ID Natural Product Investigated Study Name Number of Experiments Status
NPDI-XM-YzA Green tea (Camellia sinensis) Green Tea Characterization of Material 1
NPDI-Em0b2g Goldenseal (Hydrastis canadensis) Goldenseal Characterization of Material 1
NPDI-i4m0FA Cannabis (Cannabis sativa) Cannabis Characterization of Bulk Plant Material 1
NPDI-8SkM4A Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents 11
NPDI-vQCHYg Kratom (Mitragyna speciosa) Characterization of Kratom material 1
NPDI-Lm3PvA Licorice (Glycyrrhiza uralensis) Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents 11
NPDI-UmIRAQ Licorice (Glycyrrhiza inflata) Cytochrome P450 inhibition by licorice species Glycyrrhiza inflata and fourteen licorice constituents 11
NPDI-4xNSSg Kratom (Mitragyna speciosa) Evaluation of In Vitro Absorption, Distribution, Metabolism, and Excretion (ADME) Properties of Mitragynine, 7-Hydroxymitragynine, and Mitraphylline 8
NPDI-K89fCg Green tea (Camellia sinensis) Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E. 8
NPDI-9V_SXw Cannabis (Cannabis sativa) Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19. 4
NPDI-yBr48Q Goldenseal (Hydrastis canadensis) The Effects of Berberine on the Pharmacokinetics of Ciclosporin A in Healthy Volunteers 2
NPDI-eReNjw Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids 42
NPDI-FfN_4A Kratom (Mitragyna speciosa) Evaluation of the Effects of Mitragyna speciosa Alkaloid Extract on Cytochrome P450 Enzymes Using a High Throughput Assay 4
NPDI-l4wD_A glycycoumarin Inhibition of CYP enzymes by glycycoumarin 5
NPDI-XtvOZQ Kratom (Mitragyna speciosa) Inhibitory effect of mitragynine on human cytochrome P450 enzyme activities 9
NPDI-BvR0Pw Cannabis (Cannabis sativa) Pharmacological Effects of Cannabinoids on the Caco-2 Cell Culture Model of Intestinal Permeability 2
NPDI-EiXGKA Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 25
NPDI-pHkLHA Goldenseal (Hydrastis canadensis) An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures 1
NPDI-UXOaUA Cannabis (Cannabis sativa) A phase I study to assess the effect of food on the single dose bioavailability of the THC/CBD oromucosal spray 6
NPDI-PSB8Vg Kratom (Mitragyna speciosa) Evaluation of selected Malaysian medicinal plants on phase I drug metabolizing enzymes, CYP2C9, CYP2D6 and CYP3A4 activities in vitro 6
NPDI-N-qGfA glabridin Inhibition of CYP enzymes by glabridin 1
NPDI-OYnBGA glycyrrhetinic acid Inhibition of CYP enzymes by glycyrrhetinic acid 2
NPDI-luckpg Goldenseal (Hydrastis canadensis) An ex vivo approach to botanical-drug interactions: A proof of concept study 5
NPDI-dIgOyA Kratom (Mitragyna speciosa) Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom) 1
NPDI-d8OUzg Kratom (Mitragyna speciosa) Refined Prediction of Pharmacokinetic Kratom-Drug Interactions: Time-Dependent Inhibition Considerations 19
NPDI-vniY7Q Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. 15
NPDI-SiYA_A Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) 14
NPDI-jEZ9Ng Goldenseal (Hydrastis canadensis) Differential inhibition of CYP1-catalyzed regioselective hydroxylation of estradiol by berberine and its oxidative metabolites 2
NPDI-JHPnhA Kratom (Mitragyna speciosa) The inhibitory effects of mitragynine on P-glycoprotein in vitro 9
NPDI-sUzV-g Cannabis (Cannabis sativa) Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids 8
NPDI-aujB5A Green tea (Camellia sinensis) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes 12
NPDI-cM9pfg Cannabis (Cannabis sativa) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. 6
NPDI-r7lzqQ zidovudine Inhibition of UGT2B7 Enzyme Activity in Human and Rat Liver Microsomes by Herbal Constituents 6
NPDI-7LwuzA Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein 18
NPDI-utgZiA Green tea (Camellia sinensis) Plasma pharmacokinetics of catechin metabolite 4'-O-Me-EGC in healthy humans 1
NPDI-5Mf9Qw Goldenseal (Hydrastis canadensis) The Effect of Oxidation on Berberine-Mediated CYP1 Inhibition: Oxidation Behavior and Metabolite-Mediated Inhibition 4
