[{"id":151,"uid":"NPDI-sv6smA","name":"Goldenseal Metabolomics","napdiIdentifier":null,"overallSummary":"LC-MS metablomics and composite score analysis [1,2] was used to compare the chemical composition of 35 commercial <em>H. canadensis </em><a>samples. A single sample </a>(dried <em>Hydrastis canadensis </em>room material, arbitrarily identified as GS-16) was chosen for use in pharmacology studies based on its similarity to authentic reference standards and to other commercially used goldenseal supplements. <em><em> <br /><br /></em></em>\r\n<p class=\"gmail-MsoCommentText\">1. Joshua J. Kellogg, Olav M. Kvalheim, Nadja B. Cech, Composite score analysis for unsupervised comparison and network visualization of metabolomics data,Analytica Chimica Acta, Volume 1095, 2020, Pages 38-47, ISSN 0003-2670, <a href=\"https://nam05.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdoi.org%2F10.1016%2Fj.aca.2019.10.029&amp;data=02%7C01%7Crdb20%40pitt.edu%7C6354678139bb4602440508d8280976ef%7C9ef9f489e0a04eeb87cc3a526112fd0d%7C1%7C0%7C637303368412457146&amp;sdata=RM%2FGVRtBftE3IYdTriX0%2Fqrn%2FB6Nv%2Bm2rsmJ1ixXmnc%3D&amp;reserved=0\">https://doi.org/10.1016/j.aca.2019.10.029</a>.<br /><br />2. Wallace ED, Oberlies NH, Cech NB, Kellogg JJ. Detection of adulteration in Hydrastis canadensis (goldenseal) dietary supplements via untargeted mass spectrometry-based metabolomics. Food Chem Toxicol. 2018;120:439-447. doi:10.1016/j.fct.2018.07.033. </p>\r\n<em><br /><br /></em>","pubmedId":null,"embaseId":null,"croIdentifier":"UNCG","croInformation":"University of North Carolina - Greensboro","dateStart":null,"dateEnd":null,"internalComment":null,"status":"published","compoundId":null,"naturalProductUid":"NP-002d7e9a-2baf-47cb-a936-51ba9cbb36a7","naturalProductSampleId":null,"studySourceTypeId":2,"naturalProduct":{"uid":"NP-002d7e9a-2baf-47cb-a936-51ba9cbb36a7","binomial":"Hydrastis canadensis","name":"Goldenseal","itis":null,"srs":"66690655-f406-4d67-96e3-2066aafee8d5","source_id":"","conceptId":null},"compound":null,"studySourceType":{"id":2,"name":"Manuscript prepared or submitted for peer-reviewed publication"},"experiments":[{"id":762,"uid":"NPDI-ZFajng","name":"Goldenseal Metabolomics Experiment","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":"<p>LC-MS metabolomics profiling was employed to compare the chemical composition&nbsp; 35 commercial <em>H. canadensis</em> samples.</p>","experimentalConditionsComment":null,"resultsComment":null,"internalComment":null,"objectCompoundId":null,"objectMetaboliteCompoundId":null,"precipitantCompoundId":null,"cytochromeB5Id":null,"studyId":151,"experimentTypeId":11,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":11,"name":"Metabolomics","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00005005"},"objectCompound":null,"precipitantCompound":null,"objectMetaboliteCompound":null,"enzymes":[],"transporters":[],"quantifiedMetabolites":[]}]}]