In Vitro Enzyme Induction Experiment
Induction was detected. Cutoff used — Not specified
- CYP1A2 4312402
Cell system HepG2 cell line
the protein expression of CYP1A2 showed an increased in relative values from 0.5uM onwards as compared to control. Concentration-dependent effects was only observed from 0.1 to 1.0 uM. The mean relative intensity at 1 and 10 lM showed an increase in value, which corresponded with the positive control (omepra- zole). The effect of mitragynine on the CYP1A2 protein expression was consistent with the effect observed on CYP1A2 mRNA expression, although the concentration-dependent effects were not as obvious.
|Sample||Compound measured||Measurement||Value||Study sequence||Additional information||N replicates|
0.1, 0.5, 1, 5, 10, 25 uM