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The licorice species commonly used in botanical dietary supplements have varying potential for drug-botanical interactions as inhibitors of cytochrome P450 isoforms. Each species of licorice displays a unique profile of constituents with potential for drug interactions.</p>","pubmedId":28774812,"embaseId":null,"croIdentifier":"UIC","croInformation":"UIC","dateStart":"2017-03-22T00:00:00.000Z","dateEnd":"2017-07-30T00:00:00.000Z","internalComment":null,"status":"published","compoundId":null,"naturalProductUid":"NP-01b14067-1b74-4ddb-a95e-84cf2f220c46","naturalProductSampleId":null,"studySourceTypeId":1,"naturalProduct":{"uid":"NP-01b14067-1b74-4ddb-a95e-84cf2f220c46","binomial":"Glycyrrhiza uralensis","name":"Licorice","itis":null,"srs":"dc6f848b-18bb-4620-81b1-b2af39721bd9","source_id":"","conceptId":null},"compound":null,"studySourceType":{"id":1,"name":"Published report"},"experiments":[{"id":766,"uid":"NPDI-ST3yYQ","name":"Negligible inhibition of CYP2A6 by G. uralensis Licorice extract","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>&gt; 100 &micro;g/ml</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":11,"objectMetaboliteCompoundId":4,"precipitantCompoundId":254,"cytochromeB5Id":null,"studyId":155,"experimentTypeId":1,"testSystemId":6,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":1,"name":"In Vitro Enzyme Inhibition","isInVitro":true,"isTransporter":false,"isEnzyme":true,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000058"},"objectCompound":{"id":11,"name":"coumarin","unii":null,"inChIKey":"ZYGHJZDHTFUPRJ-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":19008106,"enantiomerOfId":null},"precipitantCompound":{"id":254,"name":"ethanolic extract of licorice g. uralensis","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":{"id":4,"name":"7-hydroxycoumarin","unii":null,"inChIKey":"ORHBXUUXSCNDEV-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"enzymes":[{"id":5,"name":"CYP2A6","conceptId":4309826,"experiment_enzyme_xref":{"enzymeId":5,"experimentId":766}}],"transporters":[],"quantifiedMetabolites":[]},{"id":767,"uid":"NPDI-DqqLBA","name":"Negligible inhibition of CYP1A2 by G. uralensis Licorice extract","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>&gt;100 &micro;g/ml</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":28,"objectMetaboliteCompoundId":5,"precipitantCompoundId":254,"cytochromeB5Id":null,"studyId":155,"experimentTypeId":1,"testSystemId":6,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":1,"name":"In Vitro Enzyme Inhibition","isInVitro":true,"isTransporter":false,"isEnzyme":true,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000058"},"objectCompound":{"id":28,"name":"phenacetin","unii":null,"inChIKey":"CPJSUEIXXCENMM-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":19033710,"enantiomerOfId":null},"precipitantCompound":{"id":254,"name":"ethanolic extract of licorice g. uralensis","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":{"id":5,"name":"acetaminophen","unii":null,"inChIKey":"RZVAJINKPMORJF-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":1125315,"enantiomerOfId":null},"enzymes":[{"id":4,"name":"CYP1A2","conceptId":4312402,"experiment_enzyme_xref":{"enzymeId":4,"experimentId":767}}],"transporters":[],"quantifiedMetabolites":[]},{"id":768,"uid":"NPDI-FQmbtQ","name":"Inhibition of CYP2B6 by G. uralensis Licorice extract","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>&gt; 100 &micro;g/mL</p>","croIdentifier":null,"comment":null,"experimentalConditionsComment":"<p>cocktail assay, IC50 values were determined according to the method of Li et al. 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