Cannabis (Cannabis sativa)
Enhanced biotransformation of theophylline in marihuana and tobacco smokers. CSV JSON

Single oral doses of theophylline were administered to 7 chronic marihuana smokers, to 7 chronic users of both marihuana and tobacco, and to 43 appropriate control subjects. Theophylline was cleared from the blood more rapidly in both marihuana and tobacco smokers with a mean increase in total clearance from 52 ml/kg/hr in nonsmokers to 74 ml/kg/hr in subjects who smoked either material alone. There was an additive increase in clearance to 93 ml/kg/hr in those who smoked both substances. Concern over enhanced metabolism of other drugs is probably warranted in tobacco and cannabis smokers.

Cannabis (Cannabis sativa)

688731

1 . Decreased systemic exposure of Theophylline with Smoked Marihuana (non Tobacco smoker) (id=NPDI-P9f-Mw)

In Vivo Interaction Study

Increased systemic exposure was detected.

theophylline 1237049

medicinal cannabis

Results

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

Parallel

Population

Females
Males

Healthy alcohol drinking

7

5 males and 2 females

Drug or Natural Product Administration

Object Administration — theophylline

Oral

orange juice

5 mg/kg

12h

Precipitant Administration — medicinal cannabis

Inhalation

plant

n/a

2 . Decreased systemic exposure of Theophylline with Smoked Marihuana (Tobacco smoker) (id=NPDI-RUuAkA)

In Vivo Interaction Study

Decreased systemic exposure was detected.

theophylline 1237049

medicinal cannabis

Results

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

Parallel

Population

Females
Males

Healthy alcohol drinking
Smokers

7

3 males and 4 females

Drug or Natural Product Administration

Object Administration — theophylline

Oral

orange juice

5 mg/kg

12h

Precipitant Administration — medicinal cannabis

Inhalation

plant

n/a

3 . Decreased systemic exposure of Theophylline with Smoked Tobacco (no Marihuana smoker) (id=NPDI-6t3-aw)

In Vivo Interaction Study

Decreased systemic exposure was detected.

theophylline 1237049

medicinal cannabis

Results

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

Parallel

Population

Females
Males

Healthy alcohol drinking
Smokers

24

5 males and 19 females