Need public description.

  • Goldenseal (Hydrastis canadensis)

None listed

None listed

None listed

None listed
ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-Bi2fGw Goldenseal (Hydrastis canadensis) In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4 phenotypes CYP3A4 Experiment In Vivo Interaction positive — PK Interaction – Increased systemic exposure
  • CYP3A4
midazolam goldenseal root extract
NPDI-fDeLbA Goldenseal (Hydrastis canadensis) In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4 phenotypes CYP2D6 Experiment In Vivo Interaction positive — PK Interaction – Increased systemic exposure
  • CYP2D6
debrisoquine goldenseal root extract
NPDI-Vt7rHw Goldenseal (Hydrastis canadensis) In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4 phenotypes CYP2E1 Experiment In Vivo Interaction negative — No Effect (based on bioequivalence limits)
  • CYP2E1
chloroxazone goldenseal root extract
NPDI-Aw3yIw Goldenseal (Hydrastis canadensis) Supplementation With Goldenseal (Hydrastis canadensis), but not Kava Kava (Piper methysticum), Inhibits Human CYP3A Activity In Vivo CYP3A4 Experiment - MDZ probe In Vivo Interaction positive — PK Interaction – Increased systemic exposure
  • CYP3A4
midazolam goldenseal root extract
NPDI-0eAs4g Goldenseal (Hydrastis canadensis) Influence of Goldenseal Root on the Pharmacokinetics of Indinavir Indinavir/ Goldenseal Root Experiment In Vivo Interaction negative — No Effect (based on bioequivalence limits)
  • CYP3A4
indinavir goldenseal root extract
NPDI-T6Zq4Q Goldenseal (Hydrastis canadensis) In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4 phenotypes CYP1A2 Experiment In Vivo Interaction negative — No Effect (based on bioequivalence limits)
  • CYP1A2
caffeine goldenseal root extract
NPDI-hYXlNQ Goldenseal (Hydrastis canadensis) An ex vivo approach to botanical-drug interactions: A proof of concept study 3A4/5 Inhibition by Goldenseal In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
midazolam 1'-hydroxymidazolam goldenseal root extract
NPDI-OCQ06Q Goldenseal (Hydrastis canadensis) Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components 3A4 Inhibition by GS Extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone goldenseal root extract
NPDI-jjfDSA Goldenseal (Hydrastis canadensis) Effects of Herbal Products and their Constituents on Human Cytochrome P4502E1 Activity CYP2E1 Inhibition by GS root extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2E1
p-nitrophenol 4-nitrophenyl sulfate goldenseal root extract
NPDI--K80vw Goldenseal (Hydrastis canadensis) Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components 2C9 Inhibition by GS Extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac goldenseal root extract
NPDI-qzY27Q Goldenseal (Hydrastis canadensis) Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components 2D6 Inhibition by GS Extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
bufuralol 1'-hydroxybufuralol goldenseal root extract