Cannabis (Cannabis sativa)
Enhanced biotransformation of theophylline in marihuana and tobacco smokers.
CSV
JSON
Single oral doses of theophylline were administered to 7 chronic marihuana smokers, to 7 chronic users of both marihuana and tobacco, and to 43 appropriate control subjects. Theophylline was cleared from the blood more rapidly in both marihuana and tobacco smokers with a mean increase in total clearance from 52 ml/kg/hr in nonsmokers to 74 ml/kg/hr in subjects who smoked either material alone. There was an additive increase in clearance to 93 ml/kg/hr in those who smoked both substances. Concern over enhanced metabolism of other drugs is probably warranted in tobacco and cannabis smokers.
1 . Decreased systemic exposure of Theophylline with Smoked Marihuana (non Tobacco smoker) (id=NPDI-P9f-Mw)
In Vivo Interaction Study
Increased systemic exposure was detected.
theophylline 1237049
caffeine 1134439
Results
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
Parallel
Females
Males
Healthy alcohol drinking
7
5 males and 2 females
Drug or Natural Product Administration
Oral
orange juice
5 mg/kg
12h
Inhalation
plant
n/a
2 . Decreased systemic exposure of Theophylline with Smoked Marihuana (Tobacco smoker) (id=NPDI-RUuAkA)
In Vivo Interaction Study
Decreased systemic exposure was detected.
theophylline 1237049
caffeine 1134439
Results
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
Parallel
Females
Males
Healthy alcohol drinking
Smokers
7
3 males and 4 females
Drug or Natural Product Administration
Oral
orange juice
5 mg/kg
12h
Inhalation
plant
n/a
3 . Decreased systemic exposure of Theophylline with Smoked Tobacco (no Marihuana smoker) (id=NPDI-6t3-aw)
In Vivo Interaction Study
Decreased systemic exposure was detected.
theophylline 1237049
caffeine 1134439
Results
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
Parallel
Females
Males
Healthy alcohol drinking
Smokers
24
5 males and 19 females