Cannabis (Cannabis sativa)
Warfarin dose adjustment required after cannabidiol initiation and titration CSV JSON

A case of a possible interaction between cannabidiol and warfarin is presented along with a brief overview of cytochrome enzymes involved in these drugs' metabolism.

Cannabis (Cannabis sativa)

33016308

Case Report DIPS
Question
1. Are there previous credible reports in humans?YesYes
2. Is the interaction consistent with known interactive properties of the precipitant drug?YesYes
3. Is the interaction consistent with known interactive properties of the object drug?YesYes
4. Is the event consistent with the known or reasonable time course of the interaction (onset and/or offset)?YesYes
5. Did the interaction remit upon de-challenge of the precipitant drug with no change in the object drug?NANA
6. Did the interaction reappear when the precipitant drug was re-administered with continued use of object drug?SkippedSkipped
7. Are there reasonable alternative causes?YesYes
8. Was the object drug detected in the blood or other fluids in concentrations consistent with the interaction?NoUnk/NA
9. Was the drug interaction confirmed by objective evidence consistent with the effects on the object drug (other than from question 8)?NoNA
10. Was the interaction greater when the precipitant drug dose was increased or less when the precipitant drug dose was decreased?YesYes
(>8 = Highly Probable; 5-8 = Probable; 2-4 = Possible; <2 = Doubtful)