[{"id":193,"uid":"NPDI-O4gNrA","name":"A clinical study of transporter-mediated goldenseal drug interactions","napdiIdentifier":null,"overallSummary":"Effects of the goldenseal product on the efflux transporter breast cancer resistance protein (BCRP) and uptake transporters organic anion transporting polypeptide (OATP) 1B1/3, as well as organic anion transporters (OATs), organic cation transporters (OCTs), multidrug and toxin extrusion proteins (MATEs), and CYP3A, were next evaluated in 16 healthy volunteers using a cocktail approach.","pubmedId":33174626,"embaseId":null,"croIdentifier":"DPS-WSU-004","croInformation":"WSU","dateStart":"2018-03-01T00:00:00.000Z","dateEnd":"2020-08-28T00:00:00.000Z","internalComment":"Dates of the study are approximate","status":"published","compoundId":null,"naturalProductUid":"NP-002d7e9a-2baf-47cb-a936-51ba9cbb36a7","naturalProductSampleId":"NPS-gGobKQ","studySourceTypeId":1,"naturalProduct":{"uid":"NP-002d7e9a-2baf-47cb-a936-51ba9cbb36a7","binomial":"Hydrastis canadensis","name":"Goldenseal","itis":null,"srs":"66690655-f406-4d67-96e3-2066aafee8d5","source_id":"","conceptId":null},"compound":null,"studySourceType":{"id":1,"name":"Published report"},"experiments":[{"id":938,"uid":"NPDI-8KuZrA","name":"clinical goldenseal - rosuvastatin acid experiment","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":30,"objectMetaboliteCompoundId":null,"precipitantCompoundId":127,"cytochromeB5Id":null,"studyId":193,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo Interaction","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000071"},"objectCompound":{"id":30,"name":"rosuvastatin","unii":"413KH5ZJ73","inChIKey":"BPRHUIZQVSMCRT-VEUZHWNKSA-N","publicDescription":null,"internalComment":null,"conceptId":1510813,"enantiomerOfId":null},"precipitantCompound":{"id":127,"name":"goldenseal root extract","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[{"id":8,"name":"OATP1B3 (SLCO1B3)","conceptId":null,"experiment_transporter_xref":{"experiment":938,"transporte":8}},{"id":7,"name":"OATP1B1 (SLCO1B1)","conceptId":null,"experiment_transporter_xref":{"experiment":938,"transporte":7}},{"id":1,"name":"BCRP (ABCG2)","conceptId":null,"experiment_transporter_xref":{"experiment":938,"transporte":1}}],"quantifiedMetabolites":[]},{"id":935,"uid":"NPDI-bcNEPw","name":"clinical goldenseal - furosemide experiment","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":"
","objectCompoundId":279,"objectMetaboliteCompoundId":null,"precipitantCompoundId":127,"cytochromeB5Id":null,"studyId":193,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo Interaction","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000071"},"objectCompound":{"id":279,"name":"furosemide","unii":null,"inChIKey":"ZZUFCTLCJUWOSV-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":956874,"enantiomerOfId":null},"precipitantCompound":{"id":127,"name":"goldenseal root extract","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[{"id":6,"name":"OAT3 (SLC22A8)","conceptId":null,"experiment_transporter_xref":{"experiment":935,"transporte":6}},{"id":5,"name":"OAT1 (SLC22A6)","conceptId":null,"experiment_transporter_xref":{"experiment":935,"transporte":5}}],"quantifiedMetabolites":[]},{"id":937,"uid":"NPDI-DboNmw","name":"clinical goldenseal - midazolam experiment","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":26,"objectMetaboliteCompoundId":null,"precipitantCompoundId":127,"cytochromeB5Id":null,"studyId":193,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo Interaction","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000071"},"objectCompound":{"id":26,"name":"midazolam","unii":"R60L0SM5BC","inChIKey":"DDLIGBOFAVUZHB-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":708298,"enantiomerOfId":null},"precipitantCompound":{"id":127,"name":"goldenseal root extract","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[{"id":13,"name":"CYP3A4","conceptId":4306811,"experiment_enzyme_xref":{"enzymeId":13,"experimentId":937}}],"transporters":[],"quantifiedMetabolites":[]},{"id":939,"uid":"NPDI-M015vQ","name":"clinical goldenseal - rosuvastatin lactone experiment","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":280,"objectMetaboliteCompoundId":null,"precipitantCompoundId":127,"cytochromeB5Id":null,"studyId":193,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo Interaction","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000071"},"objectCompound":{"id":280,"name":"rosuvastatin lactone","unii":null,"inChIKey":"SOEGVMSNJOCVHT-VEUZHWNKSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"precipitantCompound":{"id":127,"name":"goldenseal root extract","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[{"id":8,"name":"OATP1B3 (SLCO1B3)","conceptId":null,"experiment_transporter_xref":{"experiment":939,"transporte":8}},{"id":7,"name":"OATP1B1 (SLCO1B1)","conceptId":null,"experiment_transporter_xref":{"experiment":939,"transporte":7}}],"quantifiedMetabolites":[]},{"id":936,"uid":"NPDI-_zSDOQ","name":"clinical goldenseal - metformin study","overallEffect":-1,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":49,"objectMetaboliteCompoundId":null,"precipitantCompoundId":127,"cytochromeB5Id":null,"studyId":193,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo Interaction","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000071"},"objectCompound":{"id":49,"name":"metformin","unii":null,"inChIKey":"XZWYZXLIPXDOLR-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":1503297,"enantiomerOfId":null},"precipitantCompound":{"id":127,"name":"goldenseal root extract","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[{"id":13,"name":"OCT1 (SLC22A1)","conceptId":null,"experiment_transporter_xref":{"experiment":936,"transporte":13}},{"id":10,"name":"OCT2 (SLC22A2)","conceptId":null,"experiment_transporter_xref":{"experiment":936,"transporte":10}},{"id":4,"name":"MATE2-K (SLC47A2)","conceptId":null,"experiment_transporter_xref":{"experiment":936,"transporte":4}},{"id":3,"name":"MATE1 (SLC47A1)","conceptId":null,"experiment_transporter_xref":{"experiment":936,"transporte":3}}],"quantifiedMetabolites":[]}]}]