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  • Cannabis (Cannabis sativa)

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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-RPqAvQ Cannabis (Cannabis sativa) Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes 6-alpha-OH-CBD-quinidine In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2D6
cannabidiol 6α-oh-cannabidiol quinidine
NPDI-otngFw Cannabis (Cannabis sativa) Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes 6-alpha-OH-CBD-ketoconazole In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
cannabidiol 6α-oh-cannabidiol ketoconazole
NPDI-AWv-_A Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) Valproic Acid Effect on CBD In Vivo Interaction positive — PK Interaction - Decreased systemic exposure
cannabidiol valproic acid
NPDI-4EVwQw Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) Clobazam Effect on CBD In Vivo Interaction negative — No Effect (based on bioequivalence limits)
cannabidiol clobazam
NPDI-tjxX2A Cannabis (Cannabis sativa) Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes 6-alpha-OH-CBD-sulfaphenazole In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2C9
cannabidiol 6α-oh-cannabidiol sulfaphenazole
NPDI-jJ11Ig Cannabis (Cannabis sativa) Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes 6-alpha-OH-CBD-omeprazole In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
cannabidiol 6α-oh-cannabidiol omeprazole
NPDI-2TMzVA Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) Stiripentol Effect on CBD, 6-OH-CBD, and 7-COOH-CBD In Vivo Interaction negative — No Effect (based on bioequivalence limits)
cannabidiol stiripentol
NPDI-6v65qQ Cannabis (Cannabis sativa) Pharmacological Effects of Cannabinoids on the Caco-2 Cell Culture Model of Intestinal Permeability CBD In Vitro Transporter Kinetics positive — In Vitro Transport
  • P-gp (ABCB1)
cannabidiol
NPDI-AEDMtg Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) Valproic Acid Effect on Cannabidiol Metabolites In Vivo Interaction negative — No Effect (based on bioequivalence limits)
cannabidiol valproic acid
NPDI-oZGcUg Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Inhibition of P-gp by Cannabidiol 25 µM In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
calcein-am cannabidiol
NPDI-IoxesQ Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Inhibition of P-gp by Cannabidiol 10 µM In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
calcein-am cannabidiol
NPDI-mLsAbQ Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Inhibition of P-gp by Cannabidiol 25 µM In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
rhodamine 123 cannabidiol
NPDI-cqaAMA Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Inhibition of P-gp by Cannabidiol 10µM In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
3,3′-diethyloxacarbocyanine iodide cannabidiol
NPDI-mbNW9A Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Induction of P-gp transporter (protein) by Cannabidiol In Vitro Transporter Induction positive — In Vitro Transporter Induction
  • P-gp (ABCB1)
cannabidiol
NPDI-DZj9Zg Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Down regulation of P-gp transporter (protein) by Cannabidiol In Vitro Transporter Induction positive — In Vitro Transporter Down Regulation
  • P-gp (ABCB1)
cannabidiol
NPDI-E7xthw Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Down regulation of P-gp (mRNA) by Cannabidiol In Vitro Transporter Induction positive — In Vitro Transporter Down Regulation
  • P-gp (ABCB1)
cannabidiol
NPDI-spUvqw Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Induction of BCRP transporter (mRNA) by Cannabidiol In Vitro Transporter Induction positive — In Vitro Transporter Induction
  • BCRP (ABCG2)
cannabidiol
NPDI-Aasqdw Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Induction of BCRP transporter (protein) by Cannabidiol In Vitro Transporter Induction positive — In Vitro Transporter Induction
  • BCRP (ABCG2)
cannabidiol
NPDI-Ix-KKg Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Induction of BCRP transporter (protein) by Cannabidiol In Vitro Transporter Induction positive — In Vitro Transporter Induction
  • BCRP (ABCG2)
cannabidiol
NPDI-Z_m2jA Cannabis (Cannabis sativa) Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19. Inhibition of CYP2C19 enzyme with Cannabidiol In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- cannabidiol
NPDI-29ER6A Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Down regulation of P-gp transporter (protein) by Cannabidiol In Vitro Transporter Induction positive — In Vitro Transporter Down Regulation
  • P-gp (ABCB1)
cannabidiol
NPDI-jHdxpA Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Induction (mRNA) of BCRP transporter with Cannabidiol In Vitro Transporter Induction positive — In Vitro Transporter Induction
  • BCRP (ABCG2)
cannabidiol
NPDI-PWUeog Cannabis (Cannabis sativa) Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1) Inhibition of ABCC1 by Cannabidiol In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • ABCC1
vincristine cannabidiol
NPDI-PaO28A Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Non-induction of BCRP transporter (protein) by Cannabiodiol In Vitro Transporter Induction negative — In Vitro Transporter Non-induction
  • BCRP (ABCG2)
cannabidiol
NPDI-olqNRw Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Induction of BCRP transporter (protein) by Cannabidiol In Vitro Transporter Induction positive — In Vitro Transporter Induction
  • BCRP (ABCG2)
cannabidiol
NPDI-2LIXDQ Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Down regulation of P-gp transporter (protein) by Cannabidiol In Vitro Transporter Induction positive — In Vitro Transporter Down Regulation
