[{"id":792,"uid":"NPDI-BacmiQ","name":"Guggul oleo-gum resin extract Nuclear Receptor Induction study - Ole Miss","napdiIdentifier":null,"overallSummary":"<span class=\"TextRun SCXW78147245 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW78147245 BCX0\">PXR is a key regulator for the expression of CYP 3A4 which is involved in the metabolism of majority of clinical drugs. Induction of PXR has been known to be associated with pharmacokinetic drug interactions.</span></span><span class=\"EOP SCXW78147245 BCX0\" data-ccp-props=\"{}\"> <br />AhR<span class=\"TextRun SCXW124633604 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW124633604 BCX0\"> is involved in regulation of the expression of certain CYP isoforms. Phytochemicals could be the </span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW124633604 BCX0\">AhR</span><span class=\"NormalTextRun SCXW124633604 BCX0\"> agonists and induction of </span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW124633604 BCX0\">AhR</span><span class=\"NormalTextRun SCXW124633604 BCX0\"> could play a role in herb-drug </span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW124633604 BCX0\">interation</span><span class=\"NormalTextRun SCXW124633604 BCX0\">.</span></span><span class=\"EOP SCXW124633604 BCX0\" data-ccp-props=\"{}\"> </span></span>","pubmedId":36017806,"embaseId":null,"croIdentifier":"NCNPR-PXR-AHR-guggul-1","croInformation":"Natural Center for Natural Products Research","dateStart":null,"dateEnd":null,"internalComment":null,"status":"published","compoundId":null,"naturalProductUid":"NP-97718afe-4e5a-4e49-ae3e-537c4a4794f6","naturalProductSampleId":null,"studySourceTypeId":1,"naturalProduct":{"uid":"NP-97718afe-4e5a-4e49-ae3e-537c4a4794f6","binomial":"Commiphora mukul","name":"Guggul","itis":null,"srs":"d9412417-1759-4dff-b538-21b9de52e0b5","source_id":"","conceptId":null},"compound":null,"studySourceType":{"id":1,"name":"Published report"},"experiments":[{"id":1126,"uid":"NPDI-MiC5sg","name":"Guggul - In Vitro Nuclear Receptor Induction PXR Experiment - 1","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p><span class=\"TextRun SCXW120251742 BCX0\" lang=\"EN-US\" style=\"margin: 0px; padding: 0px; user-select: text; -webkit-user-drag: none; -webkit-tap-highlight-color: transparent; font-variant-ligatures: none !important; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 11pt; line-height: 19.55px; font-family: Calibri, Calibri_EmbeddedFont, Calibri_MSFontService, sans-serif;\" data-contrast=\"auto\">An activation of 2-folds or higher.</span><span class=\"EOP SCXW120251742 BCX0\" style=\"margin: 0px; padding: 0px; user-select: text; -webkit-user-drag: none; -webkit-tap-highlight-color: transparent; color: #000000; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 11pt; line-height: 19.55px; font-family: Calibri, Calibri_EmbeddedFont, Calibri_MSFontService, sans-serif;\" data-ccp-props=\"{\">&nbsp;</span></p>","croIdentifier":"ole-miss-guggul-pxr-induction-1","comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":314,"cytochromeB5Id":null,"studyId":792,"experimentTypeId":13,"testSystemId":45,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":13,"name":"In Vitro Nuclear Receptor Induction","isInVitro":true,"isTransporter":false,"isEnzyme":true,"purl":"http://purl.obolibrary.org/obo/DIDEO_999999991"},"objectCompound":null,"precipitantCompound":{"id":314,"name":"guggul extract","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[{"id":39,"name":"Pregnane X receptor (PXR)","conceptId":null,"experiment_enzyme_xref":{"enzymeId":39,"experimentId":1126}}],"transporters":[],"quantifiedMetabolites":[]},{"id":1127,"uid":"NPDI-58ZuPA","name":"Guggul - In Vitro Nuclear Receptor Induction PXR Experiment - 2","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p><span class=\"TextRun SCXW167622856 BCX0\" lang=\"EN-US\" style=\"margin: 0px; padding: 0px; user-select: text; -webkit-user-drag: none; -webkit-tap-highlight-color: transparent; font-variant-ligatures: none !important; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 11pt; line-height: 19.55px; font-family: Calibri, Calibri_EmbeddedFont, Calibri_MSFontService, sans-serif;\" data-contrast=\"auto\">An activation of 2-folds or higher.