[{"id":75,"uid":"NPDI-fLne_g","name":"Influence of Goldenseal Root on the Pharmacokinetics of Indinavir","napdiIdentifier":"PMID: 14551183","overallSummary":"<div class=\"page\" title=\"Page 1\">\r\n<div class=\"layoutArea\">\r\n<div class=\"column\">\r\n<p>Goldenseal root was identified as the most potent inhibitor of CYP3A4 in a study that tested 21 popular herbal products for in vitro inhibitory activity. The purpose of this investigation was to examine the influence of goldenseal root on the dispo- sition of the CYP3A4 substrate indinavir in humans. Using a crossover study design, the pharmacokinetics of indinavir were characterized in 10 healthy volunteers before and after 14 days of treatment with goldenseal root (1140 mg twice daily). Indinavir was given as a single 800-mg oral dose, and blood samples were collected for 8 hours following the dose. No statistically significant differences in peak concentration (11.6 vs. 11.9 mg/L) or oral clearance (26.8 vs. 23.9 mg•h/L) were observed following treatment with goldenseal root. Half-life and time to reach peak concentration were also un- changed by goldenseal. These results suggest that patients being treated with indinavir can safely take goldenseal root and that interactions with other drugs metabolized by CYP3A4 in the liver are unlikely.</p>\r\n</div>\r\n</div>\r\n</div>","pubmedId":14551183,"embaseId":null,"croIdentifier":"Eugene Applebaum College of Pharmacy and Health Sciences","croInformation":"Department of Pharmacy Practice","dateStart":null,"dateEnd":null,"internalComment":null,"status":"published","compoundId":null,"naturalProductUid":"NP-002d7e9a-2baf-47cb-a936-51ba9cbb36a7","naturalProductSampleId":null,"studySourceTypeId":1,"naturalProduct":{"uid":"NP-002d7e9a-2baf-47cb-a936-51ba9cbb36a7","binomial":"Hydrastis canadensis","name":"Goldenseal","itis":null,"srs":"66690655-f406-4d67-96e3-2066aafee8d5","source_id":"","conceptId":null},"compound":null,"studySourceType":{"id":1,"name":"Published report"},"experiments":[{"id":302,"uid":"NPDI-0eAs4g","name":"Indinavir/ Goldenseal Root Experiment","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":null,"experimentalConditionsComment":"Indinavir was administered on an empty stomach with 200 mL tap water following an overnight fast. \r\n<div class=\"page\" title=\"Page 2\">\r\n<div class=\"layoutArea\">\r\n<div class=\"column\">\r\n<p>A standard lunch (ham or turkey sandwich, potato salad, coleslaw, soft drink) was served following the 4-hour blood sample.</p>\r\n</div>\r\n</div>\r\n</div>","resultsComment":"Table 1<br />Converted Cmax from mg/L (in study) to ng/mL (shown above)","internalComment":null,"objectCompoundId":130,"objectMetaboliteCompoundId":null,"precipitantCompoundId":127,"cytochromeB5Id":null,"studyId":75,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo Interaction","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000071"},"objectCompound":{"id":130,"name":"indinavir","unii":null,"inChIKey":"CBVCZFGXHXORBI-PXQQMZJSSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"precipitantCompound":{"id":127,"name":"goldenseal root extract","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[{"id":13,"name":"CYP3A4","conceptId":4306811,"experiment_enzyme_xref":{"enzymeId":13,"experimentId":302}}],"transporters":[],"quantifiedMetabolites":[]}]}]