  • P-gp (ABCB1)
cannabidiol
NPDI-fw_WMw Cannabis (Cannabis sativa) Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19. Inhibition of CYP2C19 by Cannabidiol In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
omeprazole 5-hydroxyomeprazole cannabidiol
NPDI-9kN5_g Cannabis (Cannabis sativa) Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19. Inhibition of CYP2C19 by Cannabidiol In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- cannabidiol
NPDI-GEE68Q Cannabis (Cannabis sativa) Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19. Inhibition of CYP2C19 by Cannabidiol In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- cannabidiol
NPDI-kJ7mIQ Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) CBD effect on CLB and N-desmethylclobazam In Vivo Interaction positive — PK Interaction - Increased systemic exposure
clobazam cannabidiol
NPDI-Y9U8Tw Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) CBD Effect on clobazam and N-desmethylclobazam In Vivo Interaction negative — No Effect (based on bioequivalence limits)
clobazam cannabidiol
NPDI-wM7_CQ Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) CBD Effect on Valproic Acid Concentrations In Vivo Interaction negative — No Effect (based on bioequivalence limits)
valproic acid cannabidiol
NPDI-BfJ7dA Cannabis (Cannabis sativa) Structural requirements for potent direct inhibition of human cytochrome P450 1A1 by cannabidiol: role of pentylresorcinol moiety. Cannabidiol In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin cannabidiol
NPDI-8_xKYg Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) CBD Effect on Stiripentol Concentrations In Vivo Interaction positive — PK Interaction - Increased systemic exposure
stiripentol cannabidiol
NPDI-8jlF2g Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Recombinant: CBD-AMMC In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-methoxy-4-methylcoumarin 3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-hydroxy-4-methylcoumarin cannabidiol
NPDI-dh6TjQ Cannabis (Cannabis sativa) Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse CBD-UGT1A9 Inhibition In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A9
ethanol ethyl glucuronide cannabidiol
NPDI-Q2pa5g Cannabis (Cannabis sativa) CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells CBD In Vitro Transporter Induction positive — In Vitro Transporter Induction
  • P-gp (ABCB1)
cannabidiol
NPDI-dvyC1w Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. iHLMs: CBD-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin cannabidiol
NPDI-UlPhZQ Cannabis (Cannabis sativa) Safety and pharmacokinetics of oral cannabidiol when administered concomitantly with intravenous fentanyl in humans Plasma CBD Concentrations In Vivo Interaction negative — No Effect (based on bioequivalence limits)
fentanyl cannabidiol
NPDI-4htiMA Cannabis (Cannabis sativa) Cannabidiol enhances xenobiotic permeability through the human placental barrier by direct inhibition of breast cancer resistance protein: an ex vivo study. BeWo: CBD-mitoxantrone In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • BCRP (ABCG2)
mitoxantrone cannabidiol
NPDI-GRyerw Cannabis (Cannabis sativa) Cannabidiol enhances xenobiotic permeability through the human placental barrier by direct inhibition of breast cancer resistance protein: an ex vivo study. MCF7/P-gp: CBD-mitoxantrone In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
mitoxantrone cannabidiol
NPDI-b6F8pQ Cannabis (Cannabis sativa) Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol Cannabidiol In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin cannabidiol
NPDI-ILsKWw Cannabis (Cannabis sativa) Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse CBD on ethanol glucuronidation In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT
ethanol ethyl glucuronide cannabidiol
NPDI-DpYeow Cannabis (Cannabis sativa) Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse CBD-UGT2B7 Inhibition In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT2B7
ethanol ethyl glucuronide cannabidiol
NPDI-XouN0Q Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. pHLM: CBD-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin cannabidiol
NPDI-P2rdYg Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. rCYP2C9: CBD-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin cannabidiol
NPDI-Fqa3JA Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. iHLM: CBD-diclofenac In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac cannabidiol
NPDI-LKS7Ow Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. rCYP2C9: CBD-diclofenac In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac cannabidiol
NPDI-THQe_g Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Recombinant: CBD-dextromethorphan In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan cannabidiol
NPDI-ckGWRw Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. pHLM: CBD-dextromethorphan In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan cannabidiol
NPDI-FmAizA Cannabis (Cannabis sativa) Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. CYP3A4-CBD In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
diltiazem n-demethyldiltiazem cannabidiol
NPDI-zkYApA Cannabis (Cannabis sativa) Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. HLM-CBD In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
diltiazem n-demethyldiltiazem cannabidiol
NPDI-ZFfQJg Cannabis (Cannabis sativa) The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids. Mitoxantrone-CBD In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • BCRP (ABCG2)
