NaPDI | Compound details

Need public description.

Natural products containing this compound

Enantiomer of compound
None listed

Compound has enantiomers
None listed

Metabolite of compounds
None listed

Compound has metabolites

6beta-hydroxytestosterone

Column visibility

Showing 1 to 32 of 32 entries

Search:

ID	Subject of Study	Study Name	Name	Type	Overall Effect	Enzymes	Object	Object Metabolite	Precipitant
NPDI--eqgUQ	Licorice (Glycyrrhiza uralensis)	Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents	Negligible inhibition of CYP3A4 by G. uralensis Licorice extract	In Vitro Enzyme Inhibition	negative — In Vitro Enzyme Negligible Inhibition	CYP3A4	testosterone	6beta-hydroxytestosterone	ethanolic extract of licorice g. uralensis
NPDI-1ijwVg	Goldenseal (Hydrastis canadensis)	An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents	3A4 Inhibition by Berberine (Testosterone)	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP3A4	testosterone	6beta-hydroxytestosterone	berberine
NPDI-2seH4Q	Kratom (Mitragyna speciosa)	Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids	Weak Inhibition of Speciociliatine for CYP3A4/5	In Vitro Enzyme Inhibition	negative — In Vitro Enzyme Negligible Inhibition	CYP3A4 CYP3A5	testosterone	6beta-hydroxytestosterone	speciociliatine
NPDI-39rhWg	Goldenseal (Hydrastis canadensis)	Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components	3A4 Inhibition by (+) Hydrastine	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP3A4	testosterone	6beta-hydroxytestosterone	hydrastine
NPDI-5wiIYg	Goldenseal (Hydrastis canadensis)	An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents	3A4 Inhibition by Hydrastine (Testosterone)	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP3A4	testosterone	6beta-hydroxytestosterone	hydrastine
NPDI-92ORyA	glycyrrhetinic acid	Inhibition of CYP enzymes by glycyrrhetinic acid	Inhibition of CYP3A4 by 18-beta-Glycyrrhetinic acid	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP3A4	testosterone	6beta-hydroxytestosterone	glycyrrhetinic acid
NPDI-9xzv_Q	Kratom (Mitragyna speciosa)	Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids	Control Positive Inhibition for CYP3A4/5	In Vitro Enzyme Inhibition (Control experiment)	positive — In Vitro Enzyme Inhibition	CYP3A4 CYP3A5	testosterone	6beta-hydroxytestosterone	ketoconazole
NPDI-_D6yiA	Goldenseal (Hydrastis canadensis)	Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components	3A4 Inhibition by Berberine	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP3A4	testosterone	6beta-hydroxytestosterone	berberine
NPDI-aNb3lw	Kratom (Mitragyna speciosa)	Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids	Weak Inhibition of Paynantheine for CYP3A4/5	In Vitro Enzyme Inhibition	negative — In Vitro Enzyme Negligible Inhibition	CYP3A4 CYP3A5	testosterone	6beta-hydroxytestosterone	paynantheine
NPDI-beIHRg	Licorice (Glycyrrhiza inflata)	Cytochrome P450 inhibition by licorice species Glycyrrhiza inflata and fourteen licorice constituents	Inhibition of CYP3A4 by G. inflata Licorice extract	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP3A4	testosterone	6beta-hydroxytestosterone	ethanolic extract of licorice g. inflata
NPDI-BLzT_g	Kratom (Mitragyna speciosa)	Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids	Weak Inhibition of Mitragynine for CYP3A4/5	In Vitro Enzyme Inhibition	negative — In Vitro Enzyme Negligible Inhibition	CYP3A4 CYP3A5	testosterone	6beta-hydroxytestosterone	mitragynine
NPDI-CDvKlQ	Goldenseal (Hydrastis canadensis)	Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components	3A4 Inhibition by (-) Hydrastine	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP3A4	testosterone	6beta-hydroxytestosterone	(-)-beta-hydrastine
NPDI-cYwbww	Goldenseal (Hydrastis canadensis)	An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents	3A4 Inhibition by Aq GS Extract (Testosterone)	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP3A4	testosterone	6beta-hydroxytestosterone	aqueous goldenseal extract
NPDI-DDS1fQ	licoricidin	Inhibition of CYP enzymes by licoricidin	Inhibition of CYP3A4 by Licoricidin	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP3A4	testosterone	6beta-hydroxytestosterone	licoricidin
NPDI-EjO7dA	berberine	Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs	1A2 preincubation with NADPH	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP1A2	testosterone	6beta-hydroxytestosterone	berberine
NPDI-fM7Sfg	Cannabis (Cannabis sativa)	Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450	11-OH-THC Inhibition on CYP3A	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP3A	testosterone	6beta-hydroxytestosterone	11-hydroxy-delta-9-tetrahydrocannabinol
NPDI-hthN8w	Cannabis (Cannabis sativa)	Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450	CBD Inhibition on CYP3A	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP3A	testosterone	6beta-hydroxytestosterone	cannabidiol
NPDI-iASYyA	Kratom (Mitragyna speciosa)	Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids	Weak Inhibition of 7-hydroxymitragynine for CYP3A4/5	In Vitro Enzyme Inhibition	negative — In Vitro Enzyme Negligible Inhibition	CYP3A4 CYP3A5	testosterone	6beta-hydroxytestosterone	7-hydroxymitragynine
NPDI-ibIkjQ	Goldenseal (Hydrastis canadensis)	An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents	3A4 Inhibition by Ethanolic GS Extract (Testosterone)	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP3A4	testosterone	6beta-hydroxytestosterone	ethanolic goldenseal extract
NPDI-iBWK6Q	berberine	Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs	3A4 preincubation without NADPH	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP3A4	testosterone	6beta-hydroxytestosterone	berberine
NPDI-itM3Yw	Licorice (Glycyrrhiza glabra)	Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents	Inhibition of CYP3A4 by G. glabra Licorice extract	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP3A4	testosterone	6beta-hydroxytestosterone	ethanolic extract of licorice g. glabra
NPDI-MsX4aw	berberine	Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs	1A2 preincubation without NADPH	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP1A2	testosterone	6beta-hydroxytestosterone	berberine
NPDI-NUpDbg	licochalcone a	Inhibition of CYP enzymes by licochalcone a	Inhibition of CYP3A4 by Licochalcone A	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP3A4	testosterone	6beta-hydroxytestosterone	licochalcone a
NPDI-OCQ06Q	Goldenseal (Hydrastis canadensis)	Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components	3A4 Inhibition by GS Extract	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP3A4	testosterone	6beta-hydroxytestosterone	goldenseal root extract
NPDI-P2Nw6g	Kratom (Mitragyna speciosa)	Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids	Weak Inhibition of Speciogynine for CYP3A4/5	In Vitro Enzyme Inhibition	negative — In Vitro Enzyme Negligible Inhibition	CYP3A4 CYP3A5	testosterone	6beta-hydroxytestosterone	speciogynine
NPDI-q61pww	berberine	Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs	3A4 preincubation with NADPH	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP3A4	testosterone	6beta-hydroxytestosterone	berberine
NPDI-qMnZyA	Kratom (Mitragyna speciosa)	Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids	Weak Inhibition of Corynantheidine for CYP3A4/5	In Vitro Enzyme Inhibition	negative — In Vitro Enzyme Negligible Inhibition	CYP3A4 CYP3A5	testosterone	6beta-hydroxytestosterone	corynantheidine
NPDI-Rm0CoQ	Cannabis (Cannabis sativa)	Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450	THC Inhibition on CYP3A	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP3A	testosterone	6beta-hydroxytestosterone	delta-9-tetrahydrocannabinol
NPDI-uw6NfQ	isoliquiritigenin	Inhibition of CYP enzymes by isoliquiritigenin	Inhibition of CYP3A4 by Isoliquiritigenin	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP3A4	testosterone	6beta-hydroxytestosterone	isoliquiritigenin
NPDI-wjO31A	berberine	Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs	2D6 preincubation without NADPH	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP2D6	testosterone	6beta-hydroxytestosterone	berberine
NPDI-wz4NXQ	glabridin	Inhibition of CYP enzymes by glabridin	Inhibition of CYP3A4 by Glabridin	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP3A4	testosterone	6beta-hydroxytestosterone	glabridin
NPDI-ykfGxQ	berberine	Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs	2D6 pre-incubation with NADPH	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP2D6	testosterone	6beta-hydroxytestosterone	berberine

