Green tea (Camellia sinensis)
Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects.
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This study aimed to evaluate the effects of green tea on the pharmacokinetics and pharmacodynamics of the β-blocker nadolol. The study includes a trasport experiment using cells stably expressing the organic anion–transporting polypeptides OATP1A2 and OATP2B1.
1 . OATP1A2 in vitro inhibition (id=NPDI-wYUfKA)
In Vitro Transporter Inhibition Experiment
Inhibition was detected. Cutoff used — not clearly specified
nadolol 1313200
- OATP1A2 (SLCO1A2)
Transfected / siRNA knock-out / injected cells HEK293 transfected cells
Results
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
poly-D-lysine hydrobromide-coated 12-well plates
2
5 min
37 deg C
7.3
100 µM
1, 10, 100, and 1000 µM
not specified
2 . OATP1A2 inhibition with green tea (id=NPDI-lih1tg)
In Vitro Transporter Inhibition Experiment
Inhibition was detected. Cutoff used — Not provided
nadolol 1313200
- OATP1A2 (SLCO1A2)
Transfected / siRNA knock-out / injected cells HEK293 transfected cells
Results
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
poly-D-lysine hydrobromide-coated 12-well plates
2
5 min
37 deg C
7.3
100 µM
0.1 - 10% (10:100 dilution of green tea)
commercial green tea beverage (Healthya; Kao, Tokyo, Japan)
1 . Green tea interaction with nadolol (id=NPDI-i6A3tw)
In Vivo Interaction Study
Increased systemic exposure was detected.
nadolol 1313200
- OATP1A2 (SLCO1A2)
This study suggests that green tea reduces plasma concentrations of nadolol possibly in part by inhibition of OATP1A2-mediated uptake of nadolol in the intestine.
Results
For AUC change, P < 0.001 (currently no such option in the build).
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
Fixed-sequence
Healthy volunteers
Nonsmokers
Asian
10
Ten Japanese subjects including eight males and two females; age: 20–30 years; body mass index: 18.3–23.9 kg/m 2
predose (0 h) and at 0.5, 1, 2, 3, 4, 6, 8, 24, and 48 h after nadolol administration
Drug or Natural Product Administration
Oral
not provided
30 mg
single dose
Oral
liquid
700 mL
once daily
14 days
commercial green tea beverage (Healthya; Kao, Tokyo, Japan)
2013
Pharmacodynamics (PD) & Adverse Events
As PD tests, PR, SBP, and DBP were recorded after 10 min rest in a sitting position at predose and at 0.5, 1, 2, 3, 4, 8, 24, and 48 h after nadolol administration using an automatic blood pressure monitor.
Cardiac disorders
35200000
In the water phase, nadolol lowered PR, SBP, and DBP, with maximum decreases of 20, 12, and 11%, respectively, based on arithmetic means. Coadministration of green tea tended to reduce the PD responses to nadolol in all parameters. In particular, green tea significantly suppressed the SBP-lowering effect of nadolol.