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  • Cannabis (Cannabis sativa)

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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-RPqAvQ Cannabis (Cannabis sativa) Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes 6-alpha-OH-CBD-quinidine In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2D6
cannabidiol (cbd) 6α-oh-cannabidiol quinidine
NPDI-otngFw Cannabis (Cannabis sativa) Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes 6-alpha-OH-CBD-ketoconazole In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
cannabidiol (cbd) 6α-oh-cannabidiol ketoconazole
NPDI-AWv-_A Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) Valproic Acid Effect on CBD In Vivo Interaction positive — PK Interaction – Decreased systemic exposure
cannabidiol (cbd) valproic acid
NPDI-4EVwQw Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) Clobazam Effect on CBD In Vivo Interaction negative — No Effect (based on bioequivalence limits)
cannabidiol (cbd) clobazam
NPDI-tjxX2A Cannabis (Cannabis sativa) Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes 6-alpha-OH-CBD-sulfaphenazole In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2C9
cannabidiol (cbd) 6α-oh-cannabidiol sulfaphenazole
NPDI-jJ11Ig Cannabis (Cannabis sativa) Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes 6-alpha-OH-CBD-omeprazole In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
cannabidiol (cbd) 6α-oh-cannabidiol omeprazole
NPDI-2TMzVA Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) Stiripentol Effect on CBD, 6-OH-CBD, and 7-COOH-CBD In Vivo Interaction negative — No Effect (based on bioequivalence limits)
cannabidiol (cbd) stiripentol
NPDI-6v65qQ Cannabis (Cannabis sativa) Pharmacological Effects of Cannabinoids on the Caco-2 Cell Culture Model of Intestinal Permeability CBD In Vitro Transporter Kinetics positive — In Vitro Transport
  • P-gp (ABCB1)
cannabidiol (cbd)
NPDI-AEDMtg Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) Valproic Acid Effect on Cannabidiol Metabolites In Vivo Interaction negative — No Effect (based on bioequivalence limits)
cannabidiol (cbd) valproic acid
NPDI-ILAq5w Cannabis (Cannabis sativa) Cannabidiol Is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19 CBD-omeprazole In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
omeprazole 5-hydroxyomeprazole cannabidiol (cbd)
NPDI-kJ7mIQ Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) CBD effect on CLB and N-desmethylclobazam In Vivo Interaction positive — PK Interaction – Increased systemic exposure
clobazam cannabidiol (cbd)
NPDI-Y9U8Tw Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) CBD Effect on clobazam and N-desmethylclobazam In Vivo Interaction negative — No Effect (based on bioequivalence limits)
clobazam cannabidiol (cbd)
NPDI-wM7_CQ Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) CBD Effect on Valproic Acid Concentrations In Vivo Interaction negative — No Effect (based on bioequivalence limits)
valproic acid cannabidiol (cbd)
NPDI-BfJ7dA Cannabis (Cannabis sativa) Structural requirements for potent direct inhibition of human cytochrome P450 1A1 by cannabidiol: role of pentylresorcinol moiety. Cannabidiol In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin cannabidiol (cbd)
NPDI-8_xKYg Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) CBD Effect on Stiripentol Concentrations In Vivo Interaction positive — PK Interaction – Increased systemic exposure
stiripentol cannabidiol (cbd)
NPDI-dh6TjQ Cannabis (Cannabis sativa) Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse CBD-UGT1A9 Inhibition In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A9
ethanol ethyl glucuronide cannabidiol (cbd)
NPDI-3VIAiw Cannabis (Cannabis sativa) Cannabidiol enhances xenobiotic permeability through the human placental barrier by direct inhibition of breast cancer resistance protein: an ex vivo study. Jar: CBD-Mitoxantrone In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • BCRP (ABCG2)
mitoxantrone cannabidiol (cbd)
NPDI-Q2pa5g Cannabis (Cannabis sativa) CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells CBD In Vitro Transporter Induction positive — In Vitro Transporter Induction
  • P-gp (ABCB1)
cannabidiol (cbd)
NPDI-4htiMA Cannabis (Cannabis sativa) Cannabidiol enhances xenobiotic permeability through the human placental barrier by direct inhibition of breast cancer resistance protein: an ex vivo study. BeWo: CBD-mitoxantrone In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • BCRP (ABCG2)
mitoxantrone cannabidiol (cbd)
NPDI-GRyerw Cannabis (Cannabis sativa) Cannabidiol enhances xenobiotic permeability through the human placental barrier by direct inhibition of breast cancer resistance protein: an ex vivo study. MCF7/P-gp: CBD-mitoxantrone In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
mitoxantrone cannabidiol (cbd)
NPDI-dvyC1w Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. iHLMs: CBD-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin cannabidiol (cbd)
NPDI-UlPhZQ Cannabis (Cannabis sativa) Safety and pharmacokinetics of oral cannabidiol when administered concomitantly with intravenous fentanyl in humans Plasma CBD Concentrations In Vivo Interaction negative — No Effect (based on bioequivalence limits)
fentanyl cannabidiol (cbd)
NPDI-b6F8pQ Cannabis (Cannabis sativa) Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol Cannabidiol In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin cannabidiol (cbd)
NPDI-F2AXtQ Cannabis (Cannabis sativa) Cannabidiol Is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19 CBD-OMF In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
3-o-methylfluorescein fluorescein cannabidiol (cbd)
NPDI-ILsKWw Cannabis (Cannabis sativa) Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse CBD on ethanol glucuronidation In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT
ethanol ethyl glucuronide cannabidiol (cbd)
