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\r\n
\r\n
\r\n

\"Psychomimetic symptoms were measured using the PANSS, as described by Kay et al. (1987). [...] To determine other potentially confounding CNS effects, an extensive test battery (NeuroCart) was used, which included VAS, eye movements, postural stability, pupil/iris ratio, Stroop colour word test and the visual verbal learning test (VVLT), extended with measurements of serum cortisol and prolactin. All these measurements were performed repeatedly throughout the study day, including two baseline measurements. The timing of meas- urements was very similar to the scheme used by Liem-Moolenaar et al.\"

All of the aforementioned are described in further detail in the Outcome Measures section in the text.

\r\n
\r\n
\r\n
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The dopaminergic antagonist haloperidol has previously been shown to reduce these effects. This placebo-controlled, cross-over study in 49 healthy, male, mild cannabis users aimed to further explore this model by examining the effect of a single oral dose of olanzapine (with dopaminergic, serotonergic, adrenergic, muscarinergic and histaminergic properties) or two oral doses of diphenhydramine (histamine antagonist) on the effects of intrapulmonarily administered THC. Transient psychomimetic symptoms were seen after THC administration, as measured on the positive and negative syndrome scale (20.6% increase on positive subscale, p<0.001) and the visual analogue scale for psychedelic effects (increase of 10.7 mm on feeling high). Following the combination of THC and olanzapine, the positive subscale increased by only 13.7% and feeling high by only 8.7 mm. This reduction of THC effects on the positive subscale failed to reach statistical significance (p=0.066). 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