</span><span class=\"EOP SCXW167622856 BCX0\" style=\"margin: 0px; padding: 0px; user-select: text; -webkit-user-drag: none; -webkit-tap-highlight-color: transparent; color: #000000; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 11pt; line-height: 19.55px; font-family: Calibri, Calibri_EmbeddedFont, Calibri_MSFontService, sans-serif;\" data-ccp-props=\"{\">&nbsp;</span></p>","croIdentifier":"ole-miss-guggul-pxr-induction-2","comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":314,"cytochromeB5Id":null,"studyId":792,"experimentTypeId":13,"testSystemId":45,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":13,"name":"In Vitro Nuclear Receptor Induction","isInVitro":true,"isTransporter":false,"isEnzyme":true,"purl":"http://purl.obolibrary.org/obo/DIDEO_999999991"},"objectCompound":null,"precipitantCompound":{"id":314,"name":"guggul extract","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[{"id":39,"name":"Pregnane X receptor (PXR)","conceptId":null,"experiment_enzyme_xref":{"enzymeId":39,"experimentId":1127}}],"transporters":[],"quantifiedMetabolites":[]},{"id":1128,"uid":"NPDI-qknqQg","name":"Guggul - In Vitro Nuclear Receptor Induction PXR Experiment - 3","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p><span class=\"TextRun SCXW103457652 BCX0\" lang=\"EN-US\" style=\"margin: 0px; padding: 0px; user-select: text; -webkit-user-drag: none; -webkit-tap-highlight-color: transparent; font-variant-ligatures: none !important; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 11pt; line-height: 19.55px; font-family: Calibri, Calibri_EmbeddedFont, Calibri_MSFontService, sans-serif;\" data-contrast=\"auto\">An activation of 2-folds or higher.</span><span class=\"EOP SCXW103457652 BCX0\" style=\"margin: 0px; padding: 0px; user-select: text; -webkit-user-drag: none; -webkit-tap-highlight-color: transparent; color: #000000; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 11pt; line-height: 19.55px; font-family: Calibri, Calibri_EmbeddedFont, Calibri_MSFontService, sans-serif;\" data-ccp-props=\"{\">&nbsp;</span></p>","croIdentifier":"ole-miss-guggul-pxr-induction-3","comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":314,"cytochromeB5Id":null,"studyId":792,"experimentTypeId":13,"testSystemId":45,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":13,"name":"In Vitro Nuclear Receptor Induction","isInVitro":true,"isTransporter":false,"isEnzyme":true,"purl":"http://purl.obolibrary.org/obo/DIDEO_999999991"},"objectCompound":null,"precipitantCompound":{"id":314,"name":"guggul extract","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[{"id":39,"name":"Pregnane X receptor (PXR)","conceptId":null,"experiment_enzyme_xref":{"enzymeId":39,"experimentId":1128}}],"transporters":[],"quantifiedMetabolites":[]},{"id":1129,"uid":"NPDI-nxqK6A","name":"Guggul - In Vitro Nuclear Receptor Induction AHR Experiment - 1","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p><span class=\"TextRun SCXW111660003 BCX0\" lang=\"EN-US\" style=\"margin: 0px; padding: 0px; user-select: text; -webkit-user-drag: none; -webkit-tap-highlight-color: transparent; font-variant-ligatures: none !important; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 11pt; line-height: 19.55px; font-family: Calibri, Calibri_EmbeddedFont, Calibri_MSFontService, sans-serif;\" data-contrast=\"auto\">An activation of 2-folds or higher.