[{"id":13,"uid":"NPDI-S1YNJQ","name":"Inhibitory effects of commonly used herbal extracts on UGT1A1 enzyme activity.","napdiIdentifier":"PMID:20666626","overallSummary":"A panel of nine commonly used herbal supplements were screened for their potential to inhibit UGT1A1 activity using human liver microsomes. The result of green tea constituient epigallocatechin gallate (EGCG) was entered. Based on the in vitro findings, inhibition of  UGT1A1 by EGCG is plausible, particularly in the intestine where higher extract concentrations are anticipated. Further clinical studies are warranted.","pubmedId":20666626,"embaseId":null,"croIdentifier":"University of Florida","croInformation":"Department of Pharmacotherapy and Translational Reserach, University of Florida","dateStart":null,"dateEnd":null,"internalComment":"This is a study reported in the literature. The data was entered by JY and reviewed by JS.","status":"published","compoundId":null,"naturalProductUid":"NP-028bf4b2-0bc6-458f-b86f-6930ce40efc6","naturalProductSampleId":null,"studySourceTypeId":1,"naturalProduct":{"uid":"NP-028bf4b2-0bc6-458f-b86f-6930ce40efc6","binomial":"Camellia sinensis","name":"Green tea","itis":null,"srs":"e9698137-24da-46f8-a70e-43e27691491f","source_id":"","conceptId":null},"compound":null,"studySourceType":{"id":1,"name":"Published report"},"experiments":[{"id":29,"uid":"NPDI-r41Z9w","name":"EGCG inhibition of UGT1A1","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"> 20% inhibition at the highest tested concentrations","croIdentifier":"Y01234","comment":"Concentrations of herbal extracts in screening incubations represent the recommended daily intake (RDI) of each extract dissolved in 53 L, 5.3 L, and 0.53 L. For EGCG, inhibition at the represented RDI was compared with the recommended daily dose (250 mg) of EGCG. The value per dose index (VDI) value was 32.1 L, which is the highest value of all extracts tested, indicating the highest potential for inhibition.","experimentalConditionsComment":"Precipitant concentrations were estimated from Fig. 2.","resultsComment":null,"internalComment":null,"objectCompoundId":57,"objectMetaboliteCompoundId":58,"precipitantCompoundId":19,"cytochromeB5Id":null,"studyId":13,"experimentTypeId":1,"testSystemId":6,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":1,"name":"In Vitro Enzyme Inhibition","isInVitro":true,"isTransporter":false,"isEnzyme":true,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000058"},"objectCompound":{"id":57,"name":"17-beta-estradiol","unii":null,"inChIKey":"VOXZDWNPVJITMN-ZBRFXRBCSA-N","publicDescription":"Synonymns Estradiol; Beta-Estradiol; 17beta-Estradiol; 50-28-2; Oestradiol; Dihydrofolliculin -- https://pubchem.ncbi.nlm.nih.gov/compound/5757","internalComment":null,"conceptId":null,"enantiomerOfId":null},"precipitantCompound":{"id":19,"name":"epigallocatechin gallate","unii":"BQM438CTEL","inChIKey":"WMBWREPUVVBILR-WIYYLYMNSA-N","publicDescription":null,"internalComment":null,"conceptId":19058494,"enantiomerOfId":null},"objectMetaboliteCompound":{"id":58,"name":"17-beta-estradiol-3-o-glucuronide","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"enzymes":[{"id":17,"name":"UGT1A1","conceptId":40782950,"experiment_enzyme_xref":{"enzymeId":17,"experimentId":29}}],"transporters":[],"quantifiedMetabolites":[]}]}]