ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-soqMrQ Cannabis (Cannabis sativa) Cannabis Characterization of Bulk Plant Material Cannabis bulk plant Characterization of Material Characterization of Material
NPDI-oZGcUg Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Inhibition of P-gp by Cannabidiol 25 µM In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
calcein-am cannabidiol
NPDI-IoxesQ Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Inhibition of P-gp by Cannabidiol 10 µM In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
calcein-am cannabidiol
NPDI-mLsAbQ Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Inhibition of P-gp by Cannabidiol 25 µM In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
rhodamine 123 cannabidiol
NPDI-cqaAMA Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Inhibition of P-gp by Cannabidiol 10µM In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
3,3′-diethyloxacarbocyanine iodide cannabidiol
NPDI-PaO28A Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Non-induction of BCRP transporter (protein) by Cannabiodiol In Vitro Transporter Induction negative — In Vitro Transporter Non-induction
  • BCRP (ABCG2)
cannabidiol
NPDI-P9f-Mw Cannabis (Cannabis sativa) Enhanced biotransformation of theophylline in marihuana and tobacco smokers. Decreased systemic exposure of Theophylline with Smoked Marihuana (non Tobacco smoker) In Vivo Interaction positive — PK Interaction - Increased systemic exposure
theophylline medicinal cannabis
NPDI-mbNW9A Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Induction of P-gp transporter (protein) by Cannabidiol In Vitro Transporter Induction positive — In Vitro Transporter Induction
  • P-gp (ABCB1)
cannabidiol
NPDI-DZj9Zg Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Down regulation of P-gp transporter (protein) by Cannabidiol In Vitro Transporter Induction positive — In Vitro Transporter Down Regulation
  • P-gp (ABCB1)
cannabidiol
NPDI-E7xthw Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Down regulation of P-gp (mRNA) by Cannabidiol In Vitro Transporter Induction positive — In Vitro Transporter Down Regulation
  • P-gp (ABCB1)
cannabidiol
NPDI-6t3-aw Cannabis (Cannabis sativa) Enhanced biotransformation of theophylline in marihuana and tobacco smokers. Decreased systemic exposure of Theophylline with Smoked Tobacco (no Marihuana smoker) In Vivo Interaction positive — PK Interaction - Decreased systemic exposure
theophylline medicinal cannabis
NPDI-spUvqw Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Induction of BCRP transporter (mRNA) by Cannabidiol In Vitro Transporter Induction positive — In Vitro Transporter Induction
  • BCRP (ABCG2)
cannabidiol
NPDI-Aasqdw Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Induction of BCRP transporter (protein) by Cannabidiol In Vitro Transporter Induction positive — In Vitro Transporter Induction
  • BCRP (ABCG2)
cannabidiol
NPDI-yqEgVA Cannabis (Cannabis sativa) Medicinal Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel Docetaxel PK ± medicinal cannabis In Vivo Interaction negative — No Effect (based on bioequivalence limits)
  • CYP3A
docetaxel medicinal cannabis
NPDI-Ix-KKg Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Induction of BCRP transporter (protein) by Cannabidiol In Vitro Transporter Induction positive — In Vitro Transporter Induction
  • BCRP (ABCG2)
cannabidiol
NPDI-Z_m2jA Cannabis (Cannabis sativa) Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19. Inhibition of CYP2C19 enzyme with Cannabidiol In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- cannabidiol
NPDI-29ER6A Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Down regulation of P-gp transporter (protein) by Cannabidiol In Vitro Transporter Induction positive — In Vitro Transporter Down Regulation
  • P-gp (ABCB1)
cannabidiol
NPDI-jHdxpA Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Induction (mRNA) of BCRP transporter with Cannabidiol In Vitro Transporter Induction positive — In Vitro Transporter Induction
  • BCRP (ABCG2)
cannabidiol
NPDI-PWUeog Cannabis (Cannabis sativa) Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1) Inhibition of ABCC1 by Cannabidiol In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • ABCC1
vincristine cannabidiol
NPDI-olqNRw Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Induction of BCRP transporter (protein) by Cannabidiol In Vitro Transporter Induction positive — In Vitro Transporter Induction
  • BCRP (ABCG2)
cannabidiol
NPDI-2LIXDQ Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. Down regulation of P-gp transporter (protein) by Cannabidiol In Vitro Transporter Induction positive — In Vitro Transporter Down Regulation
  • P-gp (ABCB1)
cannabidiol
NPDI-7RWWrg Cannabis (Cannabis sativa) Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1) Inhibition of ABCC1 by Cannabinol In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • ABCC1
vincristine cannabinol
NPDI-fw_WMw Cannabis (Cannabis sativa) Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19. Inhibition of CYP2C19 by Cannabidiol In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
omeprazole 5-hydroxyomeprazole cannabidiol
NPDI-9kN5_g Cannabis (Cannabis sativa) Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19. Inhibition of CYP2C19 by Cannabidiol In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- cannabidiol
