- Natural product: Green tea (Camellia sinensis)
- Associated study: Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein
In Vitro Transporter Inhibition Experiment
Inhibition of OATP1B1 by (-)-epigallocatechin gallate
Non-inhibition was detected. Cutoff used — NA
- OATP1B1 (SLCO1B1)
Transfected / siRNA knock-out / injected cells HEK293 transfected cells
Results
Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
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Experimental Conditions
7.0 x 10^5 cells/well
12-well poly-D-lysine coated plates
48 h
5 min
37 deg C
0.05 µM
100 µM
Prof. Toshiyuki Kan (Department of Synthetic Organic and Medicinal Chemistry, University of Shizuoka, Japan)