Negligible inhibition of CYP3A4 by G. uralensis Licorice extract CSV JSON

In Vitro Enzyme Inhibition Experiment

Negligible inhibition of CYP3A4 by G. uralensis Licorice extract

Negligible Inhibition was detected.  Cutoff used —

> 100 µg/mL

midazolam 708298

1'-hydroxymidazolam

  • CYP3A4 4306811

Cell fraction Pooled human liver microsomes -7999662

Results

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

0.2 mg/mL

10 min

NADPH

2.5 µM

11 concentrations from 0.005–250 μg/mL