NPDI-RUuAkA Cannabis (Cannabis sativa) Enhanced biotransformation of theophylline in marihuana and tobacco smokers. Decreased systemic exposure of Theophylline with Smoked Marihuana (Tobacco smoker) In Vivo Interaction positive — PK Interaction - Decreased systemic exposure
theophylline medicinal cannabis
NPDI-GEE68Q Cannabis (Cannabis sativa) Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19. Inhibition of CYP2C19 by Cannabidiol In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- cannabidiol
NPDI-lNsNoQ Cannabis (Cannabis sativa) Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1) Negligible inhibition of ABCC1 by THC In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • ABCC1
fluo3 delta-9-tetrahydrocannabinol
NPDI-z3MwKw Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) Clobazam Effect on 6-OH-CBD In Vivo Interaction negative — No Effect (based on bioequivalence limits)
6α-oh-cannabidiol clobazam
NPDI-PxRYvA Cannabis (Cannabis sativa) Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids CBN-UGT1A10 In Vitro Enzyme Kinetics positive — In Vitro Detectable Kinetic Metabolism
  • UGT1A10
cannabinol 11-hydroxycannabinol
NPDI-ZNPhvw Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. iHLM: CBN-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin cannabinol
NPDI-wx2mcg Cannabis (Cannabis sativa) A phase I study to assess the effect of food on the single dose bioavailability of the THC/CBD oromucosal spray Plasma Concentration of CBD when Fed In Vivo Pharmacokinetics
NPDI-qk8qvw Cannabis (Cannabis sativa) Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids THC-OH-UGT1A9 In Vitro Enzyme Kinetics positive — In Vitro Detectable Kinetic Metabolism
  • UGT1A9
11-hydroxy-delta-9-tetrahydrocannabinol 11-nor-9-carboxy-delta9-tetrahydrocannabinol
NPDI-4tAywg Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes 1A1: THC In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin delta-9-tetrahydrocannabinol
NPDI-kJ7mIQ Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) CBD effect on CLB and N-desmethylclobazam In Vivo Interaction positive — PK Interaction - Increased systemic exposure
clobazam cannabidiol
NPDI-Y9U8Tw Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) CBD Effect on clobazam and N-desmethylclobazam In Vivo Interaction negative — No Effect (based on bioequivalence limits)
clobazam cannabidiol
NPDI-wM7_CQ Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) CBD Effect on Valproic Acid Concentrations In Vivo Interaction negative — No Effect (based on bioequivalence limits)
valproic acid cannabidiol
NPDI-BfJ7dA Cannabis (Cannabis sativa) Structural requirements for potent direct inhibition of human cytochrome P450 1A1 by cannabidiol: role of pentylresorcinol moiety. Cannabidiol In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin cannabidiol
NPDI-iJRQWg Cannabis (Cannabis sativa) Structural requirements for potent direct inhibition of human cytochrome P450 1A1 by cannabidiol: role of pentylresorcinol moiety. THC In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin delta-9-tetrahydrocannabinol
NPDI-jwN2Vw Cannabis (Cannabis sativa) Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse CBN-UGT1A9 Inhibition In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A9
ethanol ethyl glucuronide cannabinol
NPDI-8_xKYg Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) CBD Effect on Stiripentol Concentrations In Vivo Interaction positive — PK Interaction - Increased systemic exposure
stiripentol cannabidiol
NPDI-PwGUoQ Cannabis (Cannabis sativa) Interaction between Marihuana and Ethanol: Effects on Psychomotor Performance Mean THC Concentration with Placebo In Vivo Interaction negative — No Effect (based on bioequivalence limits)
delta-9-tetrahydrocannabinol placebo
NPDI-8jlF2g Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Recombinant: CBD-AMMC In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-methoxy-4-methylcoumarin 3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-hydroxy-4-methylcoumarin cannabidiol
NPDI-GT0H0Q Cannabis (Cannabis sativa) Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids THC-COOH-UGT1A1 In Vitro Enzyme Kinetics positive — In Vitro Detectable Kinetic Metabolism
  • UGT1A1
11-nor-9-carboxy-delta9-tetrahydrocannabinol glucuronide
NPDI-RPqAvQ Cannabis (Cannabis sativa) Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes 6-alpha-OH-CBD-quinidine In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2D6
cannabidiol 6α-oh-cannabidiol quinidine
NPDI-0g58zw Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Recombinant: CBN-dextromethorphan In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan cannabinol
NPDI-Qoqt5Q Cannabis (Cannabis sativa) Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids CBN-UGT1A7 In Vitro Enzyme Kinetics positive — In Vitro Detectable Kinetic Metabolism
  • UGT1A7
cannabinol 11-hydroxycannabinol
NPDI-p2jqFw Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. pHLM: CBN-dextromethorphan In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan cannabinol
NPDI-xU8LWA Cannabis (Cannabis sativa) Does olanzapine inhibit the psychomimetic effects of Δ9-tetrahydrocannabinol? THC PK In Vivo Pharmacokinetics
NPDI-GNkg_Q Cannabis (Cannabis sativa) Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids THC-COOH-UGT1A3 In Vitro Enzyme Kinetics positive — In Vitro Detectable Kinetic Metabolism
  • UGT1A3
11-nor-9-carboxy-delta9-tetrahydrocannabinol glucuronide