NPDI-DpYeow Cannabis (Cannabis sativa) Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse CBD-UGT2B7 Inhibition In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT2B7
ethanol ethyl glucuronide cannabidiol (cbd)
NPDI-XouN0Q Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. pHLM: CBD-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin cannabidiol (cbd)
NPDI-es-pWA Cannabis (Cannabis sativa) Cannabidiol Is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19 CBD-(S)-Mephenytoin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- cannabidiol (cbd)
NPDI-P2rdYg Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. rCYP2C9: CBD-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin cannabidiol (cbd)
NPDI-Fqa3JA Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. iHLM: CBD-diclofenac In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac cannabidiol (cbd)
NPDI-LKS7Ow Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. rCYP2C9: CBD-diclofenac In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac cannabidiol (cbd)
NPDI-THQe_g Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Recombinant: CBD-dextromethorphan In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan cannabidiol (cbd)
NPDI-ckGWRw Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. pHLM: CBD-dextromethorphan In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan cannabidiol (cbd)
NPDI-8jlF2g Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Recombinant: CBD-AMMC In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-methoxy-4-methylcoumarin 3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-hydroxy-4-methylcoumarin cannabidiol (cbd)
NPDI-FmAizA Cannabis (Cannabis sativa) Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. CYP3A4-CBD In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
diltiazem n-demethyldiltiazem cannabidiol (cbd)
NPDI-zkYApA Cannabis (Cannabis sativa) Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. HLM-CBD In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
diltiazem n-demethyldiltiazem cannabidiol (cbd)
NPDI-ZFfQJg Cannabis (Cannabis sativa) The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids. Mitoxantrone-CBD In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • BCRP (ABCG2)
mitoxantrone cannabidiol (cbd)
NPDI-FompNA Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes 1A2: CBD In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A2
7-ethoxyresorufin resorufin cannabidiol (cbd)
NPDI-jYDUsw Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes 1A1: CBD In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin cannabidiol (cbd)
NPDI-bxWjqg Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes HLMs: CBD In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin cannabidiol (cbd)
NPDI-pvvgAw Cannabis (Cannabis sativa) Characterization of P-glycoprotein Inhibition by Major Cannabinoids from Marijuana CBD-Rh123 (Flow-Cytometry Assay) In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
rhodamine 123 cannabidiol (cbd)
NPDI-gOdMHw Cannabis (Cannabis sativa) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. CCRF-CEM: CBD In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • P-gp (ABCB1)
rhodamine 123 cannabidiol (cbd)
NPDI-UIHjqQ Cannabis (Cannabis sativa) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. CEM/VLB100: CBD In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • P-gp (ABCB1)
rhodamine 123 cannabidiol (cbd)
NPDI-_jX3DQ Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) CBD Effect on N-desmethylclobazam Concentrations In Vivo Interaction positive — PK Interaction – Increased systemic exposure
n-desmethylclobazam cannabidiol (cbd)
NPDI-d2rDLg Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) CBD Effect on Midazolam In Vivo Interaction negative — No Effect (based on bioequivalence limits)
midazolam cannabidiol (cbd)
NPDI-soqMrQ Cannabis (Cannabis sativa) Cannabis Characterization of Bulk Plant Material Cannabis bulk plant Characterization of Material Characterization of Material
ID Subject of Study Name
NPDI-zlH6uA Cannabis (Cannabis sativa) Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes
NPDI-SiYA_A Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol)
NPDI-BvR0Pw Cannabis (Cannabis sativa) Pharmacological Effects of Cannabinoids on the Caco-2 Cell Culture Model of Intestinal Permeability
NPDI-CAApFQ Cannabis (Cannabis sativa) Cannabidiol Is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19
NPDI-Ujn_7A Cannabis (Cannabis sativa) Structural requirements for potent direct inhibition of human cytochrome P450 1A1 by cannabidiol: role of pentylresorcinol moiety.
NPDI-vhBMSw Cannabis (Cannabis sativa) Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse
NPDI-euNEwQ Cannabis (Cannabis sativa) Cannabidiol enhances xenobiotic permeability through the human placental barrier by direct inhibition of breast cancer resistance protein: an ex vivo study.
NPDI-l0yevQ Cannabis (Cannabis sativa) CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells
NPDI-vniY7Q Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity.
NPDI-gTt8Dw Cannabis (Cannabis sativa) Safety and pharmacokinetics of oral cannabidiol when administered concomitantly with intravenous fentanyl in humans
NPDI-Z6vbAA Cannabis (Cannabis sativa) Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol
NPDI-ieYYdA Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6.
NPDI-iHWMgQ Cannabis (Cannabis sativa) Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety.
NPDI-m-U3YQ Cannabis (Cannabis sativa) The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids.
NPDI-VYyv-A Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes
NPDI-UaGLOg Cannabis (Cannabis sativa) Characterization of P-glycoprotein Inhibition by Major Cannabinoids from Marijuana
NPDI-cM9pfg Cannabis (Cannabis sativa) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells.
NPDI-i4m0FA Cannabis (Cannabis sativa) Cannabis Characterization of Bulk Plant Material

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