Down regulation of P-gp mRNA expression by 1 µM quinidine CSV JSON

In Vitro Transporter Induction Experiment

Down regulation of P-gp mRNA expression by 1 µM quinidine

Down Regulation was detected.  Cutoff used —

p < 0.05 compared with control

quinidine

  • P-gp (ABCB1)

Cell system Caco-2 cells

Results

% Inhibition mean taken from text. SD estimated from Figure 3b.

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

mRNA expression

1 µM

72 h

Reverse transcription-quantitative real-time PCR