- Natural product: Green tea (Camellia sinensis)
- Associated study: Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation
In Vitro Enzyme Inhibition Experiment
Inhibition of UGT1A1 and 1A8 by Green Tea Leaf Extract (T21) (Ki determination)
Inhibition was detected. Cutoff used — Not provided.
- UGT1A1 40782950
- UGT1A8
Cell fraction Pooled human intestinal microsomes -7999663
Methanol extract of a widely avaliable commercial green tea leaf (T21, 200 mg) chemically similar to the National Institute of Standards and Technology (NIST) green tea leaf reference was used. Information regarding enzymes involved in the formation of raloxifene metabolites was obtained from Gufford et al., 2015 (Drug Metab Dispos. 2015 Sep;43(9):1353-9).
Results
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
0.05 mg/mL
Commercially available
1410074
4 min
UDPGA
Not available
Not available
0.25-10 µM
2.5-40 µg/mL