- Natural product: Goldenseal (Hydrastis canadensis)
 - Associated study: An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents
 
In Vitro Enzyme Inhibition Experiment
2D6 Inhibition by Aq GS Extract
Inhibition was detected. Cutoff used — not specified
- CYP2D6 4173631
 
Cell fraction Pooled human liver microsomes -7999662
Results
Estimate Fig 1 at 20 μM
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates | 
|---|
Experimental Conditions
                                                            
                                                                In-house preparation
                                                                
                                                                
                                                            
                                                        
HHM-247 and HHM-258
15 min
                                                            
                                                                NADPH
                                                                
                                                                
                                                            
                                                        
10 min
                                                            
                                                                No NADPH with precipitant
                                                                
                                                                
                                                            
                                                        
1 or 20 μM