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  • Green Tea (Camellia sinensis)

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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-VWdSJg Green Tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of OATP1B1 by Green Tea Leaf In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • OATP1B1 (SLCO1B1)
bromosulfophthalein green tea leaf
NPDI-FBHH1Q Green Tea (Camellia sinensis) Effects of repeated green tea catechin administration on human cytochrome P450 activity. In Vivo Interaction negative — No Effect (based on bioequivalence limits)
  • CYP2D6
dextromethorphan green tea leaf
NPDI-PRsP6g Green Tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of P-gp by Green Tea In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
digoxin green tea leaf
NPDI-nm2fYg Green Tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of OCT2 by Green Tea In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • OCT2 (SLC22A2)
metformin green tea leaf
NPDI-mLlCzw Green Tea (Camellia sinensis) Inhibitory effects of various beverages on ritodrine sulfation by recombinant human sulfotransferase isoforms SULT1A1 and SULT1A3 Green tea inhibition of SULT1A1 using 4-nitrophenyl as the substrate In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • SULT1A1
p-nitrophenol 4-nitrophenyl sulfate green tea leaf
NPDI-GdcFMg Green Tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of MATE2-K by Green Tea In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • MATE2-K (SLC47A2)
metformin green tea leaf
NPDI-_Zkjzg Green Tea (Camellia sinensis) Inhibitory effects of various beverages on ritodrine sulfation by recombinant human sulfotransferase isoforms SULT1A1 and SULT1A3 Green tea inhibition of SULT1A3 using dopamine as the substrate In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • SULT1A3
dopamine dopamine sulfate green tea leaf
NPDI-lih1tg Green Tea (Camellia sinensis) Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects. OATP1A2 inhibition with green tea In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • OATP1A2 (SLCO1A2)
nadolol green tea leaf
NPDI-i6A3tw Green Tea (Camellia sinensis) Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects. Green tea interaction with nadolol In Vivo Interaction positive — PK Interaction - Increased systemic exposure
  • OATP1A2 (SLCO1A2)
nadolol green tea leaf
NPDI-cpRc8Q Green Tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of MATE1 by Green Tea In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • MATE1 (SLC47A1)
metformin green tea leaf
NPDI-4v_54A Green Tea (Camellia sinensis) Effects of repeated green tea catechin administration on human cytochrome P450 activity. In Vivo Interaction negative — No Effect (based on bioequivalence limits)
  • CYP1A2
caffeine green tea leaf
NPDI-H8eoWA Green Tea (Camellia sinensis) Effects of repeated green tea catechin administration on human cytochrome P450 activity. In Vivo Interaction negative — No Effect (based on bioequivalence limits)
  • CYP2C9
losartan green tea leaf
NPDI-wmFE6g Green Tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of OATP1B3 by Green Tea In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • OATP1B3 (SLCO1B3)
bromosulfophthalein green tea leaf
NPDI-KsBTjg Green Tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of OATP1B1 by Green Tea In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • OATP1B1 (SLCO1B1)
atorvastatin green tea leaf
NPDI-OBEe_w Green Tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of OATP1B3 by Green Tea In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • OATP1B3 (SLCO1B3)
atorvastatin green tea leaf
NPDI-8cPLyw Green Tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of OCT1 by Green Tea In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • OCT1 (SLC22A1)
metformin green tea leaf
NPDI-OQFZmw Green Tea (Camellia sinensis) Inhibitory effects of various beverages on ritodrine sulfation by recombinant human sulfotransferase isoforms SULT1A1 and SULT1A3 green tea inhibition of SULT1A1 using ritodrine as the substrate In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • SULT1A1
ritodrine ritodrine sulfate ester green tea leaf
NPDI-L5RmbA Green Tea (Camellia sinensis) Inhibitory effects of various beverages on ritodrine sulfation by recombinant human sulfotransferase isoforms SULT1A1 and SULT1A3 green tea inhibition of SULT1A3 using ritodrine as the substrate In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • SULT1A3
ritodrine ritodrine sulfate ester green tea leaf
NPDI-xsuAIg Green Tea (Camellia sinensis) Effects of repeated green tea catechin administration on human cytochrome P450 activity. In Vivo Interaction positive — PK Interaction - Increased systemic exposure
  • CYP3A4
buspirone green tea leaf