Experiment #NPDI-LcX0tA CSV JSON

In Vitro Enzyme Induction Experiment

Induction was detected.  Cutoff used — Not specified


  • CYP3A4 4306811

Cell system HepG2 cell line


"Mitragynine appeared to moderately induce the enzymatic activity of CYP3A4. The increase was gradual and the changes in the enzymatic activity were minimal. The greatest increase in CYP3A4 enzymatic activity, approximately 43.0% relative to the positive control, was observed when cells were treated with mitragynine at 25 lM (Fig. 4b)."

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

Enzyme activity

Control Experiment