NPDI-9ju4Lw Cannabis (Cannabis sativa) Structural requirements for potent direct inhibition of human cytochrome P450 1A1 by cannabidiol: role of pentylresorcinol moiety. Cannabidiol-2',6'-dimethyl ether In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin cannabidiol-dimethyl ether
NPDI-CWIhCg Cannabis (Cannabis sativa) Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids THC-OH-UGT1A10 In Vitro Enzyme Kinetics positive — In Vitro Detectable Kinetic Metabolism
  • UGT1A10
11-hydroxy-delta-9-tetrahydrocannabinol 11-nor-9-carboxy-delta9-tetrahydrocannabinol
NPDI-otngFw Cannabis (Cannabis sativa) Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes 6-alpha-OH-CBD-ketoconazole In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
cannabidiol 6α-oh-cannabidiol ketoconazole
NPDI-7hkXUg Cannabis (Cannabis sativa) Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse CBN on ethanol glucuronidation In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • UGT
cannabinol
NPDI-dh6TjQ Cannabis (Cannabis sativa) Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse CBD-UGT1A9 Inhibition In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A9
ethanol ethyl glucuronide cannabidiol
NPDI-px3AyQ Cannabis (Cannabis sativa) A phase I study to assess the effect of food on the single dose bioavailability of the THC/CBD oromucosal spray Plasma Concentration of THC when Fed In Vivo Pharmacokinetics
NPDI-hnUjdg Cannabis (Cannabis sativa) A phase I study to assess the effect of food on the single dose bioavailability of the THC/CBD oromucosal spray Plasma Concentration of CBD when Fasting In Vivo Pharmacokinetics
NPDI-csAo1g Cannabis (Cannabis sativa) A phase I study to assess the effect of food on the single dose bioavailability of the THC/CBD oromucosal spray Plasma Concentration of 11-OH-THC when Fasting In Vivo Pharmacokinetics
NPDI-I4ebig Cannabis (Cannabis sativa) A phase I study to assess the effect of food on the single dose bioavailability of the THC/CBD oromucosal spray Plasma Concentration of THC when Fasting In Vivo Pharmacokinetics
NPDI-37uQKw Cannabis (Cannabis sativa) A phase I study to assess the effect of food on the single dose bioavailability of the THC/CBD oromucosal spray Plasma Concentration of 11-OH-THC when Fed In Vivo Pharmacokinetics
NPDI-a65Zxg Cannabis (Cannabis sativa) Interaction between Marihuana and Ethanol: Effects on Psychomotor Performance Mean THC Plasma Concentration with High Ethanol In Vivo Interaction negative — No Effect (based on bioequivalence limits)
delta-9-tetrahydrocannabinol ethanol
NPDI-tUG7XA Cannabis (Cannabis sativa) Influence of cannabidiol on secobarbital effects and plasma kinetics Plasma Concentrations of Secobarbital After Placebo Pretreatment and Oral Administration of Secobarbital In Vivo Interaction negative — No Effect (based on bioequivalence limits)
secobarbital placebo
NPDI-noOe3w Cannabis (Cannabis sativa) Influence of cannabidiol on secobarbital effects and plasma kinetics Secobarbital Plasma Concentrations Following Sodium Secobarbital Ingestion and 150 µg/kg CBD Pretreatment In Vivo Interaction negative — No Effect (based on bioequivalence limits)
secobarbital delta-9-tetrahydrocannabinol
NPDI-SCT2WA Cannabis (Cannabis sativa) Influence of cannabidiol on secobarbital effects and plasma kinetics Secobarbital Plasma Concentrations Following Sodium Secobarbital Ingestion and 500 µg/kg CBD Pretreatment In Vivo Interaction negative — No Effect (based on bioequivalence limits)
secobarbital delta-9-tetrahydrocannabinol
NPDI-Q2pa5g Cannabis (Cannabis sativa) CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells CBD In Vitro Transporter Induction positive — In Vitro Transporter Induction
  • P-gp (ABCB1)
cannabidiol
NPDI-ypo3GA Cannabis (Cannabis sativa) Interaction between Marihuana and Ethanol: Effects on Psychomotor Performance Mean THC Plasma Concentration with High Ethanol In Vivo Interaction negative — No Effect (based on bioequivalence limits)
delta-9-tetrahydrocannabinol ethanol
NPDI-E6xHTA Cannabis (Cannabis sativa) Structural requirements for potent direct inhibition of human cytochrome P450 1A1 by cannabidiol: role of pentylresorcinol moiety. Cannabidiol-2'-monomethyl ether In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin cannabidiol-2'-monomethyl ether
NPDI-JvqWDQ Cannabis (Cannabis sativa) Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse CBN-UGT2B7 Induction In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • UGT2B7
cannabinol
NPDI-dvyC1w Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. iHLMs: CBD-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin cannabidiol
NPDI-UlPhZQ Cannabis (Cannabis sativa) Safety and pharmacokinetics of oral cannabidiol when administered concomitantly with intravenous fentanyl in humans Plasma CBD Concentrations In Vivo Interaction negative — No Effect (based on bioequivalence limits)
fentanyl cannabidiol
NPDI-4htiMA Cannabis (Cannabis sativa) Cannabidiol enhances xenobiotic permeability through the human placental barrier by direct inhibition of breast cancer resistance protein: an ex vivo study. BeWo: CBD-mitoxantrone In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • BCRP (ABCG2)
mitoxantrone cannabidiol
NPDI-GRyerw Cannabis (Cannabis sativa) Cannabidiol enhances xenobiotic permeability through the human placental barrier by direct inhibition of breast cancer resistance protein: an ex vivo study. MCF7/P-gp: CBD-mitoxantrone In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
mitoxantrone cannabidiol
