[{"id":66,"uid":"NPDI-xYeUJQ","name":"Influence of cannabidiol on secobarbital effects and plasma kinetics","napdiIdentifier":"PMID: 791563","overallSummary":"<div class=\"page\" title=\"Page 1\">\r\n<div class=\"layoutArea\">\r\n<div class=\"column\">\r\n<p>To investigate the possible metabolic interaction between cannabidiol (CBD) and secobarbital, 6 male volunteers received 150 mg/70 kg sodium secobarbital orally immediately after smoking a marihuana cigarette prepared to deliver 0, 150, or 500 µg/kg CBD. The study was performed in a double-blind manner with each of the three treatments being assigned to every subject. Clinical effects and plasma secobarbital concentrations were recorded at periodic intervals. CBD did not alter the summary parameters which describe the secobarbital plasma concentration time curve. Secobarbital half-life, peak concentration, time of peak concentration, and area under the curve were unchanged by the coadministration of CBD. Clinical effects of secobarbital were also unaltered by CBD pretreatment. Thus at the doses administered, CBD does not appear to inhibit secobarbital metabolism in man.</p>\r\n</div>\r\n</div>\r\n</div>","pubmedId":791563,"embaseId":null,"croIdentifier":"Indiana University School of Medicine","croInformation":"Indiana University School of Medicine","dateStart":null,"dateEnd":null,"internalComment":null,"status":"published","compoundId":null,"naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","naturalProductSampleId":null,"studySourceTypeId":1,"naturalProduct":{"uid":"NP-0162af79-839e-40e2-af47-361c659061e9","binomial":"Cannabis sativa","name":"Cannabis","itis":null,"srs":"4495dd37-943e-434d-bf30-ea9172d543c8","source_id":"","conceptId":null},"compound":null,"studySourceType":{"id":1,"name":"Published report"},"experiments":[{"id":292,"uid":"NPDI-tUG7XA","name":"Plasma Concentrations of Secobarbital After Placebo Pretreatment and Oral Administration of Secobarbital","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":"Table 1.","experimentalConditionsComment":null,"resultsComment":"Values converted from µg/mL. <br />Original value: C<sub>max</sub> (µg/mL): 2.59 ± 0.94<br />Table 1.","internalComment":null,"objectCompoundId":126,"objectMetaboliteCompoundId":null,"precipitantCompoundId":117,"cytochromeB5Id":null,"studyId":66,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo Interaction","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000071"},"objectCompound":{"id":126,"name":"secobarbital","unii":null,"inChIKey":"KQPKPCNLIDLUMF-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"precipitantCompound":{"id":117,"name":"placebo","unii":null,"inChIKey":null,"publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[],"quantifiedMetabolites":[]},{"id":293,"uid":"NPDI-noOe3w","name":"Secobarbital Plasma Concentrations Following Sodium Secobarbital Ingestion and 150 µg/kg CBD Pretreatment","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":"Figure 1","experimentalConditionsComment":null,"resultsComment":"Values estimated from Figure 1 and converted from µg/mL. Original estimated value: 2.5 µg/mL.","internalComment":null,"objectCompoundId":126,"objectMetaboliteCompoundId":null,"precipitantCompoundId":118,"cytochromeB5Id":null,"studyId":66,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo Interaction","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000071"},"objectCompound":{"id":126,"name":"secobarbital","unii":null,"inChIKey":"KQPKPCNLIDLUMF-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"precipitantCompound":{"id":118,"name":"delta-9-tetrahydrocannabinol","unii":null,"inChIKey":"CYQFCXCEBYINGO-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[],"quantifiedMetabolites":[]},{"id":294,"uid":"NPDI-SCT2WA","name":"Secobarbital Plasma Concentrations Following Sodium Secobarbital Ingestion and 500 µg/kg CBD Pretreatment","overallEffect":0,"isControlData":false,"isIc50Shift":false,"croCutoff":null,"croIdentifier":null,"comment":"Figure 1","experimentalConditionsComment":null,"resultsComment":"Values estimated from Figure 1. Original value was converted to ng/mL: C<sub>max</sub> (µg/mL): 2.75","internalComment":null,"objectCompoundId":126,"objectMetaboliteCompoundId":null,"precipitantCompoundId":118,"cytochromeB5Id":null,"studyId":66,"experimentTypeId":9,"testSystemId":null,"ic50ShiftExperimentId":null,"controlDataExperimentId":null,"controlDataForExperimentId":null,"naturalProductSampleId":null,"experimentType":{"id":9,"name":"In Vivo Interaction","isInVitro":false,"isTransporter":false,"isEnzyme":false,"purl":"http://purl.obolibrary.org/obo/DIDEO_00000071"},"objectCompound":{"id":126,"name":"secobarbital","unii":null,"inChIKey":"KQPKPCNLIDLUMF-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"precipitantCompound":{"id":118,"name":"delta-9-tetrahydrocannabinol","unii":null,"inChIKey":"CYQFCXCEBYINGO-UHFFFAOYSA-N","publicDescription":null,"internalComment":null,"conceptId":null,"enantiomerOfId":null},"objectMetaboliteCompound":null,"enzymes":[],"transporters":[],"quantifiedMetabolites":[]}]}]