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Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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mg for first treatment, 135 mg or as per previous response for second treatment","experimentAnswers.answerId":null,"experimentAnswers.experimentId":308,"experimentAnswers.questionId":110,"experimentAnswers.question.id":110,"experimentAnswers.question.text":"Total daily dose","experimentAnswers.question.required":true,"experimentAnswers.question.maxAnswers":null,"experimentAnswers.question.type":"STRING","experimentAnswers.question.conceptId":null,"experimentAnswers.question.answers.id":null,"experimentAnswers.question.answers.text":null,"experimentAnswers.question.answers.sortOrder":null,"experimentAnswers.question.answers.conceptId":null,"experimentAnswers.question.answers.questionId":null,"experimentAnswers.answer.id":null,"experimentAnswers.answer.text":null,"experimentAnswers.answer.sortOrder":null,"experimentAnswers.answer.conceptId":null,"experimentAnswers.answer.questionId":null},{"id":308,"uid":"NPDI-yqEgVA","name":"Docetaxel PK ± medicinal 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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wers.answer.conceptId":null,"experimentAnswers.answer.questionId":null},{"id":308,"uid":"NPDI-yqEgVA","name":"Docetaxel 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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for Medicinal Cannabis, The Hague, The Netherlands","experimentAnswers.answerId":null,"experimentAnswers.experimentId":308,"experimentAnswers.questionId":118,"experimentAnswers.question.id":118,"experimentAnswers.question.text":"Manufacturer/source","experimentAnswers.question.required":false,"experimentAnswers.question.maxAnswers":null,"experimentAnswers.question.type":"STRING","experimentAnswers.question.conceptId":null,"experimentAnswers.question.answers.id":null,"experimentAnswers.question.answers.text":null,"experimentAnswers.question.answers.sortOrder":null,"experimentAnswers.question.answers.conceptId":null,"experimentAnswers.question.answers.questionId":null,"experimentAnswers.answer.id":null,"experimentAnswers.answer.text":null,"experimentAnswers.answer.sortOrder":null,"experimentAnswers.answer.conceptId":null,"experimentAnswers.answer.questionId":null},{"id":308,"uid":"NPDI-yqEgVA","name":"Docetaxel PK ± medicinal 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel","study.napdiIdentifier":"PMID: 17405893","study.overallSummary":"<h4>OBJECTIVE:</h4>\r\n<p>To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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Recently, a standardized medicinal <span class=\"highlight\">cannabis</span> product was introduced in The Netherlands. We anticipated an increased use of medicinal <span class=\"highlight\">cannabis</span> concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal <span class=\"highlight\">cannabis</span> on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.</p>\r\n<h4>PATIENTS AND METHODS:</h4>\r\n<p>Twenty-four cancer patients were treated with i.v. irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal <span class=\"highlight\">cannabis</span> (200 ml herbal tea, 1 g/l) for 15 consecutive days, starting 12 days before the second treatment. Blood samples were obtained up to 55 hours after dosing and analyzed for irinotecan and its metabolites (SN-38, SN-38G), respectively, or docetaxel. Pharmacokinetic analyses were performed during both treatments. Results are reported as the mean ratio (95% confidence interval [CI]) of the observed pharmacokinetic parameters with and without concomitant medicinal <span class=\"highlight\">cannabis</span>.</p>\r\n<h4>RESULTS:</h4>\r\n<p>Medicinal <span class=\"highlight\">cannabis</span> administration did not significantly influence exposure to and clearance of irinotecan (1.04; CI, 0.96-1.11 and 0.97; CI, 0.90-1.05, respectively) or docetaxel (1.11; CI, 0.94-1.28 and 0.95; CI, 0.82-1.08, respectively).</p>\r\n<h4>CONCLUSION:</h4>\r\n<p>Coadministration of medicinal <span class=\"highlight\">cannabis</span>, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal <span class=\"highlight\">cannabis</span> can be administered concomitantly with both anticancer agents without dose adjustments.</p>","study.pubmedId":17405893,"study.embaseId":null,"study.croIdentifier":"Erasmus MC University Medical Center Rotterdam","study.croInformation":"Erasmus MC University Medical Center Rotterdam","study.dateStart":null,"study.dateEnd":null,"study.internalComment":null,"study.status":"published","study.compoundId":null,"study.naturalProductUid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProductSampleId":null,"study.studySourceTypeId":1,"study.naturalProduct.uid":"NP-0162af79-839e-40e2-af47-361c659061e9","study.naturalProduct.binomial":"Cannabis 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