2D6 pre-incubation with NADPH CSV JSON

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In Vitro Enzyme Inhibition Experiment

2D6 pre-incubation with NADPH

Inhibition was detected.  Cutoff used — not specified


berberine 19012197


  • CYP2D6 4173631

Recombinant expression system Baculovirus-insect cells
Cytochrome B5 No


Estimated from fig 2 at 30 mins
Table 2

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

100-pmol CYP/mg

Commercially available


400 μL

25 min

NADPH regenerating system
P450 reductase

100 μM

0,5,15,30, and 45 min

NADPH with precipitant