NPDI-b6F8pQ Cannabis (Cannabis sativa) Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol Cannabidiol In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin cannabidiol
NPDI-pQrX0g Cannabis (Cannabis sativa) Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol CBD-dimethyl ether In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin cannabidiol-dimethyl ether
NPDI-ZmjyHw Cannabis (Cannabis sativa) Structural requirements for potent direct inhibition of human cytochrome P450 1A1 by cannabidiol: role of pentylresorcinol moiety. Cannabidvarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin cannabidivarin
NPDI-ILsKWw Cannabis (Cannabis sativa) Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse CBD on ethanol glucuronidation In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT
ethanol ethyl glucuronide cannabidiol
NPDI-4ZUTtw Cannabis (Cannabis sativa) Medicinal Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel Irinotecan PK ± medicinal cannabis In Vivo Interaction negative — No Effect (based on bioequivalence limits)
  • CYP3A
irinotecan medicinal cannabis
NPDI-AWv-_A Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) Valproic Acid Effect on CBD In Vivo Interaction positive — PK Interaction - Decreased systemic exposure
cannabidiol valproic acid
NPDI-DpYeow Cannabis (Cannabis sativa) Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse CBD-UGT2B7 Inhibition In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT2B7
ethanol ethyl glucuronide cannabidiol
NPDI-XouN0Q Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. pHLM: CBD-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin cannabidiol
NPDI-zu7hCg Cannabis (Cannabis sativa) CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells THC In Vitro Transporter Induction positive — In Vitro Transporter Induction
  • P-gp (ABCB1)
delta-9-tetrahydrocannabinol
NPDI-4EVwQw Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) Clobazam Effect on CBD In Vivo Interaction negative — No Effect (based on bioequivalence limits)
cannabidiol clobazam
NPDI-jZO6oQ Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. pHLM: THC-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin delta-9-tetrahydrocannabinol
NPDI-mGu2ew Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. pHLM: CBN-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin cannabinol
NPDI-vUechg Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. iHLM: THC-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin delta-9-tetrahydrocannabinol
NPDI-Jb4JFA Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. iHLM: THC-diclofenac In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac delta-9-tetrahydrocannabinol
NPDI-y29wsw Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Recombinant: CBDM-AMMC In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2D6
3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-methoxy-4-methylcoumarin 3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-hydroxy-4-methylcoumarin cannabidiol-dimethyl ether
NPDI-qhVkgQ Cannabis (Cannabis sativa) The effects of cannabinoids on the pharmacokinetics of indinavir and nelfinavir IDV+THC PK at Baseline and Day 14 In Vivo Interaction negative — No Effect (based on bioequivalence limits)
indinavir delta-9-tetrahydrocannabinol
NPDI-J5A-Vg Cannabis (Cannabis sativa) The effects of cannabinoids on the pharmacokinetics of indinavir and nelfinavir NFV+THC PK at Baseline and Day 14 In Vivo Interaction negative — No Effect (based on bioequivalence limits)
nelfinavir delta-9-tetrahydrocannabinol
NPDI-R1QKZg Cannabis (Cannabis sativa) Pharmacological Effects of Cannabinoids on the Caco-2 Cell Culture Model of Intestinal Permeability THC In Vitro Transporter Kinetics positive — In Vitro Transport
  • P-gp (ABCB1)
delta-9-tetrahydrocannabinol
NPDI-Rsay5Q Cannabis (Cannabis sativa) Interaction between naltrexone and oral THC in heavy marijuana smokers Effect of naltrexone on THC concentration In Vivo Interaction negative — No Effect (based on bioequivalence limits)
delta-9-tetrahydrocannabinol naltrexone
NPDI-9oyo4g Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) Clobazam Effect on 7-OH-CBD In Vivo Interaction negative — No Effect (based on bioequivalence limits)
7-hydroxycannabidiol clobazam
NPDI-ckGWRw Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. pHLM: CBD-dextromethorphan In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan cannabidiol
NPDI-DqfMEw Cannabis (Cannabis sativa) Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol Cannbidiol-2'-monomethyl ether In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin cannabidiol-2'-monomethyl ether
NPDI-wnmeug Cannabis (Cannabis sativa) Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol Cannabidivarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin cannabidivarin
NPDI-ToTRjw Cannabis (Cannabis sativa) Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids CBN-UGT1A8 In Vitro Enzyme Kinetics positive — In Vitro Detectable Kinetic Metabolism
  • UGT1A8
cannabinol 11-hydroxycannabinol
NPDI-akOrWg Cannabis (Cannabis sativa) Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids CBN-UGT1A9 In Vitro Enzyme Kinetics positive — In Vitro Detectable Kinetic Metabolism
  • UGT1A9
cannabinol 11-hydroxycannabinol
NPDI-tjxX2A Cannabis (Cannabis sativa) Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes 6-alpha-OH-CBD-sulfaphenazole In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2C9
cannabidiol 6α-oh-cannabidiol sulfaphenazole
