[{"id":15,"uid":"NPDI-K89fCg","name":"Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E.","napdiIdentifier":"PMID:11205489","overallSummary":"Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E. There are a total of 8 experiments, 1 each for EGCG capsules at 4 dose levels, and 1 each for Polyphenon E capsules at 4 dose levels. <br /><br />The PK results for the EGCG compound is recorded for the four experiments that used EGCG capsules but not the 4 experiments using Polyphenon E capsules because the there were not significant differences at any of the dose levels. This is true for both unconjugated and total EGCG.<br /><br />The EGC and EC results were only available for the 4 Polyphenon E experiments and these are recorded.","pubmedId":11205489,"embaseId":null,"croIdentifier":"T4","croInformation":"Various academic, government, and commercial entities","dateStart":null,"dateEnd":null,"internalComment":"This is a study reported in the literature. The data was entered by RB and reviewed by JY (entries not completed yet).","status":"published","compoundId":null,"naturalProductUid":"NP-028bf4b2-0bc6-458f-b86f-6930ce40efc6","naturalProductSampleId":null,"studySourceTypeId":1,"naturalProduct":{"uid":"NP-028bf4b2-0bc6-458f-b86f-6930ce40efc6","binomial":"Camellia sinensis","name":"Green tea","itis":null,"srs":"e9698137-24da-46f8-a70e-43e27691491f","source_id":"","conceptId":null},"compound":null,"studySourceType":{"id":1,"name":"Published report"},"experiments":[{"id":120,"uid":"NPDI-UhMAjQ","name":"In vivo PK of tea polyphenols 400 mg EGCG capsules","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":"The authors report a CL/F value but they don't have or mention administration of any IV formulation to use for calculating oral bioavailability (assuming F = (AUC_{po}XDose_{iv})/(AUC_{iv}XDose_{po}). So, I think that the they are really just reporting Cl from Dose/AUC. A similar comment applies to volume of distribution. These two values have not been entered into the repository.","internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":null,"cytochromeB5Id":null,"studyId":15,"experimentTypeId":8,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":8,"name":"In Vivo Pharmacokinetics","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000075"},"objectCompound":null,"precipitantCompound":null,"objectMetaboliteCompound":null,"enzymes":[],"transporters":[],"quantifiedMetabolites":[]},{"id":125,"uid":"NPDI-MopEIQ","name":"In vivo PK of tea polyphenols 600 mg Polyphenon E capsules","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":null,"cytochromeB5Id":null,"studyId":15,"experimentTypeId":8,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":8,"name":"In Vivo Pharmacokinetics","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000075"},"objectCompound":null,"precipitantCompound":null,"objectMetaboliteCompound":null,"enzymes":[],"transporters":[],"quantifiedMetabolites":[]},{"id":123,"uid":"NPDI-EVjSRA","name":"In vivo PK of  tea polyphenols 200 mg Polyphenon E capsules","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":"All of these results are the sum of unchanged and conjugated forms reported in Table 3","internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":null,"cytochromeB5Id":null,"studyId":15,"experimentTypeId":8,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":8,"name":"In Vivo Pharmacokinetics","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000075"},"objectCompound":null,"precipitantCompound":null,"objectMetaboliteCompound":null,"enzymes":[],"transporters":[],"quantifiedMetabolites":[]},{"id":122,"uid":"NPDI-iisBhQ","name":"In vivo PK of tea polyphenols 800 mg EGCG capsules","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":"The authors report a CL/F value but they don't have or mention administration of any IV formulation to use for calculating oral bioavailability (assuming F = (AUC_{po}XDose_{iv})/(AUC_{iv}XDose_{po}). So, I think that the they are really just reporting Cl from Dose/AUC. A similar comment applies to volume of distribution. These two values have not been entered into the repository.","internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":null,"cytochromeB5Id":null,"studyId":15,"experimentTypeId":8,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":8,"name":"In Vivo Pharmacokinetics","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000075"},"objectCompound":null,"precipitantCompound":null,"objectMetaboliteCompound":null,"enzymes":[],"transporters":[],"quantifiedMetabolites":[]},{"id":126,"uid":"NPDI-IkNjmw","name":"In vivo PK of tea polyphenols 800 mg Polyphenon E capsules","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":null,"cytochromeB5Id":null,"studyId":15,"experimentTypeId":8,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":8,"name":"In Vivo Pharmacokinetics","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000075"},"objectCompound":null,"precipitantCompound":null,"objectMetaboliteCompound":null,"enzymes":[],"transporters":[],"quantifiedMetabolites":[]},{"id":124,"uid":"NPDI-_7AWMw","name":"In vivo PK of tea polyphenols 400 mg Polyphenon E capsules","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":null,"cytochromeB5Id":null,"studyId":15,"experimentTypeId":8,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":8,"name":"In Vivo Pharmacokinetics","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000075"},"objectCompound":null,"precipitantCompound":null,"objectMetaboliteCompound":null,"enzymes":[],"transporters":[],"quantifiedMetabolites":[]},{"id":121,"uid":"NPDI-aYDjxA","name":"In vivo PK of tea polyphenols 600 mg EGCG capsules","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":"The authors report a CL/F value but they don't have or mention administration of any IV formulation to use for calculating oral bioavailability (assuming F = (AUC_{po}XDose_{iv})/(AUC_{iv}XDose_{po}). So, I think that the they are really just reporting Cl from Dose/AUC. A similar comment applies to volume of distribution. These two values have not been entered into the repository.","internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":null,"cytochromeB5Id":null,"studyId":15,"experimentTypeId":8,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":8,"name":"In Vivo Pharmacokinetics","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000075"},"objectCompound":null,"precipitantCompound":null,"objectMetaboliteCompound":null,"enzymes":[],"transporters":[],"quantifiedMetabolites":[]},{"id":35,"uid":"NPDI-fXRM8w","name":"In vivo PK of  tea polyphenols 200 mg EGCG capsules","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":"The authors report a CL/F value but they don't have or mention administration of any IV formulation to use for calculating oral bioavailability (assuming F = (AUC_{po}XDose_{iv})/(AUC_{iv}XDose_{po}). So, I think that the they are really just reporting Cl from Dose/AUC. A similar comment applies to volume of distribution. These two values have not been entered into the repository.","internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":null,"cytochromeB5Id":null,"studyId":15,"experimentTypeId":8,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":8,"name":"In Vivo Pharmacokinetics","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000075"},"objectCompound":null,"precipitantCompound":null,"objectMetaboliteCompound":null,"enzymes":[],"transporters":[],"quantifiedMetabolites":[]}]}]