In Vitro Enzyme Inhibition Experiment

Inhibition of UGT1A1, 1A8, and 1A10 by (-)-Epigallocatechin (Screening)

Inhibition was detected.  Cutoff used — 50% inhibition vs. control

raloxifene 1513103


raloxifene 6-glucuronide

  • UGT1A1 40782950
  • UGT1A10
  • UGT1A8

Cell fraction Pooled human intestinal microsomes -7999663

Information regarding enzymes involved in the formation of raloxifene metabolites was obtained from Gufford et al., 2015 (Drug Metab Dispos. 2015 Sep;43(9):1353-9).


At 10 µM (-)-epigallocatechin did not signficiantly inhibit the formation of raloxifene 6-glucuronide. Percent inhibition value was estimated from Fig. S2.

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

Commercially available


Not available

Not available

100 µM

Control Experiment