NPDI-jJ11Ig Cannabis (Cannabis sativa) Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes 6-alpha-OH-CBD-omeprazole In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
cannabidiol 6α-oh-cannabidiol omeprazole
NPDI-ZM5Pkw Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) Clobazam Effect on 7-COOH-CBD In Vivo Interaction negative — No Effect (based on bioequivalence limits)
7-cooh-cbd clobazam
NPDI-P2rdYg Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. rCYP2C9: CBD-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin cannabidiol
NPDI-59dZ4A Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. rCYP2C9: THC-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin delta-9-tetrahydrocannabinol
NPDI-wt2yDg Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. rCYP2C9: CBN-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin cannabinol
NPDI-Fqa3JA Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. iHLM: CBD-diclofenac In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac cannabidiol
NPDI-V1SemA Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. iHLM: CBN-diclofenac In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac cannabinol
NPDI-bM6NOQ Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. rCYP2C9: THC-diclofenac In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac delta-9-tetrahydrocannabinol
NPDI-LKS7Ow Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. rCYP2C9: CBD-diclofenac In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac cannabidiol
NPDI-KqafWg Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. rCYP2C9: CBN-diclofenac In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac cannabinol
NPDI-THQe_g Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Recombinant: CBD-dextromethorphan In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan cannabidiol
NPDI-XBXjow Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Recombinant: THC-AMMC In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-methoxy-4-methylcoumarin 3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-hydroxy-4-methylcoumarin delta-9-tetrahydrocannabinol
NPDI-Hsp-vg Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Recombinant: THC-dextramethorphan In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan delta-9-tetrahydrocannabinol
NPDI-KQoVKg Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. HLMs: THC-dextromethorphan In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan delta-9-tetrahydrocannabinol
NPDI-b-kubA Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Recombinant: CBN-AMMC In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-methoxy-4-methylcoumarin 3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-hydroxy-4-methylcoumarin cannabinol
NPDI-iDzluw Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Recombinant: CBDV-AMMC In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-methoxy-4-methylcoumarin 3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-hydroxy-4-methylcoumarin cannabidivarin
NPDI-F3DjaQ Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Recombinant: CBDD-AMMC In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2D6
3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-methoxy-4-methylcoumarin 3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-hydroxy-4-methylcoumarin cannabidiol-dimethyl ether
NPDI-8vislA Cannabis (Cannabis sativa) Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. CYP3A4-THC In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A4
diltiazem n-demethyldiltiazem delta-9-tetrahydrocannabinol
NPDI-FmAizA Cannabis (Cannabis sativa) Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. CYP3A4-CBD In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
diltiazem n-demethyldiltiazem cannabidiol
NPDI-ens_Gw Cannabis (Cannabis sativa) Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. CYP3A4-CBN In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A4
diltiazem n-demethyldiltiazem cannabinol
NPDI-PS8_LQ Cannabis (Cannabis sativa) Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. HLM-THC In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A
diltiazem n-demethyldiltiazem delta-9-tetrahydrocannabinol
NPDI-zkYApA Cannabis (Cannabis sativa) Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. HLM-CBD In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
diltiazem n-demethyldiltiazem cannabidiol
NPDI-yszOMw Cannabis (Cannabis sativa) Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. HLM-CBN In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A
diltiazem n-demethyldiltiazem cannabinol
NPDI-2TMzVA Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) Stiripentol Effect on CBD, 6-OH-CBD, and 7-COOH-CBD In Vivo Interaction negative — No Effect (based on bioequivalence limits)
cannabidiol stiripentol
NPDI-dsHL7w Cannabis (Cannabis sativa) The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids. Mitoxantrone-CBN In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • BCRP (ABCG2)
mitoxantrone cannabinol
NPDI-ZFfQJg Cannabis (Cannabis sativa) The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids. Mitoxantrone-CBD In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • BCRP (ABCG2)
mitoxantrone cannabidiol
NPDI-LCPweA Cannabis (Cannabis sativa) Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). Calcein-AM-THC In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
calcein-am delta-9-tetrahydrocannabinol
NPDI-S4_OQA Cannabis (Cannabis sativa) Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). Rh-123-THC In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
