Inhibition of P-gp by Green Tea CSV JSON

In Vitro Transporter Inhibition Experiment

Inhibition of P-gp by Green Tea

Inhibition was detected.  Cutoff used — NA

digoxin 1326303

green tea leaf

  • P-gp (ABCB1)

Cell system Caco-2 cells

Results

In the presence of green tea, the B-A transport of digoxin significantly decreased from 3.2%/h to < 2.4%/h (P < 0.01 to 0.001). In the presence of green tea, the B-A transport was greater than the A-B transport.

Sample Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

Cell Culture Conditions

transwell plates

7

Viability and Function

> 200 Ω

Assay Conditions

4 h

37 deg C

5 µM

1-10% v/v

Prof. Toshiyuki Kan (Department of Synthetic Organic and Medicinal Chemistry, University of Shizuoka, Japan)

Control Experiment