":"NPDI-itM3Yw","name":"Inhibition of CYP3A4 by G. glabra Licorice extract","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>&gt; 100 &micro;g/mL</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":164,"objectMetaboliteCompoundId":165,"precipitantCompoundId":244,"cytochromeB5Id":null,"studyId":147,"experimentTypeId":1,"testSystemId":6,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":1,"name":"In Vitro Enzyme Inhibition","isInVitro":true,"isTransporter":false,"isEnzyme":true,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000058"},"objectCompound":{"id":164,"name":"testosterone","unii":null,"inChIKey":"MUMGGOZAMZWBJJ-DYKIIFRCSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"precipitantCompound":{"id":244,"name":"ethanolic extract of licorice g. glabra","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":{"id":165,"name":"6beta-hydroxytestosterone","unii":null,"inChIKey":"XSEGWEUVSZRCBC-ZVBLRVHNSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"enzymes":[{"id":13,"name":"CYP3A4","conceptId":4306811,"experiment_enzyme_xref":{"enzymeId":13,"experimentId":712}}],"transporters":[],"quantifiedMetabolites":[]},{"id":713,"uid":"NPDI-7z5LQg","name":"Negligible inhibition of CYP3A4 by G. glabra Licorice extract","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>&gt; 100 &micro;g/mL</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":26,"objectMetaboliteCompoundId":1,"precipitantCompoundId":244,"cytochromeB5Id":null,"studyId":147,"experimentTypeId":1,"testSystemId":6,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":1,"name":"In Vitro Enzyme Inhibition","isInVitro":true,"isTransporter":false,"isEnzyme":true,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000058"},"objectCompound":{"id":26,"name":"midazolam","unii":"R60L0SM5BC","inChIKey":"DDLIGBOFAVUZHB-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":708298,"enantiomerOfId":null},"precipitantCompound":{"id":244,"name":"ethanolic extract of licorice g. glabra","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":{"id":1,"name":"1'-hydroxymidazolam","unii":null,"inChIKey":"QHSMEGADRFZVNE-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"enzymes":[{"id":13,"name":"CYP3A4","conceptId":4306811,"experiment_enzyme_xref":{"enzymeId":13,"experimentId":713}}],"transporters":[],"quantifiedMetabolites":[]},{"id":714,"uid":"NPDI-YywAOQ","name":"Inhibition of CYP1A2 by G. glabra Licorice extract","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>&gt;100 &micro;g/ml</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":28,"objectMetaboliteCompoundId":5,"precipitantCompoundId":244,"cytochromeB5Id":null,"studyId":147,"experimentTypeId":1,"testSystemId":6,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":1,"name":"In Vitro Enzyme Inhibition","isInVitro":true,"isTransporter":false,"isEnzyme":true,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000058"},"objectCompound":{"id":28,"name":"phenacetin","unii":null,"inChIKey":"CPJSUEIXXCENMM-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":19033710,"enantiomerOfId":null},"precipitantCompound":{"id":244,"name":"ethanolic extract of licorice g. glabra","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":{"id":5,"name":"acetaminophen","unii":null,"inChIKey":"RZVAJINKPMORJF-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":1125315,"enantiomerOfId":null},"enzymes":[{"id":4,"name":"CYP1A2","conceptId":4312402,"experiment_enzyme_xref":{"enzymeId":4,"experimentId":714}}],"transporters":[],"quantifiedMetabolites":[]},{"id":715,"uid":"NPDI-0hKwgw","name":"Negligible inhibition of CYP2A6 by G. glabra Licorice extract","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>&gt; 100 &micro;g/ml</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":11,"objectMetaboliteCompoundId":4,"precipitantCompoundId":244,"cytochromeB5Id":null,"studyId":147,"experimentTypeId":1,"testSystemId":6,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":1,"name":"In Vitro Enzyme Inhibition","isInVitro":true,"isTransporter":false,"isEnzyme":true,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000058"},"objectCompound":{"id":11,"name":"coumarin","unii":null,"inChIKey":"ZYGHJZDHTFUPRJ-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":19008106,"enantiomerOfId":null},"precipitantCompound":{"id":244,"name":"ethanolic extract of licorice g. glabra","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":{"id":4,"name":"7-hydroxycoumarin","unii":null,"inChIKey":"ORHBXUUXSCNDEV-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"enzymes":[{"id":5,"name":"CYP2A6","conceptId":4309826,"experiment_enzyme_xref":{"enzymeId":5,"experimentId":715}}],"transporters":[],"quantifiedMetabolites":[]},{"id":716,"uid":"NPDI-d_tXmg","name":"Negligible inhibition of CYP2D6 by G. glabra Licorice extract","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>&gt; 100 &micro;g/ml</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":12,"objectMetaboliteCompoundId":13,"precipitantCompoundId":244,"cytochromeB5Id":null,"studyId":147,"experimentTypeId":1,"testSystemId":6,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":1,"name":"In Vitro Enzyme Inhibition","isInVitro":true,"isTransporter":false,"isEnzyme":true,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000058"},"objectCompound":{"id":12,"name":"dextromethorphan","unii":"7355X3ROTS","inChIKey":"MKXZASYAUGDDCJ-NJAFHUGGSA-N","publicDescription":null,"internalComment":null,"conceptId":1119510,"enantiomerOfId":null},"precipitantCompound":{"id":244,"name":"ethanolic extract of licorice g. glabra","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":{"id":13,"name":"dextrorphan","unii":null,"inChIKey":"JAQUASYNZVUNQP-PVAVHDDUSA-N","publicDescription":null,"internalComment":null,"conceptId":4349487,"enantiomerOfId":null},"enzymes":[{"id":10,"name":"CYP2D6","conceptId":4173631,"experiment_enzyme_xref":{"enzymeId":10,"experimentId":716}}],"transporters":[],"quantifiedMetabolites":[]},{"id":717,"uid":"NPDI-QkbxIg","name":"Negligible inhibition of CYP2E1 by G. glabra Licorice extract","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>&gt; 100 &micro;g/ml</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":129,"objectMetaboliteCompoundId":245,"precipitantCompoundId":244,"cytochromeB5Id":null,"studyId":147,"experimentTypeId":1,"testSystemId":6,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":1,"name":"In Vitro Enzyme Inhibition","isInVitro":true,"isTransporter":false,"isEnzyme":true,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000058"},"objectCompound":{"id":129,"name":"chloroxazone","unii":null,"inChIKey":"TZFWDZFKRBELIQ-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"precipitantCompound":{"id":244,"name":"ethanolic extract of licorice g. glabra","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":{"id":245,"name":"6-hydroxychloroxazone","unii":null,"inChIKey":"AGLXDWOTVQZHIQ-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"enzymes":[{"id":11,"name":"CYP2E1","conceptId":4173608,"experiment_enzyme_xref":{"enzymeId":11,"experimentId":717}}],"transporters":[],"quantifiedMetabolites":[]},{"id":707,"uid":"NPDI-XhhVrA","name":"Chemical characterization of Licorice, Glycyrrhiza glabra L.","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":"<p>% weight compound/weight extract<br /><br />glycycoumarin, licochalcone a, licoricidin had quantities of 0 and were excluded from the results</p>","internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":null,"cytochromeB5Id":null,"studyId":147,"experimentTypeId":10,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":10,"name":"Characterization of Material","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00005004"},"objectCompound":null,"precipitantCompound":null,"objectMetaboliteCompound":null,"enzymes":[],"transporters":[],"quantifiedMetabolites":[{"id":231,"name":"liquiritin apioside","unii":null,"inChIKey":"FTVKHUHJWDMWIR-DWMQJYMWSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null,"experiment_quantified_metabol":707},{"id":232,"name":"isoliquiritin apioside","unii":null,"inChIKey":"VMMVZVPAYFZNBM-KVFWHIKKSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null,"experiment_quantified_metabol":707},{"id":241,"name":"p-hydroxy-benzylmalonic acid (hbma)","unii":null,"inChIKey":"JXJNPXPDKYRHJT-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null,"experiment_quantified_metabol":707},{"id":239,"name":"glycyrrhetinic acid","unii":null,"inChIKey":"MPDGHEJMBKOTSU-PMTKVOBESA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null,"experiment_quantified_metabol":707},{"id":237,"name":"glabridin","unii":null,"inChIKey":"LBQIJVLKGVZRIW-ZDUSSCGKSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null,"experiment_quantified_metabol":707},{"id":236,"name":"glycyrrhizin","unii":null,"inChIKey":"LPLVUJXQOOQHMX-QWBHMCJMSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null,"experiment_quantified_metabol":707},{"id":235,"name":"isoliquiritigenin","unii":null,"inChIKey":"DXDRHHKMWQZJHT-FPYGCLRLSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null,"experiment_quantified_metabol":707},{"id":234,"name":"liquiritigenin","unii":null,"inChIKey":"FURUXTVZLHCCNA-AWEZNQCLSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null,"experiment_quantified_metabol":707},{"id":233,"name":"licuraside","unii":null,"inChIKey":"VMMVZVPAYFZNBM-FPYGCLRLSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null,"experiment_quantified_metabol":707},{"id":230,"name":"isoliquiritin","unii":null,"inChIKey":"YNWXJFQOCHMPCK-LXGDFETPSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null,"experiment_quantified_metabol":707},{"id":229,"name":"liquiritin","unii":null,"inChIKey":"DEMKZLAVQYISIA-ZRWXNEIDSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null,"experiment_quantified_metabol":707}]}]}]