rhodamine 123 delta-9-tetrahydrocannabinol
NPDI-3LZeDA Cannabis (Cannabis sativa) The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids. Mitoxantrone-THC In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • BCRP (ABCG2)
mitoxantrone delta-9-tetrahydrocannabinol
NPDI-FompNA Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes 1A2: CBD In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A2
7-ethoxyresorufin resorufin cannabidiol
NPDI-jYDUsw Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes 1A1: CBD In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin cannabidiol
NPDI-v65nxg Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes 1A1: CBN In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin cannabinol
NPDI-F-0XWg Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes 1A2: THC In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A2
7-ethoxyresorufin resorufin delta-9-tetrahydrocannabinol
NPDI-RC8Kxw Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes 1A2: CBN In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A2
7-ethoxyresorufin resorufin cannabinol
NPDI-DQGnJw Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes HLMs: THC In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin delta-9-tetrahydrocannabinol
NPDI-bxWjqg Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes HLMs: CBD In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin cannabidiol
NPDI-XKoD2A Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes HLMs: CBN In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin cannabinol
NPDI-pvvgAw Cannabis (Cannabis sativa) Characterization of P-glycoprotein Inhibition by Major Cannabinoids from Marijuana CBD-Rh123 (Flow-Cytometry Assay) In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
rhodamine 123 cannabidiol
NPDI-6v65qQ Cannabis (Cannabis sativa) Pharmacological Effects of Cannabinoids on the Caco-2 Cell Culture Model of Intestinal Permeability CBD In Vitro Transporter Kinetics positive — In Vitro Transport
  • P-gp (ABCB1)
cannabidiol
NPDI-G8_czw Cannabis (Cannabis sativa) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. CEM/VLB100: CBN In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • P-gp (ABCB1)
rhodamine 123 cannabinol
NPDI-EqzxjQ Cannabis (Cannabis sativa) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. CCRF-CEM: CBN In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • P-gp (ABCB1)
rhodamine 123 cannabinol
NPDI-gOdMHw Cannabis (Cannabis sativa) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. CCRF-CEM: CBD In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • P-gp (ABCB1)
rhodamine 123 cannabidiol
NPDI-8Ej-Bg Cannabis (Cannabis sativa) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. CCRF-CEM: THC In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • P-gp (ABCB1)
rhodamine 123 delta-9-tetrahydrocannabinol
NPDI-UIHjqQ Cannabis (Cannabis sativa) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. CEM/VLB100: CBD In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • P-gp (ABCB1)
rhodamine 123 cannabidiol
NPDI-NC4pjQ Cannabis (Cannabis sativa) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. CEM/VLB100: THC In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • P-gp (ABCB1)
rhodamine 123 delta-9-tetrahydrocannabinol
NPDI-a9Sh7Q Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) Stiripentol Effect on 7-OH-CBD In Vivo Interaction positive — PK Interaction - Decreased systemic exposure
7-hydroxycannabidiol stiripentol
NPDI-LI0O-A Cannabis (Cannabis sativa) In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites Inhibition of CES1 by CBN In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CES1
oseltamivir phosphate oseltamivir acid cannabinol
NPDI-AEDMtg Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) Valproic Acid Effect on Cannabidiol Metabolites In Vivo Interaction negative — No Effect (based on bioequivalence limits)
cannabidiol valproic acid
NPDI-_jX3DQ Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) CBD Effect on N-desmethylclobazam Concentrations In Vivo Interaction positive — PK Interaction - Increased systemic exposure
n-desmethylclobazam cannabidiol
NPDI-d2rDLg Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) CBD Effect on Midazolam In Vivo Interaction negative — No Effect (based on bioequivalence limits)
midazolam cannabidiol
NPDI-a3nUTg Cannabis (Cannabis sativa) In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites Inhibition of CES1 by CBD In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CES1
oseltamivir phosphate oseltamivir acid cannabidiol
NPDI--0E9EQ Cannabis (Cannabis sativa) In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites Evaluation of Time-Dependent CES1 Inhibition by CBN (30 min) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CES1
oseltamivir phosphate oseltamivir acid cannabinol
NPDI-qHswZw Cannabis (Cannabis sativa) Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells Induction of CYP1A1 mRNA expression by 50 µM delta-9-THC In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP1A1
delta-9-tetrahydrocannabinol
NPDI-M13k5Q Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Inhibition of 7-alpha-hydroxylation of delta-8-THC by ketoconazole In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
delta-8-tetrahydrocannabinol 7-alpha-hydroxy-delta-8-tetrahydrocannabinol ketoconazole
