Experiment #NPDI-_rs20g CSV JSON

In Vitro Enzyme Induction Experiment

Non-induction was detected.  Cutoff used — Not specified

dimethyl sulfoxide

  • CYP1A2 4312402
  • CYP2D6 4173631
  • CYP3A4 4306811

Cell system HepG2 cell line

Fig. 3. Positive controls and results:

  • CYP1A2: 50 uM omeprazole, mean ~1.2 ± 0.2-fold, n = 2
  • CYP2D6: 5uM quinidine, mean ~1.2 ± 0.1 fold, n = 2
  • CYP3A4: 5uM dexamethasone, mean ~1.2 ± 0.1 fold, n = 2
  • No p value reported for positive controls

Results

Figure 3. P-value not reported. 
Positive controls and results:

  • CYP1A2: 50 uM omeprazole, mean ~1.2 ± 0.2-fold, n = 2
  • CYP2D6: 5uM quinidine, mean ~1.2 ± 0.1 fold, n = 2
  • CYP3A4: 5uM dexamethasone, mean ~1.2 ± 0.1 fold, n = 2
  • No p value reported for positive controls

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

Protein expression

48 hours