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Phytochemicals could be the AhR agonists and induction of AhR could play a role in herb-drug interation.</p>","pubmedId":36017806,"embaseId":null,"croIdentifier":"NCNPR-PXR-AHR-hemp-lowCBD-1","croInformation":"Natural Center for Natural Products Research","dateStart":null,"dateEnd":null,"internalComment":null,"status":"published","compoundId":null,"naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","naturalProductSampleId":null,"studySourceTypeId":1,"naturalProduct":{"uid":"NP-0162af79-839e-40e2-af47-361c659061e9","binomial":"Cannabis sativa","name":"Cannabis","itis":null,"srs":"4495dd37-943e-434d-bf30-ea9172d543c8","source_id":"","conceptId":null},"compound":null,"studySourceType":{"id":1,"name":"Published report"},"experiments":[{"id":1144,"uid":"NPDI-J5kRAA","name":"Hemp (low CBD) - In Vitro Nuclear Receptor Induction PXR Experiment - 1","overallEffect":1,"isControlData":false,"isIc50Shift":false,"croCutoff":"<p>An activation of 2-folds or higher.</p>","croIdentifier":"ole-miss-lowCBD-pxr-induction-1","comment":null,"experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":336,"cytochromeB5Id":null,"studyId":795,"experimentTypeId":13,"testSystemId":45,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":13,"name":"In Vitro Nuclear Receptor Induction","isInVitro":true,"isTransporter":false,"isEnzyme":true,"purl":"http://purl.obolibrary.org/obo/DIDEO_999999991"},"objectCompound":null,"precipitantCompound":{"id":336,"name":"hemp (low CBD) extract","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[{"id":39,"name":"Pregnane X receptor (PXR)","conceptId":null,"experiment_enzyme_xref":{"enzymeId":39,"experimentId":1144}}],"transporters":[],"quantifiedMetabolites":[]},{"id":1145,"uid":"NPDI-JHa2CQ","name":"Hemp (low CBD) - 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