NPDI-rbqhsA Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Inhibition of 8-beta-hydroxylation of delta-9-THC by ketoconazole In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
delta-9-tetrahydrocannabinol 8-beta-hydroxy-delta-9-tetrahydrocannabinol ketoconazole
NPDI-abEayg Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Weak Inhibition of 11-hydroxylation of delta-9-THC by ketoconazole In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A
delta-9-tetrahydrocannabinol 11-hydroxy-delta-9-tetrahydrocannabinol ketoconazole
NPDI-M8-Oxw Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Weak Inhibition of 11-hydroxylation of delta-8-THC by ketoconazole In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A
delta-8-tetrahydrocannabinol 11-hydroxy-delta-8-tetrahydrocannabinol ketoconazole
NPDI-THVK4A Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes No inhibition of 8-beta-hydroxylation of delta-9-THC by 7,8-benzoflavone In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP1A
delta-9-tetrahydrocannabinol 8-beta-hydroxy-delta-9-tetrahydrocannabinol alpha-naphthoflavone
NPDI-I4dv_g Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Inhibition of 8-hydroxylation of cannabinol by ketoconazole In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
cannabinol 8-hydroxycannabinol ketoconazole
NPDI-VpD-Xg Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Weak Inhibition of 11-hydroxylation of cannabinol by ketoconazole In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A
cannabinol 11-hydroxycannabinol ketoconazole
NPDI-5Fz7kg Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Weak Inhibition of 7-alpha-hydroxylation of delta-8-THC by sulfaphenazole In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2C
delta-8-tetrahydrocannabinol 7-alpha-hydroxy-delta-8-tetrahydrocannabinol sulfaphenazole
NPDI-42-g8Q Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Inhibition of 11-hydroxylation of delta-8-THC by sulfaphenazole In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C
delta-8-tetrahydrocannabinol 11-hydroxy-delta-8-tetrahydrocannabinol sulfaphenazole
NPDI-Yr3jng Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Weak Inhibition of 8-beta-hydroxylation of delta-9-THC by sulfaphenazole In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2C
delta-9-tetrahydrocannabinol 8-beta-hydroxy-delta-9-tetrahydrocannabinol sulfaphenazole
NPDI-qmmKqA Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Inhibition of 11-hydroxylation of delta-9-THC by sulfaphenazole In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C
delta-9-tetrahydrocannabinol 11-hydroxy-delta-9-tetrahydrocannabinol sulfaphenazole
NPDI-uxfWFg Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Weak Inhibition of 8-hydroxylation of cannabinol by sulfaphenazole In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2C
cannabinol 8-hydroxycannabinol sulfaphenazole
NPDI-8flCOQ Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Inhibition of 11-hydroxylation of cannabinol by sulfaphenazole In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C
cannabinol 11-hydroxycannabinol sulfaphenazole
NPDI-RCBEtw Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Weak Inhibition of 11-hydroxylation of delta-8-THC by 7,8-benzoflavone In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP1A
delta-8-tetrahydrocannabinol 11-hydroxy-delta-8-tetrahydrocannabinol alpha-naphthoflavone
NPDI-IQtjvw Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Weak Inhibition of 11-hydroxylation of delta-9-THC by 7,8-benzoflavone In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP1A
delta-9-tetrahydrocannabinol 11-hydroxy-delta-9-tetrahydrocannabinol alpha-naphthoflavone
NPDI-jW07Iw Cannabis (Cannabis sativa) Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells Non-induction of CYP1A1 mRNA expression by 50 µM cannabinol In Vitro Enzyme Induction negative — In Vitro Enzyme Non-induction
  • CYP1A1
cannabinol
NPDI-EYnQkA Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes No inhibition of 7-alpha-hydroxylation of delta-8-THC by 7,8-benzoflavone In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP1A
delta-8-tetrahydrocannabinol 7-alpha-hydroxy-delta-8-tetrahydrocannabinol alpha-naphthoflavone
NPDI-YQ1c2Q Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Weak Inhibition of 11-hydroxylation of cannabinol by 7,8-benzoflavone In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP1A
cannabinol 11-hydroxycannabinol alpha-naphthoflavone
NPDI-gAcr3g Cannabis (Cannabis sativa) In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites Evaluation of Time-Dependent CES1 Inhibition by CBD (0 min) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CES1
oseltamivir phosphate oseltamivir acid cannabidiol
NPDI-t5Bygg Cannabis (Cannabis sativa) In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites Evaluation of Time-Dependent CES1 Inhibition by THC (0 min) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CES1
oseltamivir phosphate oseltamivir acid delta-9-tetrahydrocannabinol
NPDI-8d0Lug Cannabis (Cannabis sativa) In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites Evaluation of Time-Dependent CES1 Inhibition by THC (30 min) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CES1
oseltamivir phosphate oseltamivir acid delta-9-tetrahydrocannabinol
NPDI-sciDeA Cannabis (Cannabis sativa) In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites Evaluation of Time-Dependent CES1 Inhibition by CBD (30 min) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CES1
oseltamivir phosphate oseltamivir acid cannabidiol