NPDI-zg6Npw Green tea (Camellia sinensis) Inhibitory effects of commonly used herbal extracts on UDP-glucuronosyltransferase 1A4, 1A6, and 1A9 enzyme activities 3
NPDI-dCfz1g Green tea (Camellia sinensis) Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450 13
NPDI-qiyzaQ licoricidin Inhibition of CYP enzymes by licoricidin 5
NPDI-JcMOhg berberine Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs 6
NPDI-xYeUJQ Cannabis (Cannabis sativa) Influence of cannabidiol on secobarbital effects and plasma kinetics 3
NPDI-Rvn9SQ Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes 18
NPDI-vhBMSw Cannabis (Cannabis sativa) Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse 6
NPDI-ieYYdA Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. 12
NPDI-1wiJBw Cannabis (Cannabis sativa) Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines. 15
NPDI-EngCtg Cannabis (Cannabis sativa) Medicinal Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel 2
NPDI-l0yevQ Cannabis (Cannabis sativa) CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells 2
NPDI-oEAKVw licochalcone a Inhibition of CYP enzymes by licochalcone a 10
NPDI-rmRb0A Goldenseal (Hydrastis canadensis) Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study 2
NPDI--2FOpA Green tea (Camellia sinensis) Pharmacokinetics and Safety of Green Tea Polyphenols after Multiple-Dose Administration of Epigallocatechin Gallate and Polyphenon E in Healthy Individuals 1
NPDI-agZaLg Goldenseal (Hydrastis canadensis) Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components 12
NPDI-VYyv-A Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes 9
NPDI-euNEwQ Cannabis (Cannabis sativa) Cannabidiol enhances xenobiotic permeability through the human placental barrier by direct inhibition of breast cancer resistance protein: an ex vivo study. 3
NPDI-m-U3YQ Cannabis (Cannabis sativa) The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids. 3
NPDI-OeAReg Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation 24
NPDI-BUBqZg Ceylon cinnamon (Cinnamomum verum) Mechanisms of Herb-Drug Interactions Involving Cinnamon and CYP2A6: Focus on Time-Dependent Inhibition by Cinnamaldehyde and 2-Methoxycinnamaldehyde 6
NPDI-lY9NZQ Cannabis (Cannabis sativa) Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells 3
NPDI-6yhsoA Green tea (Camellia sinensis) Effects of repeated green tea catechin administration on human cytochrome P450 activity. 4
NPDI-6PgT2w Kratom (Mitragyna speciosa) Kratom Metabolomics 1
NPDI-47DSLg Goldenseal (Hydrastis canadensis) Effects of Herbal Products and their Constituents on Human Cytochrome P4502E1 Activity 3
NPDI-uPn_2w Cannabis (Cannabis sativa) Enhanced biotransformation of theophylline in marihuana and tobacco smokers. 3
NPDI-d4aGfw Cannabis (Cannabis sativa) In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites 9
NPDI-rRRoQw Goldenseal (Hydrastis canadensis) Inhibition of organic cation transporter 2 and 3 may be involved in the mechanism of the antidepressant-like action of berberine 3
NPDI-ahQtSQ Cannabis (Cannabis sativa) Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1) 6
NPDI-9C7QHg Kratom (Mitragyna speciosa) Effects of mitragynine and 7-hydroxymitragynine (the alkaloids of Mitragyna speciosa Korth) on 4-methylumbelliferone glucuronidation in rat and human liver microsomes and recombinant human uridine 5’- diphospho-glucuronosyltransferase isoforms 15
NPDI-Z6vbAA Cannabis (Cannabis sativa) Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol 4
NPDI-yvZDKA Green tea (Camellia sinensis) Green tea (Camellia sinensis) extract does not alter cytochrome P450 3A4 or 2D6 activity in healthy volunteers. 2
NPDI-SPpDlg Goldenseal (Hydrastis canadensis) Enzyme-inducing effects of berberine on cytochrome P450 1A2 in vitro and in vivo 2
NPDI-ftEv0g Goldenseal (Hydrastis canadensis) In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4 phenotypes 4
