- Natural product: Kratom (Mitragyna speciosa)
- Associated study: Clinical Pharmacokinetic Assessment of Kratom (Mitragyna speciosa), a Botanical Product with Opioid-like Effects, in Healthy Adult Participants
In Vivo Pharmacokinetics Study
mitragynine
Results
Data from 5 healthy adults who completed the study (out of 7 enrolled) was used to calculate the compartmental model-derived pharmacokinetic estimates.
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
Probe cocktail study
Healthy volunteers
More than one race
7
The six participants self-identified as White (one male and three females), Black (one male), or multiracial (one male). Participant age ranged from 26–40 years. None of the participants failed the drug toxicology screen, and all abstained from taking concomitant medications and botanical and other natural products during the entire study period. Except for the two discontinued female participants, the kratom tea was well tolerated, and none of the participants experienced any severe adverse events. Two participants experienced an adverse event during the study unrelated to kratom (lightheadedness upon placement of an intravenous catheter/first blood draw and mild headache, respectively) that did not result in study discontinuation.
Drug or Natural Product Administration
Oral
2 g