[{"id":131,"uid":"NPDI-SiYA_A","name":"Drug Approval Package: Epidiolex (Cannabidiol)","napdiIdentifier":"FDA: 210365 Orig 1","overallSummary":"U.S. Food and Drug Administration<br />https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210365Orig1s000TOC.cfm","pubmedId":null,"embaseId":null,"croIdentifier":"GW Research Ltd.","croInformation":"GW Research Ltd.","dateStart":null,"dateEnd":null,"internalComment":null,"status":"published","compoundId":null,"naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","naturalProductSampleId":null,"studySourceTypeId":1,"naturalProduct":{"uid":"NP-0162af79-839e-40e2-af47-361c659061e9","binomial":"Cannabis sativa","name":"Cannabis","itis":null,"srs":"4495dd37-943e-434d-bf30-ea9172d543c8","source_id":"","conceptId":null},"compound":null,"studySourceType":{"id":1,"name":"Published report"},"experiments":[{"id":620,"uid":"NPDI-8_xKYg","name":"CBD Effect on Stiripentol Concentrations","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":"GWEP1543","comment":"<div class=\"page\" title=\"Page 102\">\r\n<div class=\"layoutArea\">\r\n<div class=\"column\">\r\n<p>Study GWEP1543</p>\r\n</div>\r\n</div>\r\n</div>","experimentalConditionsComment":null,"resultsComment":"When CBD was combined with stiripentol there was a minor increase in Cmax and AUCtau; 1.28 and 1.55-fold, respectively.","internalComment":null,"objectCompoundId":202,"objectMetaboliteCompoundId":null,"precipitantCompoundId":115,"cytochromeB5Id":null,"studyId":131,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo 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Day 33:Day ratio for individuals allocated to placebo.<br /><br />CBD did not alter Cmax or AUC of clobazam but did increase exposure to the N-desmethylclobazam metabolite.<br /><br /><span style=\"display: inline !important; float: none; background-color: transparent; color: #000000; cursor: text; font-family: Verdana,Arial,Helvetica,sans-serif; font-size: 14px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;\">Data from page 109</span>","internalComment":null,"objectCompoundId":200,"objectMetaboliteCompoundId":null,"precipitantCompoundId":115,"cytochromeB5Id":null,"studyId":131,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo 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GWEP1543</p>\r\n</div>\r\n</div>\r\n</div>","experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":115,"objectMetaboliteCompoundId":null,"precipitantCompoundId":203,"cytochromeB5Id":null,"studyId":131,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo Interaction","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000071"},"objectCompound":{"id":115,"name":"cannabidiol","unii":null,"inChIKey":"QHMBSVQNZZTUGM-ZWKOTPCHSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"precipitantCompound":{"id":203,"name":"valproic 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GWEP1543</p>\r\n</div>\r\n</div>\r\n</div>","experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":115,"objectMetaboliteCompoundId":null,"precipitantCompoundId":202,"cytochromeB5Id":null,"studyId":131,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo 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GWEP1543</p>\r\n</div>\r\n</div>\r\n</div>","experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":199,"objectMetaboliteCompoundId":null,"precipitantCompoundId":202,"cytochromeB5Id":null,"studyId":131,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo 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metabolite was increased by 3.4 fold as a result of concommitant CBD.","internalComment":null,"objectCompoundId":200,"objectMetaboliteCompoundId":null,"precipitantCompoundId":115,"cytochromeB5Id":null,"studyId":131,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo 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The increased exposure to 1'-hydroxymidazolam may be due to downstream inhibition of glucuronidation by UGT2B7. Further details can be found in \"Clinical Pharmacology Biopharmaceutics Review(s)\"","experimentalConditionsComment":null,"resultsComment":"C estimated from Fig 8; page 111","internalComment":null,"objectCompoundId":26,"objectMetaboliteCompoundId":null,"precipitantCompoundId":115,"cytochromeB5Id":null,"studyId":131,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo 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GWEP1543</p>\r\n</div>\r\n</div>\r\n</div>","experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":115,"objectMetaboliteCompoundId":null,"precipitantCompoundId":200,"cytochromeB5Id":null,"studyId":131,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo 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cursor: text; font-family: Verdana,Arial,Helvetica,sans-serif; font-size: 14px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;\">GWEP1543</span></p>\r\n</div>\r\n</div>\r\n</div>","experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":115,"objectMetaboliteCompoundId":null,"precipitantCompoundId":203,"cytochromeB5Id":null,"studyId":131,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo 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GWEP1543</p>\r\n</div>\r\n</div>\r\n</div>","experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":203,"objectMetaboliteCompoundId":null,"precipitantCompoundId":115,"cytochromeB5Id":null,"studyId":131,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo Interaction","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000071"},"objectCompound":{"id":203,"name":"valproic 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