mitoxantrone cannabidiol
NPDI-FompNA Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes 1A2: CBD In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A2
7-ethoxyresorufin resorufin cannabidiol
NPDI-jYDUsw Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes 1A1: CBD In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin cannabidiol
NPDI-bxWjqg Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes HLMs: CBD In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin cannabidiol
NPDI-pvvgAw Cannabis (Cannabis sativa) Characterization of P-glycoprotein Inhibition by Major Cannabinoids from Marijuana CBD-Rh123 (Flow-Cytometry Assay) In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
rhodamine 123 cannabidiol
NPDI-gOdMHw Cannabis (Cannabis sativa) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. CCRF-CEM: CBD In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • P-gp (ABCB1)
rhodamine 123 cannabidiol
NPDI-UIHjqQ Cannabis (Cannabis sativa) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. CEM/VLB100: CBD In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • P-gp (ABCB1)
rhodamine 123 cannabidiol
NPDI-_jX3DQ Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) CBD Effect on N-desmethylclobazam Concentrations In Vivo Interaction positive — PK Interaction - Increased systemic exposure
n-desmethylclobazam cannabidiol
NPDI-d2rDLg Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) CBD Effect on Midazolam In Vivo Interaction negative — No Effect (based on bioequivalence limits)
midazolam cannabidiol
NPDI-a3nUTg Cannabis (Cannabis sativa) In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites Inhibition of CES1 by CBD In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CES1
oseltamivir phosphate oseltamivir acid cannabidiol
NPDI-gAcr3g Cannabis (Cannabis sativa) In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites Evaluation of Time-Dependent CES1 Inhibition by CBD (0 min) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CES1
oseltamivir phosphate oseltamivir acid cannabidiol
NPDI-sciDeA Cannabis (Cannabis sativa) In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites Evaluation of Time-Dependent CES1 Inhibition by CBD (30 min) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CES1
oseltamivir phosphate oseltamivir acid cannabidiol
NPDI-4qS0VQ Cannabis (Cannabis sativa) Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells Induction of CYP1A1 mRNA expression by 50 µM cannabidiol In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP1A1
cannabidiol
NPDI-qeGJYg Cannabis (Cannabis sativa) Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1) Negligible inhibition of ABCC1 by Cannabidiol In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • ABCC1
fluo3 cannabidiol
NPDI-3VIAiw Cannabis (Cannabis sativa) Cannabidiol enhances xenobiotic permeability through the human placental barrier by direct inhibition of breast cancer resistance protein: an ex vivo study. Jar: CBD-Mitoxantrone In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • BCRP (ABCG2)
mitoxantrone cannabidiol
NPDI-soqMrQ Cannabis (Cannabis sativa) Cannabis Characterization of Bulk Plant Material Cannabis bulk plant Characterization of Material Characterization of Material
ID Subject of Study Name
NPDI-zlH6uA Cannabis (Cannabis sativa) Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes
NPDI-SiYA_A Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol)
NPDI-BvR0Pw Cannabis (Cannabis sativa) Pharmacological Effects of Cannabinoids on the Caco-2 Cell Culture Model of Intestinal Permeability
NPDI-1wiJBw Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines.
NPDI-9V_SXw Cannabis (Cannabis sativa) Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19.
NPDI-ahQtSQ Cannabis (Cannabis sativa) Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1)
NPDI-Ujn_7A Cannabis (Cannabis sativa) Structural requirements for potent direct inhibition of human cytochrome P450 1A1 by cannabidiol: role of pentylresorcinol moiety.
NPDI-ieYYdA Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6.
NPDI-vhBMSw Cannabis (Cannabis sativa) Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse
NPDI-l0yevQ Cannabis (Cannabis sativa) CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells
NPDI-vniY7Q Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity.
NPDI-gTt8Dw Cannabis (Cannabis sativa) Safety and pharmacokinetics of oral cannabidiol when administered concomitantly with intravenous fentanyl in humans
NPDI-euNEwQ Cannabis (Cannabis sativa) Cannabidiol enhances xenobiotic permeability through the human placental barrier by direct inhibition of breast cancer resistance protein: an ex vivo study.
NPDI-Z6vbAA Cannabis (Cannabis sativa) Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol
NPDI-iHWMgQ Cannabis (Cannabis sativa) Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety.
NPDI-m-U3YQ Cannabis (Cannabis sativa) The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids.
NPDI-VYyv-A Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes
NPDI-UaGLOg Cannabis (Cannabis sativa) Characterization of P-glycoprotein Inhibition by Major Cannabinoids from Marijuana
NPDI-cM9pfg Cannabis (Cannabis sativa) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells.
NPDI-d4aGfw Cannabis (Cannabis sativa) In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites
NPDI-lY9NZQ Cannabis (Cannabis sativa) Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells
NPDI-i4m0FA Cannabis (Cannabis sativa) Cannabis Characterization of Bulk Plant Material

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