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The data was entered by RB and reviewed by JY.","status":"published","compoundId":null,"naturalProductUid":"NP-028bf4b2-0bc6-458f-b86f-6930ce40efc6","naturalProductSampleId":null,"studySourceTypeId":1,"naturalProduct":{"uid":"NP-028bf4b2-0bc6-458f-b86f-6930ce40efc6","binomial":"Camellia sinensis","name":"Green tea","itis":null,"srs":"e9698137-24da-46f8-a70e-43e27691491f","source_id":"","conceptId":null},"compound":null,"studySourceType":{"id":1,"name":"Published report"},"experiments":[{"id":4,"uid":"NPDI-mLlCzw","name":"Green tea inhibition of SULT1A1 using 4-nitrophenyl as the substrate","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"Not available","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":"The above results were observed at concentrations of 5 and 10%. At green tea 1%, p-nitrophenol sulfation was significantly inhibited by approximately 90% (estimated from Fig. 4A; P < 0.01).","internalComment":null,"objectCompoundId":42,"objectMetaboliteCompoundId":43,"precipitantCompoundId":35,"cytochromeB5Id":3,"studyId":4,"experimentTypeId":1,"testSystemId":15,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":1,"name":"In Vitro Enzyme Inhibition","isInVitro":true,"isTransporter":false,"isEnzyme":true,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000058"},"objectCompound":{"id":42,"name":"p-nitrophenol","unii":null,"inChIKey":"BTJIUGUIPKRLHP-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"precipitantCompound":{"id":35,"name":"green tea leaf","unii":"W2ZU1RY8B0","inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":{"id":43,"name":"4-nitrophenyl sulfate","unii":null,"inChIKey":"JBGHTSSFSSUKLR-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"enzymes":[{"id":25,"name":"SULT1A1","conceptId":null,"experiment_enzyme_xref":{"enzymeId":25,"experimentId":4}}],"transporters":[],"quantifiedMetabolites":[]},{"id":5,"uid":"NPDI-_Zkjzg","name":"Green tea inhibition of SULT1A3 using dopamine as the substrate","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"Not available","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":"The above results were observed at concentrations of 5 and 10%. At green tea 1%, dopamin sulfation was significantly inhibited by approximately 55% (estimated from Fig. 4B; P < 0.01).","internalComment":null,"objectCompoundId":44,"objectMetaboliteCompoundId":45,"precipitantCompoundId":35,"cytochromeB5Id":3,"studyId":4,"experimentTypeId":1,"testSystemId":15,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":1,"name":"In Vitro Enzyme Inhibition","isInVitro":true,"isTransporter":false,"isEnzyme":true,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000058"},"objectCompound":{"id":44,"name":"dopamine","unii":null,"inChIKey":"VYFYYTLLBUKUHU-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":1337860,"enantiomerOfId":null},"precipitantCompound":{"id":35,"name":"green tea leaf","unii":"W2ZU1RY8B0","inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":{"id":45,"name":"dopamine sulfate","unii":null,"inChIKey":"NWBBWUXCVIJZBG-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"enzymes":[{"id":26,"name":"SULT1A3","conceptId":null,"experiment_enzyme_xref":{"enzymeId":26,"experimentId":5}}],"transporters":[],"quantifiedMetabolites":[]},{"id":132,"uid":"NPDI-OQFZmw","name":"green tea inhibition of SULT1A1 using ritodrine as the substrate","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"Not available","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":40,"objectMetaboliteCompoundId":41,"precipitantCompoundId":35,"cytochromeB5Id":3,"studyId":4,"experimentTypeId":1,"testSystemId":15,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":1,"name":"In Vitro Enzyme Inhibition","isInVitro":true,"isTransporter":false,"isEnzyme":true,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000058"},"objectCompound":{"id":40,"name":"ritodrine","unii":null,"inChIKey":"IOVGROKTTNBUGK-SJCJKPOMSA-N","publicDescription":null,"internalComment":null,"conceptId":1313200,"enantiomerOfId":null},"precipitantCompound":{"id":35,"name":"green tea leaf","unii":"W2ZU1RY8B0","inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":{"id":41,"name":"ritodrine sulfate ester","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"enzymes":[{"id":25,"name":"SULT1A1","conceptId":null,"experiment_enzyme_xref":{"enzymeId":25,"experimentId":132}}],"transporters":[],"quantifiedMetabolites":[]},{"id":133,"uid":"NPDI-L5RmbA","name":"green tea inhibition of SULT1A3 using ritodrine as the substrate","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"Not available","croIdentifier":null,"comment":null,"experimentalConditionsComment":null,"resultsComment":"The above result was observed at 10% of green tea. At green tea 1 and 5%, ritodrine sulfation was significantly inhibited by approximately 25% (estimated from Fig. 2B) and > 95% (P < 0.01 for both), respectively.","internalComment":null,"objectCompoundId":40,"objectMetaboliteCompoundId":41,"precipitantCompoundId":35,"cytochromeB5Id":3,"studyId":4,"experimentTypeId":1,"testSystemId":15,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":1,"name":"In Vitro Enzyme Inhibition","isInVitro":true,"isTransporter":false,"isEnzyme":true,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000058"},"objectCompound":{"id":40,"name":"ritodrine","unii":null,"inChIKey":"IOVGROKTTNBUGK-SJCJKPOMSA-N","publicDescription":null,"internalComment":null,"conceptId":1313200,"enantiomerOfId":null},"precipitantCompound":{"id":35,"name":"green tea leaf","unii":"W2ZU1RY8B0","inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":{"id":41,"name":"ritodrine sulfate ester","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"enzymes":[{"id":26,"name":"SULT1A3","conceptId":null,"experiment_enzyme_xref":{"enzymeId":26,"experimentId":133}}],"transporters":[],"quantifiedMetabolites":[]}]}]