</span><span class=\"EOP SCXW111660003 BCX0\" style=\"margin: 0px; padding: 0px; user-select: text; -webkit-user-drag: none; -webkit-tap-highlight-color: transparent; color: #000000; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 11pt; line-height: 19.55px; font-family: Calibri, Calibri_EmbeddedFont, Calibri_MSFontService, sans-serif;\" data-ccp-props=\"{\">&nbsp;</span></p>","croIdentifier":"ole-miss-guggul-ahr-induction-1","comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":314,"cytochromeB5Id":null,"studyId":792,"experimentTypeId":13,"testSystemId":46,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":13,"name":"In Vitro Nuclear Receptor Induction","isInVitro":true,"isTransporter":false,"isEnzyme":true,"purl":"http://purl.obolibrary.org/obo/DIDEO_999999991"},"objectCompound":null,"precipitantCompound":{"id":314,"name":"guggul extract","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[{"id":40,"name":"Aryl hydrocarbon receptor (AHR)","conceptId":null,"experiment_enzyme_xref":{"enzymeId":40,"experimentId":1129}}],"transporters":[],"quantifiedMetabolites":[]},{"id":1130,"uid":"NPDI-xl99fQ","name":"Guggul - In Vitro Nuclear Receptor Induction AHR Experiment - 2","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p><span class=\"TextRun SCXW89566915 BCX0\" lang=\"EN-US\" style=\"margin: 0px; padding: 0px; user-select: text; -webkit-user-drag: none; -webkit-tap-highlight-color: transparent; font-variant-ligatures: none !important; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 11pt; line-height: 19.55px; font-family: Calibri, Calibri_EmbeddedFont, Calibri_MSFontService, sans-serif;\" data-contrast=\"auto\">An activation of 2-folds or higher.</span><span class=\"EOP SCXW89566915 BCX0\" style=\"margin: 0px; padding: 0px; user-select: text; -webkit-user-drag: none; -webkit-tap-highlight-color: transparent; color: #000000; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 11pt; line-height: 19.55px; font-family: Calibri, Calibri_EmbeddedFont, Calibri_MSFontService, sans-serif;\" data-ccp-props=\"{\">&nbsp;</span></p>","croIdentifier":"ole-miss-guggul-ahr-induction-2","comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":314,"cytochromeB5Id":null,"studyId":792,"experimentTypeId":13,"testSystemId":46,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":13,"name":"In Vitro Nuclear Receptor Induction","isInVitro":true,"isTransporter":false,"isEnzyme":true,"purl":"http://purl.obolibrary.org/obo/DIDEO_999999991"},"objectCompound":null,"precipitantCompound":{"id":314,"name":"guggul extract","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[{"id":40,"name":"Aryl hydrocarbon receptor (AHR)","conceptId":null,"experiment_enzyme_xref":{"enzymeId":40,"experimentId":1130}}],"transporters":[],"quantifiedMetabolites":[]},{"id":1131,"uid":"NPDI-iykw-w","name":"Guggul - In Vitro Nuclear Receptor Induction AHR Experiment - 3","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p><span class=\"TextRun SCXW100068670 BCX0\" lang=\"EN-US\" style=\"margin: 0px; padding: 0px; user-select: text; -webkit-user-drag: none; -webkit-tap-highlight-color: transparent; font-variant-ligatures: none !important; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 11pt; line-height: 19.55px; font-family: Calibri, Calibri_EmbeddedFont, Calibri_MSFontService, sans-serif;\" data-contrast=\"auto\">An activation of 2-folds or higher.</span><span class=\"EOP SCXW100068670 BCX0\" style=\"margin: 0px; padding: 0px; user-select: text; -webkit-user-drag: none; -webkit-tap-highlight-color: transparent; color: #000000; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 11pt; line-height: 19.55px; font-family: Calibri, Calibri_EmbeddedFont, Calibri_MSFontService, sans-serif;\" data-ccp-props=\"{\">&nbsp;</span></p>","croIdentifier":"ole-miss-guggul-ahr-induction-3","comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":314,"cytochromeB5Id":null,"studyId":792,"experimentTypeId":13,"testSystemId":46,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":13,"name":"In Vitro Nuclear Receptor Induction","isInVitro":true,"isTransporter":false,"isEnzyme":true,"purl":"http://purl.obolibrary.org/obo/DIDEO_999999991"},"objectCompound":null,"precipitantCompound":{"id":314,"name":"guggul extract","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[{"id":40,"name":"Aryl hydrocarbon receptor (AHR)","conceptId":null,"experiment_enzyme_xref":{"enzymeId":40,"experimentId":1131}}],"transporters":[],"quantifiedMetabolites":[]}]}]