metformin
InChIKey: XZWYZXLIPXDOLR-UHFFFAOYSA-N

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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-DGEDfw Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of MATE2-K by (-)-epigallocatechingallate In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • MATE2-K (SLC47A2)
 metformin (-)-epigallocatechin gallate
NPDI-n4yXtA Goldenseal (Hydrastis canadensis) R21 Goldenseal Project Intravenous Metformin/Oral Inhibitor Mouse Study - Goldenseal Extract In Vivo Interaction negative — No Effect (based on bioequivalence limits)
metformin aqueous goldenseal extract
NPDI-8cPLyw Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of OCT1 by Green Tea In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • OCT1 (SLC22A1)
 metformin green tea leaf
NPDI-dS7vAQ Goldenseal (Hydrastis canadensis) R21 Goldenseal Project Oral Metformin/Oral Inhibitor Mouse Study - Goldenseal Extract In Vivo Interaction positive — PK Interaction - Decreased systemic exposure
metformin aqueous goldenseal extract
NPDI-27Q7-A Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of OCT1 by (-)-epigallocatechin gallate In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • OCT1 (SLC22A1)
 metformin (-)-epigallocatechin gallate
NPDI-eejWAQ Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Metformin uptake in MATE1 cells In Vitro Transporter Kinetics (Control experiment) positive — In Vitro Transport
  • MATE1 (SLC47A1)
 metformin
NPDI-YlzfNg Goldenseal (Hydrastis canadensis) R21 Goldenseal Project Intravenous Metformin/Oral Inhibitor Mouse Study - Imatinib In Vivo Interaction negative — No Effect (based on bioequivalence limits)
metformin imatinib
NPDI-cpRc8Q Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of MATE1 by Green Tea In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • MATE1 (SLC47A1)
 metformin green tea leaf
NPDI-yehRxQ Goldenseal (Hydrastis canadensis) R21 Goldenseal Project Oral Metformin/Oral Inhibitor Mouse Study - (-)-β-hydrastine In Vivo Interaction negative — No Effect (based on bioequivalence limits)
metformin (-)-beta-hydrastine
NPDI-bVuJYQ Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of OCT2 by (-)-epigallocatechin gallate In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • OCT2 (SLC22A2)
 metformin (-)-epigallocatechin gallate
NPDI-b-Qyxw Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Metformin uptake in OCT2 cells In Vitro Transporter Kinetics (Control experiment) positive — In Vitro Transport
  • OCT2 (SLC22A2)
 metformin
NPDI-GaLUxw Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of MATE1 by (-)-epigallocatechingallate In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • MATE1 (SLC47A1)
 metformin (-)-epigallocatechin gallate
NPDI-yewsDg Goldenseal (Hydrastis canadensis) R21 Goldenseal Project Oral Metformin/Oral Inhibitor Mouse Study - Imatinib In Vivo Interaction positive — PK Interaction - Decreased systemic exposure
metformin imatinib
NPDI-KWj0Jg Goldenseal (Hydrastis canadensis) R21 Goldenseal Project Oral Metformin/Oral Inhibitor Mouse Study - Berberine In Vivo Interaction negative — No Effect (based on bioequivalence limits)
metformin berberine
NPDI-WsMb-g Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Metformin uptake in MATE2-K cells In Vitro Transporter Kinetics (Control experiment) positive — In Vitro Transport
  • MATE2-K (SLC47A2)
 metformin
NPDI-nm2fYg Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of OCT2 by Green Tea In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • OCT2 (SLC22A2)
 metformin green tea leaf
NPDI-_zSDOQ Goldenseal (Hydrastis canadensis) A clinical study of transporter-mediated goldenseal drug interactions clinical goldenseal - metformin study In Vivo Interaction positive — PK Interaction - Decreased systemic exposure
  • MATE1 (SLC47A1)
  • MATE2-K (SLC47A2)
  • OCT1 (SLC22A1)
  • OCT2 (SLC22A2)
 metformin goldenseal root extract
NPDI-GdcFMg Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of MATE2-K by Green Tea In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • MATE2-K (SLC47A2)
 metformin green tea leaf
NPDI-F3BK2A Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Metformin uptake in OCT1 cells In Vitro Transporter Kinetics (Control experiment) positive — In Vitro Transport
  • OCT1 (SLC22A1)
 metformin

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