[{"id":762,"uid":"NPDI-ZFajng","name":"Goldenseal Metabolomics Experiment","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":"<p>LC-MS metabolomics profiling was employed to compare the chemical composition&nbsp; 35 commercial <em>H. canadensis</em> samples.</p>","experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":null,"cytochromeB5Id":null,"studyId":151,"experimentTypeId":11,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType.id":11,"experimentType.name":"Metabolomics","experimentType.isInVitro":false,"experimentType.isTransporter":false,"experimentType.isEnzyme":false,"experimentType.purl":"http://purl.obolibrary.org/obo/DIDEO_00005005","objectCompound.id":null,"objectCompound.name":null,"objectCompound.unii":null,"objectCompound.inChIKey":null,"objectCompound.publicDescription":null,"objectCompound.internalComment":null,"objectCompound.conceptId":null,"objectCompound.enantiomerOfId":null,"objectCompound.concept.conceptId":null,"objectCompound.concept.conceptName":null,"objectCompound.concept.domainId":null,"objectCompound.concept.vocabularyId":null,"objectCompound.concept.conceptClassId":null,"objectCompound.concept.standardConcept":null,"objectCompound.concept.conceptCode":null,"objectCompound.concept.validStartDate":null,"objectCompound.concept.validEndDate":null,"objectCompound.concept.invalid_reason":null,"precipitantCompound.id":null,"precipitantCompound.name":null,"precipitantCompound.unii":null,"precipitantCompound.inChIKey":null,"precipitantCompound.publicDescription":null,"precipitantCompound.internalComment":null,"precipitantCompound.conceptId":null,"precipitantCompound.enantiomerOfId":null,"precipitantCompound.concept.conceptId":null,"precipitantCompound.concept.conceptName":null,"precipitantCompound.concept.domainId":null,"precipitantCompound.concept.vocabularyId":null,"precipitantCompound.concept.conceptClassId":null,"precipitantCompound.concept.standardConcept":null,"precipitantCompound.concept.conceptCode":null,"precipitantCompound.concept.validStartDate":null,"precipitantCompound.concept.validEndDate":null,"precipitantCompound.concept.invalid_reason":null,"objectMetaboliteCompound.id":null,"objectMetaboliteCompound.name":null,"objectMetaboliteCompound.unii":null,"objectMetaboliteCompound.inChIKey":null,"objectMetaboliteCompound.publicDescription":null,"objectMetaboliteCompound.internalComment":null,"objectMetaboliteCompound.conceptId":null,"objectMetaboliteCompound.enantiomerOfId":null,"objectMetaboliteCompound.concept.conceptId":null,"objectMetaboliteCompound.concept.conceptName":null,"objectMetaboliteCompound.concept.domainId":null,"objectMetaboliteCompound.concept.vocabularyId":null,"objectMetaboliteCompound.concept.conceptClassId":null,"objectMetaboliteCompound.concept.standardConcept":null,"objectMetaboliteCompound.concept.conceptCode":null,"objectMetaboliteCompound.concept.validStartDate":null,"objectMetaboliteCompound.concept.validEndDate":null,"objectMetaboliteCompound.concept.invalid_reason":null,"enzymes.id":null,"enzymes.name":null,"enzymes.conceptId":null,"enzymes.experiment_enzyme_xref.enzymeId":null,"enzymes.experiment_enzyme_xref.experimentId":null,"transporters.id":null,"transporters.name":null,"transporters.conceptId":null,"transporters.experiment_transporter_xref.experimentId":null,"transporters.experiment_transporter_xref.transporterId":null,"quantifiedMetabolites.id":null,"quantifiedMetabolites.name":null,"quantifiedMetabolites.unii":null,"quantifiedMetabolites.inChIKey":null,"quantifiedMetabolites.publicDescription":null,"quantifiedMetabolites.internalComment":null,"quantifiedMetabolites.conceptId":null,"quantifiedMetabolites.enantiomerOfId":null,"quantifiedMetabolites.experiment_quantified_metabolite_xref.com":null,"quantifiedMetabolites.experiment_quantified_metabolite_xref.exp":null,"study.id":151,"study.uid":"NPDI-sv6smA","study.name":"Goldenseal Metabolomics","study.napdiIdentifier":null,"study.overallSummary":"LC-MS metablomics and composite score analysis [1,2] was used to compare the chemical composition of 35 commercial <em>H. canadensis </em><a>samples. A single sample </a>(dried <em>Hydrastis canadensis </em>room material, arbitrarily identified as GS-16) was chosen for use in pharmacology studies based on its similarity to authentic reference standards and to other commercially used goldenseal supplements. <em><em> <br /><br /></em></em>\r\n<p class=\"gmail-MsoCommentText\">1. Joshua J. Kellogg, Olav M. Kvalheim, Nadja B. Cech, Composite score analysis for unsupervised comparison and network visualization of metabolomics data,Analytica Chimica Acta, Volume 1095, 2020, Pages 38-47, ISSN 0003-2670, <a href=\"https://nam05.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdoi.org%2F10.1016%2Fj.aca.2019.10.029&amp;data=02%7C01%7Crdb20%40pitt.edu%7C6354678139bb4602440508d8280976ef%7C9ef9f489e0a04eeb87cc3a526112fd0d%7C1%7C0%7C637303368412457146&amp;sdata=RM%2FGVRtBftE3IYdTriX0%2Fqrn%2FB6Nv%2Bm2rsmJ1ixXmnc%3D&amp;reserved=0\">https://doi.org/10.1016/j.aca.2019.10.029</a>.<br /><br />2. Wallace ED, Oberlies NH, Cech NB, Kellogg JJ. Detection of adulteration in Hydrastis canadensis (goldenseal) dietary supplements via untargeted mass spectrometry-based metabolomics. Food Chem Toxicol. 2018;120:439-447. doi:10.1016/j.fct.2018.07.033. </p>\r\n<em><br /><br /></em>","study.pubmedId":null,"study.embaseId":null,"study.croIdentifier":"UNCG","study.croInformation":"University of North Carolina - Greensboro","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-002d7e9a-2baf-47cb-a936-51ba9cbb36a7","study.naturalProductSampleId":null,"study.studySourceTypeId":2,"study.naturalProduct.uid":"NP-002d7e9a-2baf-47cb-a936-51ba9cbb36a7","study.naturalProduct.binomial":"Hydrastis 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