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Phytochemicals could be the AhR agonists and induction of AhR could play a role in herb-drug interation.</p>","pubmedId":36017806,"embaseId":null,"croIdentifier":"NCNPR-PXR-AHR-boswellia-1","croInformation":"Natural Center for Natural Products Research","dateStart":null,"dateEnd":null,"internalComment":null,"status":"published","compoundId":null,"naturalProductUid":"NP-5584e0e5-defc-426c-a06e-fa2f05450b4d","naturalProductSampleId":null,"studySourceTypeId":1,"naturalProduct":{"uid":"NP-5584e0e5-defc-426c-a06e-fa2f05450b4d","binomial":"Boswellia serrata","name":"Boswellia","itis":null,"srs":"87165bbf-7ee6-47d8-85b8-ebaacb7d5f97","source_id":"","conceptId":null},"compound":null,"studySourceType":{"id":1,"name":"Published report"},"experiments":[{"id":1132,"uid":"NPDI-Lp10Hw","name":"Boswellia - In Vitro Nuclear Receptor Induction PXR Experiment - 1","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>An activation of 2-folds or higher.</p>","croIdentifier":"ole-miss-boswellia-pxr-induction-1","comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":319,"cytochromeB5Id":null,"studyId":793,"experimentTypeId":13,"testSystemId":45,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":13,"name":"In Vitro Nuclear Receptor Induction","isInVitro":true,"isTransporter":false,"isEnzyme":true,"purl":"http://purl.obolibrary.org/obo/DIDEO_999999991"},"objectCompound":null,"precipitantCompound":{"id":319,"name":"boswellia extract","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[{"id":39,"name":"Pregnane X receptor (PXR)","conceptId":null,"experiment_enzyme_xref":{"enzymeId":39,"experimentId":1132}}],"transporters":[],"quantifiedMetabolites":[]},{"id":1133,"uid":"NPDI-VHfKlA","name":"Boswellia - 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