In Vitro Enzyme Inhibition Experiment

Inhibition of CYP2C19 by Licochalcone A

Inhibition was detected.  Cutoff used —

50 % inhibition

mephenytoin, (s)-

licochalcone a

4-hydroxymephenytoin, (s)-

  • CYP2C19 4311137

Cell fraction Pooled human liver microsomes -7999662


Results come from both Table 1 and Figure 3

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

0.2 mg/mL

10 min


50 µM

3.38 μg/mL