Experiment #NPDI-Ww9TTQ CSV JSON

In Vitro Enzyme Induction Experiment

Induction was detected.  Cutoff used — Not specified

Mitragynine

  • CYP2D6 4173631

Cell system HepG2 cell line

Figure 3

Results

CYP2D6 protein expression was found to be increased within the range of 1–5 uM of mitragynine relative to the untreated control. [...] Although the corresponding mRNA expression of CYP2D6 did show slight increase in the mRNA levels, the experiments were not statistically significant for all treatment conditions

Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

Protein expression

0.1, 0.5, 1, 5, 10, 25 uM

48 hours

Control Experiment