Inhibition of CYP2D6 by (-)-Epigallocatechin Gallate in HLM (Ki Determination) CSV JSON

In Vitro Enzyme Inhibition Experiment

Inhibition of CYP2D6 by (-)-Epigallocatechin Gallate in HLM (Ki Determination)

Inhibition was detected.  Cutoff used — Ki determination

dextromethorphan 1119510

dextrorphan 4349487

  • CYP2D6 4173631

Cell fraction Pooled human liver microsomes -7999662

Results

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

0.1 mg/mL

Commercially available

100 µL

10 min

NADPH

Not available

Not available

1.3-5.4 µM

1-218 µM