[{"id":5,"uid":"NPDI-Szj4NQ","name":"Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects.","napdiIdentifier":"PMID:24419562","overallSummary":"This study aimed to evaluate the effects of green tea on the pharmacokinetics and pharmacodynamics of the β-blocker nadolol. The study includes a trasport experiment using cells stably expressing the organic anion–transporting polypeptides OATP1A2 and OATP2B1.","pubmedId":24419562,"embaseId":null,"croIdentifier":"T3","croInformation":"Multiple international academic organizations","dateStart":null,"dateEnd":null,"internalComment":"This is a study reported in the literature. The data was entered by RB and reviewed by JY.","status":"published","compoundId":null,"naturalProductUid":"NP-028bf4b2-0bc6-458f-b86f-6930ce40efc6","naturalProductSampleId":null,"studySourceTypeId":1,"naturalProduct":{"uid":"NP-028bf4b2-0bc6-458f-b86f-6930ce40efc6","binomial":"Camellia sinensis","name":"Green tea","itis":null,"srs":"e9698137-24da-46f8-a70e-43e27691491f","source_id":"","conceptId":null},"compound":null,"studySourceType":{"id":1,"name":"Published report"},"experiments":[{"id":8,"uid":"NPDI-i6A3tw","name":"Green tea interaction with nadolol","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":"T3","comment":"This study suggests that green tea reduces plasma concentrations of nadolol possibly in part by inhibition of OATP1A2-mediated uptake of nadolol in the intestine.","experimentalConditionsComment":null,"resultsComment":"For AUC change, P < 0.001 (currently no such option in the build).","internalComment":null,"objectCompoundId":46,"objectMetaboliteCompoundId":null,"precipitantCompoundId":35,"cytochromeB5Id":null,"studyId":5,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo Interaction","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000071"},"objectCompound":{"id":46,"name":"nadolol","unii":null,"inChIKey":"VWPOSFSPZNDTMJ-UCWKZMIHSA-N","publicDescription":null,"internalComment":null,"conceptId":1313200,"enantiomerOfId":null},"precipitantCompound":{"id":35,"name":"green tea leaf","unii":"W2ZU1RY8B0","inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[{"id":12,"name":"OATP1A2 (SLCO1A2)","conceptId":null,"experiment_transporter_xref":{"experiment":8,"transporte":12}}],"quantifiedMetabolites":[]},{"id":6,"uid":"NPDI-wYUfKA","name":"OATP1A2 in vitro inhibition","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"not clearly specified","croIdentifier":"T3","comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":46,"objectMetaboliteCompoundId":null,"precipitantCompoundId":37,"cytochromeB5Id":null,"studyId":5,"experimentTypeId":5,"testSystemId":22,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":5,"name":"In Vitro Transporter Inhibition","isInVitro":true,"isTransporter":true,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000060"},"objectCompound":{"id":46,"name":"nadolol","unii":null,"inChIKey":"VWPOSFSPZNDTMJ-UCWKZMIHSA-N","publicDescription":null,"internalComment":null,"conceptId":1313200,"enantiomerOfId":null},"precipitantCompound":{"id":37,"name":"(-)-epigallocatechin gallate","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":19},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[{"id":12,"name":"OATP1A2 (SLCO1A2)","conceptId":null,"experiment_transporter_xref":{"experiment":6,"transporte":12}}],"quantifiedMetabolites":[]},{"id":7,"uid":"NPDI-lih1tg","name":"OATP1A2 inhibition with green tea","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"Not provided","croIdentifier":"T3","comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":46,"objectMetaboliteCompoundId":null,"precipitantCompoundId":35,"cytochromeB5Id":null,"studyId":5,"experimentTypeId":5,"testSystemId":22,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":5,"name":"In Vitro Transporter Inhibition","isInVitro":true,"isTransporter":true,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000060"},"objectCompound":{"id":46,"name":"nadolol","unii":null,"inChIKey":"VWPOSFSPZNDTMJ-UCWKZMIHSA-N","publicDescription":null,"internalComment":null,"conceptId":1313200,"enantiomerOfId":null},"precipitantCompound":{"id":35,"name":"green tea leaf","unii":"W2ZU1RY8B0","inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[{"id":12,"name":"OATP1A2 (SLCO1A2)","conceptId":null,"experiment_transporter_xref":{"experiment":7,"transporte":12}}],"quantifiedMetabolites":[]}]}]