[{"id":65,"uid":"NPDI-8lgFiA","name":"Interaction between Marihuana and Ethanol: Effects on Psychomotor Performance","napdiIdentifier":"PMID: 2837105","overallSummary":"This is a report of the results of a placebo-controlled study in which the effects of the interaction between ethanol and marihuana on drug plasmaconcentrations, subjectiveratingsof intoxication, heart rate acceleration, and psychomotor performance were investigated. Six healthy, male, paid volunteers, moderate users of ethanol and marihuana, participated in th estudy. Ethanol(0.42g/kg,0.85 g/kg, or placebo)was administered over a 30-min interval. Fifteen minutes later the subjects smoked, in their customary manner, NIDA cigarettes containing 2.4% or 0.0004% (placebo) δ-6-9-tetrahydrocannabinol (THC). Each subject was tested in a single-blind, latin-square crossover design with the following six conditions: placebo ethanol/ placebo marihuana; low dose ethanol/placebo marihuana; high dose ethanollplacebo marihuana; placebo ethanol/manhuana; low dose ethand/marihuana; and high dose ethand/marihuana. The variables measured in the study were: (a) subjective rating of ethanol and/or marihuana intoxication; (b) heart rate; (c) accuracy and latency of response in the Simulator Evaluationof Drug Impairment (SEDI) task; (d) blood ethanol concentration by gas chromatography; and (e) plasma concentration of THC by radioimmunoassay. The results indicate that the decrements due to ethanol in performance of skills necessary to drive an automobile were significantly enhanced by marihuana in an additive and perhaps synergistic manner. The administration of ethanol prior to marihuana smoking did not produce significant effects on the subjective rating of “high,” heart rate acceleration, or THC plasma concentration.","pubmedId":2837105,"embaseId":null,"croIdentifier":"Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill","croInformation":"Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill","dateStart":null,"dateEnd":null,"internalComment":null,"status":"published","compoundId":null,"naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","naturalProductSampleId":null,"studySourceTypeId":1,"naturalProduct":{"uid":"NP-0162af79-839e-40e2-af47-361c659061e9","binomial":"Cannabis sativa","name":"Cannabis","itis":null,"srs":"4495dd37-943e-434d-bf30-ea9172d543c8","source_id":"","conceptId":null},"compound":null,"studySourceType":{"id":1,"name":"Published report"},"experiments":[{"id":289,"uid":"NPDI-a65Zxg","name":"Mean THC Plasma Concentration with High Ethanol","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":"Figure 2","experimentalConditionsComment":"Blood samples drawn at described times after the beginning of ethanol administration","resultsComment":"Values converted from minutes. 
Original values:
\r\n\r\nFigure 2.","internalComment":null,"objectCompoundId":118,"objectMetaboliteCompoundId":null,"precipitantCompoundId":125,"cytochromeB5Id":null,"studyId":65,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo Interaction","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000071"},"objectCompound":{"id":118,"name":"delta-9-tetrahydrocannabinol","unii":null,"inChIKey":"CYQFCXCEBYINGO-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"precipitantCompound":{"id":125,"name":"ethanol","unii":null,"inChIKey":"LFQSCWFLJHTTHZ-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[],"quantifiedMetabolites":[]},{"id":290,"uid":"NPDI-ypo3GA","name":"Mean THC Plasma Concentration with High Ethanol","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":"Figure 2","experimentalConditionsComment":null,"resultsComment":"Values converted from minutes. 
Original values:
\r\n\r\nFigure 2","internalComment":null,"objectCompoundId":118,"objectMetaboliteCompoundId":null,"precipitantCompoundId":125,"cytochromeB5Id":null,"studyId":65,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo Interaction","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000071"},"objectCompound":{"id":118,"name":"delta-9-tetrahydrocannabinol","unii":null,"inChIKey":"CYQFCXCEBYINGO-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"precipitantCompound":{"id":125,"name":"ethanol","unii":null,"inChIKey":"LFQSCWFLJHTTHZ-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[],"quantifiedMetabolites":[]},{"id":291,"uid":"NPDI-PwGUoQ","name":"Mean THC Concentration with Placebo","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":"Figure 2
Placebo is orange juice sprayed with 100-proof vodka","experimentalConditionsComment":null,"resultsComment":"Values converted from minutes.
Original values:
\r\n\r\nFigure 2.","internalComment":null,"objectCompoundId":118,"objectMetaboliteCompoundId":null,"precipitantCompoundId":117,"cytochromeB5Id":null,"studyId":65,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo Interaction","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000071"},"objectCompound":{"id":118,"name":"delta-9-tetrahydrocannabinol","unii":null,"inChIKey":"CYQFCXCEBYINGO-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"precipitantCompound":{"id":117,"name":"placebo","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[],"quantifiedMetabolites":[]}]}]