NPDI-2KocMg Cannabis (Cannabis sativa) In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites Evaluation of Time-Dependent CES1 Inhibition by CBN (0 min) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CES1
oseltamivir phosphate oseltamivir acid cannabinol
NPDI-AIeEmg Cannabis (Cannabis sativa) In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites Inhibition of CES1 by THC In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CES1
oseltamivir phosphate oseltamivir acid delta-9-tetrahydrocannabinol
NPDI-v8ghug Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes No Inhibition of 8-hydroxylation of cannabinol by 7,8-benzoflavone In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP1A
cannabinol 8-hydroxycannabinol alpha-naphthoflavone
NPDI-4qS0VQ Cannabis (Cannabis sativa) Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells Induction of CYP1A1 mRNA expression by 50 µM cannabidiol In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP1A1
cannabidiol
NPDI-qeGJYg Cannabis (Cannabis sativa) Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1) Negligible inhibition of ABCC1 by Cannabidiol In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • ABCC1
fluo3 cannabidiol
NPDI-JnMHww Cannabis (Cannabis sativa) Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1) Negligible inhibition of ABCC1 by Cannabinol In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • ABCC1
fluo3 cannabinol
NPDI-uUyadQ Cannabis (Cannabis sativa) Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1) Negligible inhibition of ABCC1 by THC In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • ABCC1
vincristine delta-9-tetrahydrocannabinol
NPDI-3VIAiw Cannabis (Cannabis sativa) Cannabidiol enhances xenobiotic permeability through the human placental barrier by direct inhibition of breast cancer resistance protein: an ex vivo study. Jar: CBD-Mitoxantrone In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • BCRP (ABCG2)
mitoxantrone cannabidiol
ID Subject of Study Name
NPDI-1wiJBw Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines.
NPDI-9V_SXw Cannabis (Cannabis sativa) Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19.
NPDI-uPn_2w Cannabis (Cannabis sativa) Enhanced biotransformation of theophylline in marihuana and tobacco smokers.
NPDI-Rvn9SQ Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes
NPDI-lY9NZQ Cannabis (Cannabis sativa) Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells
NPDI-d4aGfw Cannabis (Cannabis sativa) In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites
NPDI-FhBdoQ Cannabis (Cannabis sativa) Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2).
NPDI-vhBMSw Cannabis (Cannabis sativa) Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse
NPDI-l0yevQ Cannabis (Cannabis sativa) CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells
NPDI-iHWMgQ Cannabis (Cannabis sativa) Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety.
NPDI-Asg_wA Cannabis (Cannabis sativa) Does olanzapine inhibit the psychomimetic effects of Δ9-tetrahydrocannabinol?
NPDI-vniY7Q Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity.
NPDI-UaGLOg Cannabis (Cannabis sativa) Characterization of P-glycoprotein Inhibition by Major Cannabinoids from Marijuana
NPDI-Ujn_7A Cannabis (Cannabis sativa) Structural requirements for potent direct inhibition of human cytochrome P450 1A1 by cannabidiol: role of pentylresorcinol moiety.
NPDI-euNEwQ Cannabis (Cannabis sativa) Cannabidiol enhances xenobiotic permeability through the human placental barrier by direct inhibition of breast cancer resistance protein: an ex vivo study.
NPDI-ieYYdA Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6.
NPDI-Z6vbAA Cannabis (Cannabis sativa) Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol
NPDI-zlH6uA Cannabis (Cannabis sativa) Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes
NPDI-BvR0Pw Cannabis (Cannabis sativa) Pharmacological Effects of Cannabinoids on the Caco-2 Cell Culture Model of Intestinal Permeability
NPDI-sUzV-g Cannabis (Cannabis sativa) Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
NPDI-cM9pfg Cannabis (Cannabis sativa) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells.
NPDI-VYyv-A Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes
NPDI-EngCtg Cannabis (Cannabis sativa) Medicinal Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel
NPDI-8lgFiA Cannabis (Cannabis sativa) Interaction between Marihuana and Ethanol: Effects on Psychomotor Performance
NPDI-xYeUJQ Cannabis (Cannabis sativa) Influence of cannabidiol on secobarbital effects and plasma kinetics
NPDI-ZqVOgw Cannabis (Cannabis sativa) Interaction between naltrexone and oral THC in heavy marijuana smokers
NPDI-qOTUkQ Cannabis (Cannabis sativa) The effects of cannabinoids on the pharmacokinetics of indinavir and nelfinavir
NPDI-gTt8Dw Cannabis (Cannabis sativa) Safety and pharmacokinetics of oral cannabidiol when administered concomitantly with intravenous fentanyl in humans
NPDI-UXOaUA Cannabis (Cannabis sativa) A phase I study to assess the effect of food on the single dose bioavailability of the THC/CBD oromucosal spray
NPDI-m-U3YQ Cannabis (Cannabis sativa) The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids.
NPDI-i4m0FA Cannabis (Cannabis sativa) Cannabis Characterization of Bulk Plant Material
NPDI-SiYA_A Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol)
NPDI-ahQtSQ Cannabis (Cannabis sativa) Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1)