In Vitro Enzyme Inhibition Experiment

Negligible inhibition of CYP2A6 by Licochalcone A

Negligible Inhibition was detected.  Cutoff used —

> 25 µg/ml

coumarin 19008106

licochalcone a

7-hydroxycoumarin

  • CYP2A6 4309826

Cell fraction Pooled human liver microsomes -7999662

Results

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

0.2 mg/mL

10 min

NADPH

1.5 μM

11 concentrations from 0.005–250 μg/mL