NPDI-O4gNrA Goldenseal (Hydrastis canadensis) A clinical study of transporter-mediated goldenseal drug interactions 5
NPDI--aO6Bw Goldenseal (Hydrastis canadensis) Identification of novel dietary phytochemicals inhibiting the efflux transporter breast cancer resistance protein (BCRP/ABCG2) 2
NPDI-5XFThQ Goldenseal (Hydrastis canadensis) Repeated administration of berberine inhibits cytochromes P450 in humans 5
NPDI-ZfxNfg Goldenseal (Hydrastis canadensis) Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1) 3
NPDI-Ujn_7A Cannabis (Cannabis sativa) Structural requirements for potent direct inhibition of human cytochrome P450 1A1 by cannabidiol: role of pentylresorcinol moiety. 5
NPDI-twVQgQ Goldenseal (Hydrastis canadensis) Supplementation With Goldenseal (Hydrastis canadensis), but not Kava Kava (Piper methysticum), Inhibits Human CYP3A Activity In Vivo 1
NPDI-zlH6uA Cannabis (Cannabis sativa) Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes 4
NPDI-Yknaag Kratom (Mitragyna speciosa) P-glycoprotein interactions of novel psychoactive substances – Stimulation of ATP consumption and transport across Caco-2 monolayers 2
NPDI-iHWMgQ Cannabis (Cannabis sativa) Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. 6
NPDI-qOTUkQ Cannabis (Cannabis sativa) The effects of cannabinoids on the pharmacokinetics of indinavir and nelfinavir 2
NPDI-ZqVOgw Cannabis (Cannabis sativa) Interaction between naltrexone and oral THC in heavy marijuana smokers 1
NPDI-uO_CeA Goldenseal (Hydrastis canadensis) Inhibition of P-Glycoprotein by HIV Protease Inhibitors Increases Intracellular Accumulation of Berberine in Murine and Human Macrophages 3
NPDI-FhBdoQ Cannabis (Cannabis sativa) Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). 2
NPDI-RTaSkA Green tea (Camellia sinensis) Inhibitory effects of various beverages on ritodrine sulfation by recombinant human sulfotransferase isoforms SULT1A1 and SULT1A3 4
NPDI-dBrDOg Goldenseal (Hydrastis canadensis) Human MDR1 and MRP1 Recognize Berberine as Their Transport Substrate 1
NPDI-UC_DUA Green tea (Camellia sinensis) Blood and Urine Levels of Tea Catechins after Ingestion of Different Amounts of Green Tea by Human Volunteers 3
NPDI-8lgFiA Cannabis (Cannabis sativa) Interaction between Marihuana and Ethanol: Effects on Psychomotor Performance 3
NPDI-bQlJCA isoliquiritigenin Inhibition of CYP enzymes by isoliquiritigenin 3
NPDI-Szj4NQ Green tea (Camellia sinensis) Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects. 3
NPDI-4zmpGg Goldenseal (Hydrastis canadensis) Time-Dependent Inhibition of CYP2C19 by Isoquinoline Alkaloids: In Vitro and In Silico Analysis 1
NPDI-sv6smA Goldenseal (Hydrastis canadensis) Goldenseal Metabolomics 1
NPDI-hKjwcg Goldenseal (Hydrastis canadensis) Organic anion-transporting polypeptides contribute to the hepatic uptake of berberine 2
NPDI-fLne_g Goldenseal (Hydrastis canadensis) Influence of Goldenseal Root on the Pharmacokinetics of Indinavir 1
NPDI-gTt8Dw Cannabis (Cannabis sativa) Safety and pharmacokinetics of oral cannabidiol when administered concomitantly with intravenous fentanyl in humans 1
NPDI-UaGLOg Cannabis (Cannabis sativa) Characterization of P-glycoprotein Inhibition by Major Cannabinoids from Marijuana 1
NPDI-jCrpqg Green tea (Camellia sinensis) Green Tea Metabolomics 1
NPDI-C-vzvw Goldenseal (Hydrastis canadensis) Poor permeability and absorption affect the activity of four alkaloids from Coptis 2
NPDI-S1YNJQ Green tea (Camellia sinensis) Inhibitory effects of commonly used herbal extracts on UGT1A1 enzyme activity. 1
NPDI-rREhEQ Goldenseal (Hydrastis canadensis) Tetrandrine Potentiates the Hypoglycemic Efficacy of Berberine by Inhibiting P-Glycoprotein Function 1
NPDI-Tq41aQ Goldenseal (Hydrastis canadensis) In Vivo and in Vitro Study on Drug-Drug Interaction of Lovastatin and Berberine from Pharmacokinetic and HepG2 Cell Metabolism Studies 1
NPDI-Asg_wA Cannabis (Cannabis sativa) Does olanzapine inhibit the psychomimetic effects of Δ9-tetrahydrocannabinol? 1