records per page

Column visibility

Showing 1 to 13 of 13 entries

Search:

ID	Subject of Study	Name
NPDI-8SkM4A	Licorice (Glycyrrhiza glabra)	Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents
NPDI-agZaLg	Goldenseal (Hydrastis canadensis)	Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components
NPDI-bQlJCA	isoliquiritigenin	Inhibition of CYP enzymes by isoliquiritigenin
NPDI-EiXGKA	Goldenseal (Hydrastis canadensis)	An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents
NPDI-eReNjw	Kratom (Mitragyna speciosa)	Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids
NPDI-JcMOhg	berberine	Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs
NPDI-lalKkg	Cannabis (Cannabis sativa)	Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450
NPDI-Lm3PvA	Licorice (Glycyrrhiza uralensis)	Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents
NPDI-N-qGfA	glabridin	Inhibition of CYP enzymes by glabridin
NPDI-oEAKVw	licochalcone a	Inhibition of CYP enzymes by licochalcone a
NPDI-OYnBGA	glycyrrhetinic acid	Inhibition of CYP enzymes by glycyrrhetinic acid
NPDI-qiyzaQ	licoricidin	Inhibition of CYP enzymes by licoricidin
NPDI-UmIRAQ	Licorice (Glycyrrhiza inflata)	Cytochrome P450 inhibition by licorice species Glycyrrhiza inflata and fourteen licorice constituents

records per page

Compound information from external resources

Resource	Identifier
Google search	MUMGGOZAMZWBJJ-DYKIIFRCSA-N

testosterone
InChIKey: MUMGGOZAMZWBJJ-DYKIIFRCSA-N

Compound information managed by NaPDI

Compound information from external resources

External Resources

NOTE

testosterone InChIKey: MUMGGOZAMZWBJJ-DYKIIFRCSA-N

Compound information managed by NaPDI

Compound information from external resources

External Resources

testosterone
InChIKey: MUMGGOZAMZWBJJ-DYKIIFRCSA-N