In Vitro Transporter Kinetics Experiment

Metformin uptake in OCT2 cells

Transport Activity was detected.  Cutoff used — NA

metformin 1503297

  • OCT2 (SLC22A2)

Transfected / siRNA knock-out / injected cells HEK293 transfected cells

Results

Sample Compound measured Value Measurement Study sequence Additional information N replicates
metformin69-foldRatio of Fold Accumulation Transfected / Vector Control
Mean		Test
P-value:
P < 0.005
4

Experimental Conditions

Cell Culture Conditions

7.0 x 10^5 cells/well

12-well poly-D-lysine coated plates

48 h

Assay Conditions

10 min

37 deg C

10 µM